Chemical proteomic identification of functional cysteines with atypical electrophile reactivities [0.03%]
具有非典型亲电反应活性的功能半胱氨酸的化学蛋白质组鉴定
Kevin Litwin,Vincent M Crowley,Radu M Suciu et al.
Kevin Litwin et al.
Cysteine-directed covalent ligands have emerged as a versatile category of chemical probes and drugs that leverage thiol nucleophilicity to form permanent adducts with proteins of interest. Understanding the scope of cysteines that can be t...
Synthesis of 8-oxo-dGTP and its β,γ-CH2-, β, γ-CHF-, and β, γ-CF2- analogues [0.03%]
8-氧代-dGTP及其β,γ-CH2-、β,γ-CHF-和β,γ-CF2-类似物的合成
Yiying Zheng,Pouya Haratipour,Boris A Kashemirov et al.
Yiying Zheng et al.
Three novel 8-oxo-dGTP bisphosphonate analogues of 3 in which the bridging β,γ-oxygen is replaced by a methylene, fluoromethylene or difluoromethylene group (4-6, respectively) have been synthesized from 8-oxo-dGMP 2 by reaction of its mo...
Chemoenzymatic route to stereodefined 2-(azidophenyl)oxazolines for click chemistry [0.03%]
用于点击化学的立体定义2-叠氮苯基恶唑啉的化学生物合成路线
Paige J Monsen,Frederick A Luzzio
Paige J Monsen
Aryl-substituted esters of a racemic diprotected 2-azido-1-alkanol were submitted to the Staudinger/aza-Wittig reaction in order to assess scope and establish conditions for their cyclization to the corresponding 2,4,5-trisubstituted oxazol...
Plakortinic acids C and D: a pair of peroxide-polyketides possessing a rare 7,8-dioxatricyclo[4.2.2.02,5]dec-9-ene core from a two-sponge association of Plakortis symbiotica-Xestospongia deweerdtae [0.03%]
来自共生海绵Plakortis symbiotica-Xestospongia deweerdtae的具有罕见7,8-二氧杂三环并[4.2.2.02,5]癸-9-烯核心的过氧化聚酮类化合物plakortinic酸C和D
Carlos Jiménez-Romero,Luis A Amador,Abimael D Rodríguez
Carlos Jiménez-Romero
Plakortinic acids C (3) and D (4), two unprecedented peroxide-polyketides with 7,8-dioxatricyclo[4.2.2.02,5]dec-9-ene scaffold, as well as known biogenetically related congeners, plakortinic acids A (1) and B (2), were isolated from a two-s...
Jinya Yin,Jon D Rainier
Jinya Yin
Described here is a one-pot method of synthesizing amidonaphthoquinones from the corresponding aminonaphthoquinones. The scope of amides that can be synthesized using this methodology is relatively broad and the yield of product is higher t...
Synthesis of amide derivatives for electron deficient amines and functionalized carboxylic acids using EDC and DMAP and a catalytic amount of HOBt as the coupling reagents [0.03%]
以EDC和DMAP以及少量的HOBt为偶联试剂合成电子效应缺电子胺及羧酸衍生物的研究
Arun K Ghosh,Dana Shahabi
Arun K Ghosh
A convenient protocol for amide bond formation for electron deficient amines and carboxylic acids is described. Amide coupling of aniline derivatives has been investigated with a number of reagents under a variety of reaction conditions. Th...
Synthesis and biological evaluation of an antibacterial azaborine retinoid isostere [0.03%]
一种抗菌的氮硼环视黄醇等价物的合成与生物评估
Brittney A Haney,Cassandra L Schrank,William M Wuest
Brittney A Haney
Our continued synthetic interest in this class of retinoids, CD437 and its analogs, against methicillin-resistant Staphylococcus aureus (MRSA) has brought us to explore further isosteric substitutions within the scaffold. Although our previ...
Paige J Monsen,Frederick A Luzzio
Paige J Monsen
An array of arylnitro compounds with various functionality were treated with freshly-prepared aluminum amalgam in THF/water solution and resulted in the corresponding arylamines. The Al(Hg)-mediated reductions are relatively rapid with cons...
Hein Vuong,Michael R Stentzel,Douglas A Klumpp
Hein Vuong
A series of vinylogous imines have been prepared from anilines and cinnamaldehydes. These substrates react in superacidic media to provide quinolines and related compounds. A mechanism for the conversion is proposed which involves the cycli...
Tryptoquivalines W and X, two new compounds from a Hawaiian fungal strain and their biological activities [0.03%]
来源于夏威夷真菌菌株的两个新的隐翅虫素类似物W和X及它们的生物活性
Kh Ahammad Uz Zaman,Zhenquan Hu,Xiaohua Wu et al.
Kh Ahammad Uz Zaman et al.
Two new compounds tryptoquivalines W (1) and X (2) were isolated from a Hawaiian soil fungal strain Aspergillus terreus FS107. The soil sample was collected on the top of Mauna Kea, the tallest mountain in Hawaii. The structures of compound...