Research progress on the role of DDR1 in cancer and targeted therapy strategy [0.03%]
DDR1在癌症中的研究进展及其靶向治疗策略
Xiaoying Guan,Yajie Zhang,Xiaoli Guan et al.
Xiaoying Guan et al.
Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagen. Abnormal activation of DDR1 is closely related to the occurrence and development of solid tumors and plays an important role in the reg...
Cell surface topography differs in the human "glia-like" and glioma cultures [0.03%]
人源"星形胶质细胞样"和glioma培养系的细胞表面形态不同
Ivana Sivakova,Maria Lorencova,Anna Perzelova et al.
Ivana Sivakova et al.
Glioblastoma multiforme is the most malignant and incurable primary brain tumor. Infiltrative growth of gliomas into surrounding brain tissue may cause the presence of normal cells in glioma cultures. The aim of this study is to develop a s...
SLC44A1 promotes AML progression and chemoresistance by regulating the Notch signaling pathway [0.03%]
SLC44A1通过调节Notch信号通路促进急性髓系白血病进展和耐药性
Shuyun Cao,Chengyun Pan,Xiuying Hu et al.
Shuyun Cao et al.
Despite advances in treatment, acute myeloid leukemia (AML) remains a formidable therapeutic challenge, highlighting the urgent need for novel biomarkers and therapeutic targets. The choline transporter SLC44A1 has been implicated in cancer...
Prognostic value and clinical significance of tumoral PD-L1 and stromal α-SMA expression in diffuse pleural mesothelioma [0.03%]
肿瘤PD-L1和间质α-SMA表达在弥漫性胸膜间皮瘤的预后价值及临床意义
Yeqi Sun,Lan Li,Lei Cai et al.
Yeqi Sun et al.
Diffuse pleural mesothelioma (PM) is a rare malignant neoplasm with an extremely poor prognosis. Prognostic assessment remains challenging, highlighting the urgent need for reliable biomarkers to guide precise and effective therapy. Program...
DNA methylation-predicted GDF-15 and mortality in cancer survivors: a cohort study [0.03%]
基于DNA甲基化预测的GDF-15与癌症幸存者的死亡率的关系：一项队列研究
Jingying Nong,Kejian Shi,Yi Zhang
Jingying Nong
Developing non-invasive prognostic biomarkers remains critical to improving personalized cancer care. Growth differentiation factor-15 (GDF-15), a TGF-β family cytokine, plays a key role in tumorigenesis and immune evasion. Circulating GDF...
Treatment-Related Toxicity of the BEAM/BeEAM Conditioning Regimen in Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation [0.03%]
BEAM/BeEAM预处理方案在自体造血干细胞移植患者中的毒副作用
Barbora Kašperová,Michal Mego,Soňa Čierniková et al.
Barbora Kašperová et al.
Conditioning regimens prior to hematopoietic stem cell transplantation (HSCT) are highly intensive and associated with significant toxicity, which can influence survival and quality of life. This study aimed to analyze the incidence of gast...
Observational Study
Neoplasma. 2025 Dec;72(6):452-458. DOI:10.4149/neo_2025_251031N458 2025
PAF15 drives melanoma progression by promoting proliferation concomitant with suppression of DNA damage and apoptosis: a novel therapeutic vulnerability [0.03%]
PAF15通过促进增殖同时抑制DNA损伤和凋亡来驱动黑色素瘤进展：一种新的治疗弱点
Yacong Ji,Chongyang Li,Han Hao et al.
Yacong Ji et al.
PAF15 is an oncogene and is overexpressed across multiple malignancies. However, its biological role in melanoma remains largely unclear. In this research, bioinformatics analysis (GEPIA2, TCGA, CancerSEA) confirmed transcriptional PAF15 ov...
Integrated transcriptomic and proteomic analysis reveals the mechanistic role of OST in cutaneous squamous cell carcinoma [0.03%]
整合转录组和蛋白质组分析揭示了OST在皮肤鳞状细胞癌中的作用机制
Yue Wang,Hongfang Ding,Tong Gao et al.
Yue Wang et al.
Osthole (OST) is a natural component of the traditional Chinese medicinal herb, Cnidium monnieri, that exhibits antipruritic properties and may exert effects on dermatitis. Numerous previous studies have focused on the effects of OST in tum...
LINC00324 suppresses abnormal proliferation and promotes apoptosis of leukemia cells through the miR-10b-5p/PTEN pathway [0.03%]
长链非编码RNA LINC00324通过miR-10b-5p/PTEN通路抑制白血病细胞的异常增殖并促进其凋亡
Yiyu Li,Bo Wang,Faquan Lin et al.
Yiyu Li et al.
Long non-coding RNAs (lncRNAs) are known to participate in leukemia development, but the molecular mechanisms of many remain unclear. The expression of LINC00324 was examined in peripheral blood samples from leukemia patients and in leukemi...
HERC1 attenuates gemcitabine resistance of lung cancer cells by inhibiting autophagy through KAT2A ubiquitination [0.03%]
HERC1通过KAT2A泛素化抑制自噬从而削弱肺癌细胞对吉西他滨的耐药性
Yanhong Wei,Guanghui Tian,Zhaohui Tang et al.
Yanhong Wei et al.
Lung cancer, a leading cause of death, is challenging to treat due to gemcitabine resistance. Dysregulated autophagy is associated with chemoresistance. Here, we aimed to study the mechanism of how HERC1 modulates autophagy and gemcitabine ...