Historia Instytutu Chemii Bioorganicznej Polskiej Akademii Nauk w Poznaniu [0.03%]
波兰科学院波兹南生物有机化学研究所的历史
Luiza Handschuh,Marek Figlerowicz,Agnieszka Konrad et al.
Luiza Handschuh et al.
David B Mark Welch,Travis J Gould,Ada L Olins et al.
David B Mark Welch et al.
Human myeloid leukemia cells (HL-60/S4) exposed to hyperosmotic stress with sucrose undergo dehydration and cell shrinkage. Interphase chromatin and mitotic chromosomes congeal, exhibiting altered phase separation (demixing) of chromatin pr...
From single DNA adducts measurement to DNA adductomics in molecular epidemiology of cancer [0.03%]
从单个DNA加合物测量到癌症分子流行病学中的DNA加合体组学
Wanda Baer-Dubowska,Hanna Szaefer
Wanda Baer-Dubowska
Environmental carcinogens exert their carcinogenic effects by forming DNA adducts. This type of DNA damage can also be formed endogenously as a result of, e.g., oxidative damage. Unrepaired DNA adducts may induce mutations in critical genes...
The role of physicochemical processes in the formation of the 3D genome and compartmentalization of the cell nucleus [0.03%]
物理化学过程在三维基因组形成和细胞核区室化中的作用
Sergey V Razin
Sergey V Razin
The review analyzes the role of physicochemical processes in the formation of the function-dependent architecture of the cell nucleus, built on the platform of a folded genome. The main attention is paid to various forms of the phase separa...
MicroRNA-mediated gene regulation and the resilience of multicellular animals [0.03%]
微小核糖核酸介导的基因调控与多细胞动物的恢复力
Victor Ambros
Victor Ambros
MicroRNAs are small RNAs that enable parts of the genome to regulate the other parts of the genome by RNA::RNA complementarity. Genes that encode microRNAs function as trans-acting regulators of hundreds of other genes, primarily by inhibit...
Gliwice Scientific Meetings as a forum for discussion of research projects.Personal impressions [0.03%]
格利维策科研会议——讨论研究项目的论坛——个人感言
Krzysztof Szyfter
Krzysztof Szyfter
The article has been written for the occasion of 25 Anniversary of Gliwice Scientific Meetings (GSN). For this reason, I am going to present scientific contacts of the Institute of Oncology at Gliwice with the Institute of Human Genetics of...
Marek Rusin
Marek Rusin
The p53 tumor suppressor protein is best known as an activator of cell cycle arrest and apoptosis. Only a fraction of p53-activated genes encode proteins affecting cellular replication and various forms of cell death (apoptosis, ferroptosis...
Jekaterina Erenpreisa,Kristine Salmina,Ninel M Vainshelbaum et al.
Jekaterina Erenpreisa et al.
The early stress response by AP-1 (FOS/JUN), supported by upregulation of c-Myc and involved in cell-fate changes and adaptation to hostile environments, is increased in cancer. The review shows the biphasic character of this response with ...
Elisabetta Scarfiello,Julian Eichlinger,Gunter Meister
Elisabetta Scarfiello
MicroRNAs (miRNAs) are generated from stem-loop-structured double-stranded RNA precursors by the consecutive action of the two RNase III-type endoribonuclease Drosha and Dicer. However, such structures are very common on cellular transcript...
An engineering perspective on transcription, translation and their regulation [0.03%]
从工程学角度看转录、翻译及其调控
Jarosław Śmieja
Jarosław Śmieja
Information coded in DNA is replicated, modified and transmitted from the origins of protein-based life. Analogies of these processes to information processing, transmission and storage in computer systems is straightforward and can be util...