[Pharmacological chaperone therapy for the treatment of inborn errors of metabolism] [0.03%]
[药理学伴侣治疗先天性代谢错误的方法]
Patryk Lipiński,Aleksandra Jezela-Stanek,Anna Tylki-Szymańska
Patryk Lipiński
The article describes the mechanism of molecular and pharmacological chaperones in the treatment of inborn errors of metabolism. The literature review of the usage of ambroxol acting as a pharmacological chaperone for beta-glucocerebrosidas...
[CRISPR/Cas as the intelligent immune system of bacteria and archea] [0.03%]
[CRISPR/Cas作为细菌和古菌的智能免疫系统]
Dalia Blicharska,Izabela Szućko-Kociuba,Ewa Filip et al.
Dalia Blicharska et al.
The invention of CRISPR is considered to be one of the most breakthrough discoveries in recent years in the history of biology, biotechnology, medicine, as well as the pharmaceutical and agricultural industries. The methods developed using ...
[Parental ageing and Assisted Reproduction Technologies: analysis of risk of chronic diseases in the progeny] [0.03%]
父母年龄与辅助生殖技术：后代慢性病风险的分析
Maria Florencia Heber,Hafsa Gulzar,Richard Musson et al.
Maria Florencia Heber et al.
Conception of a child at advanced parental age (> 35 years) has been steadily increasing in recent decades, especially in developed countries. Socio-economic factors, effective contraceptives, and the availability of Assisted Reproduction T...
[Molecular mechanism of progesterone action in the female reproductive system] [0.03%]
[孕酮在女性生殖系统中的作用机制]
Karolina Dobrzyń,Magdalena K Kowalik
Karolina Dobrzyń
Progesterone (P4) is a steroid hormone which participate in many processes in the female reproductive system. The hormone is produced mainly by the corpus luteum (CL), however, also the ovarian follicles, uterine tissues and placenta are ab...
Małgorzata Rydzy,Michał Tracz,Piotr Kolesiński et al.
Małgorzata Rydzy et al.
Rubisco is an enzyme found in photosynthetic organisms, which catalyse the first step of biomass accumulation: the carbon dioxide incorporation to ribulose-1,5-bisphosphate. Because of Rubisco’s complicated, multimeric structure and a pres...
[GPR18 receptor – the structure and the role in the physiology and pathophysiology] [0.03%]
[受体GPR18的结构及其在生理和病理中的作用]
Michalina Jurkiewicz,Greta Steć,Adrian Szczepaniak et al.
Michalina Jurkiewicz et al.
G-protein coupled receptors constitute the largest family of membrane receptors and they participate in the maintenance of the homeostasis in the body. Some of these receptors still remain orphan receptors as there is insufficient research ...
Natalia Gumińska,Rafał Milanowski
Natalia Gumińska
In eukaryotic cells, DNA occurs mainly in a linear chromosomes. In addition, it can also take the form of circular molecules. Mitochondrial and chloroplast genomes are the most thoroughly studied circular DNAs. However, the repertoire of ci...
Eliza Filipiak,Justyna Gołębiewska
Eliza Filipiak
Nucleoside boranephosphonates are nucleotide analogues in which one of the non-bridging oxygen atom of the phosphate part has been replaced by a borane group (-BH3). This modification imparts a wide spectrum of biological activity, e.g., ac...
Joanna Banasiak
Joanna Banasiak
Unlike vertebrates, plants lack specialized mobile immune cells and antibodies. However, it doesn’t mean that plants are not able to effectively defend themselves against pathogens. In the case of plants, almost every cell appears to be ab...
[Molecular mechanisms of Duchenne muscular dystrophy and new therapeutic strategies] [0.03%]
[Duchenne肌营养不良的分子机理及新的治疗策略]
Paulina Podkalicka,Małgorzata Myszka,Józef Dulak et al.
Paulina Podkalicka et al.
Duchenne muscular dystrophy (DMD) is an X-linked genetic disease affecting approximately 1 in 5,000 born boys. It is caused by mutations in the DMD gene encoding dystrophin, which protects muscle fibers upon contraction. Its absence leads t...