[Can the laws of physics be circumvented? On methods of super-resolution fluorescence microscopy] [0.03%]
［突破物理学限制的方法——超分辨荧光显微镜技术综述］
Adrian Rüfli
Adrian Rüfli
Biological sciences are increasingly uncovering the foundations of life in greater detail, made possible by the development of research methods enabling exploration at the nanometer scale. Optical microscopy, a field with a significant cont...
[Advances in the development of synthetic biology tools for the bioproduction of natural product analogues] [0.03%]
合成生物学工具的发展促进天然产物类似物生物制造综述
Piotr Michałowski,Aleksandra Bigos,Dorota Jakubczyk
Piotr Michałowski
Chemical compounds of natural origin, the so-called natural products and their derivatives, constitute the basis of medicines. They are widely used, among others, in the agricultural, veterinary, food and cosmetics industries. The article p...
[Sequencing the transcriptome of single cells: a path to discovering cellular biodiversity] [0.03%]
单细胞转录组测序：发现细胞类群多样性的途径
Anna Samelak-Czajka,Małgorzata Marszałek-Zeńczak,Paulina Jackowiak
Anna Samelak-Czajka
Single-cell transcriptomics (scRNA-Seq) is a breakthrough technology that has opened the way to characterizing gene expression with unprecedented resolution. It has enabled the discovery of the cellular diversity of organisms and tracing th...
Daniel Fochtman,Anna Wojakowska,Łukasz Marczak
Daniel Fochtman
Mass spectrometry (MS) as an analytical technique enables the identification and quantitative determination of proteins, metabolites, or lipids in a studied sample. However, this method has limitations regarding the number of molecules that...
Wojciech Witek,Wiktoria Ragin,Ha Linh Tran et al.
Wojciech Witek et al.
Structural biology is focused on understanding the architecture of biomolecules, such as proteins and nucleic acids. Deciphering the structure helps to understand their function in the cell at a very precise – molecular level. This makes i...
[Data-driven mass spectrometry methods (DDA) and data-independent methods (DIA) used in the analysis of biological material] [0.03%]
用于生物样品分析的数据驱动质谱方法（DDA）和数据非依赖性方法（DIA）
Marta Nolka-Szaszner,Aleksander Strugała,Łukasz Marczak
Marta Nolka-Szaszner
Mass spectrometry is an important tool in proteomic, metabolomic and lipidomic analysis. To fully use its potential, it is crucial to select and configure the appropriate analytical approach. For untargeted research, there are two main stra...
[From Sanger to genome sequencing - an overview of DNA sequencing technologies] [0.03%]
从桑格到基因组测序技术的回顾
Małgorzata Marcinkowska-Swojak,Magdalena Rakoczy,Jan Podkowiński et al.
Małgorzata Marcinkowska-Swojak et al.
There is no technique that would make a greater contribution to the development of genetics, molecular biology and medicine than DNA sequencing. For many years, the method based on enzymatic DNA synthesis developed by Frederic Sanger was th...
[Chemical simulations of quantum systems using quantum computers - review of algorithms and their experimental verification] [0.03%]
[使用量子计算机对量子系统进行化学模拟-算法及其实验验证的综述]
Konrad Wojciechowski,Krzysztof Kurowski,Cezary Mazurek
Konrad Wojciechowski
Computer simulations using ever-increasing computing power and machine learning techniques allow advanced molecular modelling, molecular dynamics simulations and studies of intermolecular interactions. However, due to the complexity of biol...
[Multi-analyte responsive luminescent probes for the detection of biochemical targets in cell models] [0.03%]
用于细胞模型中生物化学目标检测的多分析物发光探针
Anna Wychowaniec,Francesca Canyelles I Font,Masroor Ahmed Khan et al.
Anna Wychowaniec et al.
Luminescence has found wide application in biology, biotechnology and medicine. Particularly, fluorescent and bioluminescent probes allow visualization of molecular targets at the cellular level and even macromolecules or single small-molec...
Joanna Śliwiak,Anna Urbanowicz
Joanna Śliwiak
Enzymes, as biocatalysts, are an important target of many therapies and are also of great industrial importance, which is why repeatable and accurate parameterization of enzymatic catalysis is very important. The most popular spectrophotome...