Chemical composition-oriented receptor selectivity of L5, a naturally occurring atherogenic low-density lipoprotein [0.03%]
化学组成决定的L5受体选择性(L5是一种天然促动脉粥样硬化低密度脂蛋白)
Liang-Yin Ke,David A Engler,Jonathan Lu et al.
Liang-Yin Ke et al.
Anion-exchange chromatography resolves human plasma low-density lipoprotein (LDL) into 5 subfractions, with increasing negative surface charge in the direction of L1 to L5. Unlike the harmless L1 to L4, the exclusively atherogenic L5 is rej...
Anti-proliferative withanolides from the Solanaceae: a structure-activity study [0.03%]
一种茄科抗增殖_withanolide的结构活性研究
Huaping Zhang,Abbas K Samadi,Mark S Cohen et al.
Huaping Zhang et al.
As part of our search for bioactive compounds from plant biodiversity, 29 withanolides (1, 3-6, 9, 12-18, and 20-35) were recently isolated from three members of the Solanaceae: Physalis longifolia, Vassobia breviflora, and Withania somnife...
John P Richard
John P Richard
Deprotonation of carbon and decarboxylation at enzyme active sites proceed through the same carbanion intermediates as for the uncatalyzed reactions in water. The mechanism for the enzymatic reactions can be studied at the same level of det...
Martha Sibrian-Vazquez,Jorge O Escobedo,Mark Lowry et al.
Martha Sibrian-Vazquez et al.
Red-shifted and near-infrared (NIR)-active rhodamine analogs and their boronic acid derivatives were synthesized and studied. These latter compounds function as fluorogenic NIR active substrates for sugar sensing. The effects of benzannulat...
Joseph Moran,Michael J Krische
Joseph Moran
Ruthenium-catalyzed transfer hydrogenation of diverse π-unsaturated reactants in the presence of aldehydes provides products of carbonyl addition. Dehydrogenation of primary alcohols in the presence of the same π-unsaturated reactants pro...
First total synthesis of the (±)-2-methoxy-6-heptadecynoic acid and related 2-methoxylated analogs as effective inhibitors of the leishmania topoisomerase IB enzyme [0.03%]
(±)-2-甲氧基-6-十七炔酸和相关2-甲氧基化类似物作为有效抑制利什曼原生动物拓扑异构酶IB的首例全合成化合物
Néstor M Carballeira,Michelle Cartagena,Fengyu Li et al.
Néstor M Carballeira et al.
The fatty acids (±)-2-methoxy-6Z-heptadecenoic acid (1), (±)-2-methoxy-6-heptadecynoic acid (2) and (±)-2-methoxyheptadecanoic acid (3) were synthesized and their inhibitory activity against the Leishmania DNA topoisomerase IB enzyme (Ld...
Synthesis of Lipid A and Inner Core LPS ligands containing 4-amino-4-deoxy-l-arabinose units [0.03%]
含4-氨基-4-脱氧-L-阿拉伯糖单位的脂质A和内核LPS配体合成
Alla Zamyatina,Ralph Hollaus,Markus Blaukopf et al.
Alla Zamyatina et al.
Attachment of 4-amino-4-deoxy-l-arabinose to phosphates or sugar hydroxyl groups of lipopolysaccharide contributes to bacterial resistance against common antibiotics. For a detailed study of antigenic properties and binding interactions, Ar...
Balancing life with glycoconjugates: monitoring unfolded protein response-mediated anti-angiogenic action of tunicamycin by Raman Spectroscopy [0.03%]
糖复合物与生命平衡：利用拉曼光谱技术监测硫酸粘多糖的未折叠蛋白反应介导的抗血管生成作用
Maria O Longas,Ashok Kotapati,Kilari Pvrk Prasad et al.
Maria O Longas et al.
Asparagine-linked protein glycosylation is a hallmark for glycoprotein structure and function. Its impairment by tunicamycin [a competitive inhibitor of N-acetylglucosaminyl 1-phosphate transferase (GPT)] has been known to inhibit neo-vascu...
Design, synthesis, and characterization of novel nanowire structures for photovoltaics and intracellular probes [0.03%]
新型纳米线结构的设计、合成与表征用于光伏和胞内探测器
Bozhi Tian,Charles M Lieber
Bozhi Tian
Semiconductor nanowires (NWs) represent a unique system for exploring phenomena at the nanoscale and are expected to play a critical role in future electronic, optoelectronic, and miniaturized biomedical devices. Modulation of the compositi...
Brian P Jackson,Vivien F Taylor,Tracy Punshon et al.
Brian P Jackson et al.
Arsenic exposure to humans is pervasive, and, increasingly, studies are revealing adverse health effects at ever lower doses. Drinking water is the main route of exposure for many individuals; however, food can be a significant source of ar...