Bożena Gabryel
Bożena Gabryel
Synthetic cathinones are the group of the most frequently identified so-called new psychoactive substances with a strong stimulating effect and high addictive potential. It is now believed that the use of these compounds increases the risk ...
Dalia Blicharska,Izabela Szućko-Kociuba,Ewa Filip et al.
Dalia Blicharska et al.
The Prime Editing method introduces the expected manipulations within a given genome with a Cas9-nicase and pegRNA structure and a reverse transcriptase, which is responsible for the synthesis of the segment, which is then incorporated into...
[The infinite potential of a single substance: The history of tamoxifen as an example of drug repositioning] [0.03%]
一物多用的无限可能——以托美司汀为例看老药新用的发展历程
Kalina Spławska,Tomasz Wilanowski
Kalina Spławska
Known for a long time, well-tested substances are still finding new applications in science, medicine and industry. This is a popular and cost-effective strategy because, when searching for new applications, effective methods of their large...
Jan Wnuk,Tomasz Wilanowski
Jan Wnuk
Malignant melanoma is a dangerous skin cancer, accounting for the majority of skin cancer-related deaths. Many patients with this cancer have the V600E mutation in the BRAF gene. This mutation causes constitutive activation of the MAPK/ERK ...
[The use of L-phenylalanine ammonia lyase inhibitors in plant ecophysiological studies] [0.03%]
[L-苯丙氨酶抑制剂在植物生态生理学研究中的应用]
Karolina Urban,Tomasz Hura
Karolina Urban
Phenylalanine ammonia lyase (PAL) is a key enzyme controlling the biosynthesis of phenolic compounds in plants. PAL catalyzes ammonia elimination from L-phenylalanine in a reaction that yields cinnamic acid, a precursor of a large group of ...
[Neuroprotective effect of curcumin and its potential use in the treatment of neurodegenerative diseases] [0.03%]
姜黄素的神经保护作用及其在神经退行性疾病治疗中的潜在应用价值
Mikołaj Górka,Natalia Białoń,Dominika Bieczek et al.
Mikołaj Górka et al.
The development of methods used in molecular biology has allowed a milestone in medical and pharmaceutical sciences. Progress has also been made in the field of pharmacognosy, which places substances of natural origin contained in plant raw...
[Everything on the right place – the role of VPS10P receptors in intracellular protein sorting] [0.03%]
[各就各位—VPS10P受体在细胞内蛋白质分选中的作用]
Paulina Kamińska,Sylwia Piątek,Magdalena Bieniek et al.
Paulina Kamińska et al.
VPS10P (vacuolar protein sorting 10 protein) domain receptors consitute a family of sorting receptors which are responsible for directing their protein cargo into destined subcellular localization. Functions of VPS10P domain receptors have ...
Martyna Pietrzak,Agnieszka Pękala-Safińska
Martyna Pietrzak
[The biological role of neuronostatin, a hormone encoded by the somatostatin gene] [0.03%]
神经源素的生物学作用——一种由生长抑素基因编码的激素
Małgorzata Krążek,Adrian Ligęza,Tatiana Wojciechowicz et al.
Małgorzata Krążek et al.
Neuronostatin is a peptide hormone encoded by the somatostatin gene. Neuronostatin was discovered in 2008 using bioinformatics methods. Studies in rodents have shown that it exerts a widespread effects in the central nervous system, as well...
[Multiparametric analysis of proteolytic enzyme activity using mass cytometry] [0.03%]
基于质谱流式细胞术的蛋白酶活性多参数分析方法研究
Katarzyna Małgorzata Groborz
Katarzyna Małgorzata Groborz