Metformin and the molecular pathways of aging: Searching for the modern elixir of life [0.03%]
二甲双胍与衰老的分子通路：寻找现代长生不老药
B Teofilović,S Mirić,S Maleškić Kapo et al.
B Teofilović et al.
Metformin, a well-established antidiabetic drug, has recently gained attention in geroscience for its potential to modulate key aging-related pathways. This review aims to summarize current knowledge regarding metformin's mechanisms of acti...
Impact of famotidine on blood carnitine levels and L-carnitine supplementation dose in tube-fed patients with severe motor and intellectual disabilities [0.03%]
法莫替丁对管饲喂养的重度运动和智力障碍患者的血清肉毒碱水平及左旋肉碱补充剂量的影响
N Sato,M Arakawa,Y Urakawa et al.
N Sato et al.
Introduction: Carnitine is essential for mitochondrial fatty acid transport and energy production. Tube-fed patients with severe motor and intellectual disabilities (SMID) receiving carnitine-free enteral nutrition are at increased risk of ...
Observational Study
Die Pharmazie. 2025 Oct 1;80(9):88-92. DOI:10.1691/ph.2025.5570 2025
Effectiveness of polypharmacy measures consisting of a pharmacist check followed by a multidisciplinary team review in patients with poly-pharmacy admitted to a neurology ward [0.03%]
药剂师检查联合多学科团队复查干预措施对神经内科住院老年患者的疗效研究
S Yamada,S Nishida,Y Hayashi et al.
S Yamada et al.
Patients with neurological disease are at high risk of polypharmacy. We previously reported that a countermeasure against polypharmacy which combined a pharmacist check followed by a multidisciplinary team review was useful for diabetes pat...
Observational Study
Die Pharmazie. 2025 Oct 1;80(9):102-107. DOI:10.1692/ph.2025.5555 2025
Prediction of cabazitaxel-induced severe neutropenia based on dose-to-albumin ratio and evaluation of clinical utility [0.03%]
基于剂量与白蛋白比值预测卡巴他赛所致严重中性粒细胞减少症及临床评估其作用价值
A Kageyama,Y Nakazawa,D Harada et al.
A Kageyama et al.
Cabazitaxel is a highly protein-bound drug that has been associated with the development of severe neutropenia, and decreased albumin (Alb) levels may contribute to this phenomenon. For some highly protein-bound drugs, adjustment of drug co...
Temporal effects of empirical round-up of serum creatinine on the accuracy of estimated kidney function after critical illness [0.03%]
重症监护后血清肌酐实测值对估计肾功能准确性的时效影响
R Mikami,S Imai,M Hayakawa et al.
R Mikami et al.
This study aimed to evaluate the temporal effect of a serum creatinine (SCr) correction intervention in critically ill patients with daily muscle wasting. A total of 5,355 critical care days in 574 patients with creatinine clearance (Clcr) ...
Formulation development and optimization of artemether-lumefantrine self-nanoemulsifying drug delivery systems [0.03%]
青蒿琥酯-卢抗氨酚自纳米乳化给药体系的研制及优化
T R Mudyahoto,O A Omoteso,S M Khamanga et al.
T R Mudyahoto et al.
Poor aqueous solubility may decrease the absorption and oral bioavailability of lipophilic drugs. In the current study, artemether (ART) and lumefantrine (LMF) o/w self-nano emulsifying drug delivery system (SNEDDS) formulations were prepar...
Glycyrrhizic acid inhibited inflammatory response in LPS-stimulated microglial BV2 cells via MAPK, Akt and NF-κB signaling pathways [0.03%]
甘草酸通过MAPK、Akt和NF-κB信号通路抑制LPS刺激的小胶质细胞BV2的炎症反应
Binfeng Cheng,Yuqian Dong,Xiaolu Li et al.
Binfeng Cheng et al.
Activation of microglia plays a pivotal role in the pathogenesis of neuroinflammation-mediated neurodegenerative diseases. Glycyrrhizic acid (GA), a principal triterpenoid saponin in Glycyrrhiza glabra, has been reported to exhibit a range ...
Cinchona bark and quinine as psychiatric treatments in Portugal, 1700-1900 [0.03%]
18至20世纪奎宁和金鸡纳皮在葡萄牙的精神病治疗中扮演的角色
M G Semedo,A L Pereira,J R Pita
M G Semedo
Cinchona bark and its main medicinal derivative - quinine - are known antimalarials. Until the 20th century, medicines with Cinchona bark or quinine were the only effective treatment for malaria used on a large-scale. However, Cinchona bark...
Effects of blood and brain midazolam concentrations on prolonged sedation in rats with low albumin levels [0.03%]
血清白蛋白低下大鼠の長期鎮静化において血液中・脳中のミダゾラム濃度が及ぼす影響
T Yano,S Watanabe,G Kato et al.
T Yano et al.
Midazolam is a short-acting benzodiazepine widely used for sedation; however, its duration of action can be prolonged by various factors including hypoalbuminemia. Previous behavioral studies in rats with low albumin levels reported reduced...