Mara K O&#x;Neill,Brent F Piligian,Claire D Olson et al.
Mara K O&#x;Neill et al.
Trehalose is a non-reducing sugar whose ability to stabilize biomolecules has brought about its widespread use in biological preservation applications. Trehalose is also an essential metabolite in a number of pathogens, most significantly t...
Stereocontrolled 1- S-glycosylation and comparative binding studies of photoprobe-thiosaccharide conjugates with their O-linked analogs [0.03%]
立体选择性S-糖基化及光探针硫醇糖与相应氧连接类似物的配体结合比较研究
Lingquan Deng,Xin Wang,Suji Uppalapati et al.
Lingquan Deng et al.
The use of thioglycosides and other glycan derivatives with anomeric sulfur linkages is gaining increasing interest, both in synthesis and in various biological contexts. Herein, we demonstrate the occurrence and circumvention of anomerizat...
David G I Kingston,Lawrence Tamarkin,Giulio F Paciotti
David G I Kingston
Paclitaxel (Taxol®) is one of the most important anticancer agents developed over the last 30 years. Its primary mechanism of action is by interaction with the cellular protein tubulin, causing irreversible polymerization to microtubules. ...
Jason C Green,G Leslie Burnett th,Thomas R R Pettus
Jason C Green
Two cycloaddition strategies are described that lead to various chroman spiroketals from assorted exocyclic enol ethers. Unlike conventional thermodynamic ketalization strategies, the stereochemical outcome for this approach is determined b...
3-Acyloxy-1,4-enyne: a New Five-carbon Synthon for Rhodium-Catalyzed (5+2) Cycloadditions [0.03%]
3-酰氧基-1,4-烯炔：铑催化(5+2)环加成反应的新五碳合成子
Casi M Schienebeck,Xiaoxun Li,Xing-Zhong Shu et al.
Casi M Schienebeck et al.
Seven-membered rings are ubiquitous in natural products and pharmaceutical agents and their syntheses continue to stimulate the development of novel synthetic methods. The (5+2) cycloaddition is one of the most efficient ways to access seve...
New ligand platforms featuring boron-rich clusters as organomimetic substituents [0.03%]
含有富硼基团的配体平台作为有机模拟取代基
Alexander M Spokoyny
Alexander M Spokoyny
200 years of research with carbon-rich molecules have shaped the development of modern chemistry. Research pertaining to the chemistry of boron-rich species has historically trailed behind its more distinguished neighbor (carbon) in the per...
Chemical composition-oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein [0.03%]
化学组成决定的L5受体选择性(L5是一种天然促动脉粥样硬化低密度脂蛋白)
Liang-Yin Ke,David A Engler,Jonathan Lu et al.
Liang-Yin Ke et al.
Anion-exchange chromatography resolves human plasma low-density lipoprotein (LDL) into 5 subfractions, with increasing negative surface charge in the direction of L1 to L5. Unlike the harmless L1 to L4, the exclusively atherogenic L5 is rej...
Anti-proliferative withanolides from the Solanaceae: a structure-activity study [0.03%]
一种茄科抗增殖_withanolide的结构活性研究
Huaping Zhang,Abbas K Samadi,Mark S Cohen et al.
Huaping Zhang et al.
As part of our search for bioactive compounds from plant biodiversity, 29 withanolides (1, 3-6, 9, 12-18, and 20-35) were recently isolated from three members of the Solanaceae: Physalis longifolia, Vassobia breviflora, and Withania somnife...
John P Richard
John P Richard
Deprotonation of carbon and decarboxylation at enzyme active sites proceed through the same carbanion intermediates as for the uncatalyzed reactions in water. The mechanism for the enzymatic reactions can be studied at the same level of det...
Martha Sibrian-Vazquez,Jorge O Escobedo,Mark Lowry et al.
Martha Sibrian-Vazquez et al.
Red-shifted and near-infrared (NIR)-active rhodamine analogs and their boronic acid derivatives were synthesized and studied. These latter compounds function as fluorogenic NIR active substrates for sugar sensing. The effects of benzannulat...