Spray freeze dried niclosamide nanocrystals embedded dry powder for high dose pulmonary delivery [0.03%]
用于高剂量肺递送的喷雾冷冻干燥的硝硫氰络合物纳米晶嵌入干粉
Shengyu Zhang,Shen Yan,Kangwei Lu et al.
Shengyu Zhang et al.
Based on the drug repositioning strategy, niclosamide (NCL) has shown potential applications for treating COVID-19. However, the development of new formulations for effective NCL delivery is still challenging. Herein, NCL-embedded dry powde...
A CFD-DEM investigation of powder transport and aerosolization in ELLIPTA® dry powder inhaler [0.03%]
使用CFD-DEM方法研究埃利塔®干粉吸入器中的粉末传输和气溶胶化过程
Mostafa Sulaiman,Xiaoyu Liu,Sankaran Sundaresan
Mostafa Sulaiman
We have performed Computational Fluid Dynamics-Discrete Element Method (CFD-DEM) simulations of air and particles in a commercial ELLIPTA® inhaler. We simulated the fluidization, deagglomeration and transport of carrier and API particles, ...
Automatic 3D cluster modelling of COVID-19 through voxel-based redistribution [0.03%]
基于体素重新分配的自动三维集群建模在COVID-19中的应用
Mingzhi Wang,Yushi Liu,Beimeng Qi et al.
Mingzhi Wang et al.
Computational analysis of virus dynamics provides a non-contact environment for the study of the vital object. Cluster modelling is an essential step to investigate the properties of a group of viruses, and an automatic approach is required...
Targeted delivery of inhalable drug particles in a patient-specific tracheobronchial tree with moderate COVID-19: A numerical study [0.03%]
针对中度新冠肺炎患者的个体化气管支气管树可吸入药粒子的靶向输送：数值研究
Jianwei Wang,Ya Zhang,Xiaole Chen et al.
Jianwei Wang et al.
The coronavirus disease 2019 (COVID-19) pandemic has led to severe social and economic disruption worldwide. Although currently no consent has been reached on a specific therapy that can treat COVID-19 effectively, several inhalation therap...
Erratum to "Fragmentation dynamics of single agglomerate-to-wall impaction" [Powder Technology 378 (2021) 561-575, DOI: 10.1016/j.powtec.2020.10.021] [0.03%]
“单个聚集体撞击壁面的破碎动力学”[Powder Technology，378（2021）561-575，DOI：10.1016/j.powtec.2020.10.021]一文勘误
A Lowe,G Singh,H-K Chan et al.
A Lowe et al.
[This corrects the article PMC8724865.].
Published Erratum
Powder technology. 2021 Jan 10:382:262. DOI:10.1016/j.powtec.2020.12.048 2021
A Lowe,G Singh,H-K Chan et al.
A Lowe et al.
The de-agglomeration characteristics of single agglomerate-wall impaction are examined using high-resolution shadowgraph imaging. Experiments are performed to investigate the effects of constituent particle size (D 50 from 3-7 μ m) and air...
Atomic Force Microscopy to Identify Dehydration Temperatures for Small Volumes of Active Pharmaceutical Ingredients [0.03%]
利用原子力显微镜鉴别活性药物成分小体积脱水温度的方法
Katherine Atamanuk,Myles C Thomas,Robert C Wadams et al.
Katherine Atamanuk et al.
The environmental conditions associated with changing the hydration state of active pharmaceutical ingredients (API) are crucial to understanding their stability, bioperformance, and manufacturability. Identifying the dehydration event usin...
Prahit Dubey,Urmila Ghia,Leonid A Turkevich
Prahit Dubey
Dustiness quantifies the propensity of a finely divided solid to be aerosolized by a prescribed mechanical stimulus. Dustiness is relevant wherever powders are mixed, transferred or handled, and is important in the control of hazardous expo...
M Rehula,R Adamek,V Spacek
M Rehula
It is possible to assess viscoelastic properties of materials by means of the stress relaxation test. This method records the decrease in pressing power in a tablet at its constant height. The cited method was used to evaluate the time-depe...
The effect of operating conditions on resistance parameters of filter media and limestone dust cake for uniformly loaded needle felts in a pilot scale test facility at ambient conditions [0.03%]
操作条件对中试规模试验设施均布加载针刺毡滤料及石灰粉尘饼阻力参数的影响
Mahmood Saleem,Gernot Krammer,M Suleman Tahir
Mahmood Saleem
Resistance parameters are essential for the prediction of pressure drop in bag filters. The reported values for limestone dust differ in magnitude and also depend on operating parameters. In this work, experimental data is provided from a p...