BATF2 reverses multidrug resistance of gastric cancer cells and centrosome clustering by suppressing ATM phosphorylation [0.03%]
Wei Yang,Jianlin Song,Lixia Jiang et al.
Wei Yang et al.
Chromosome instability (CIN) is a major contributor to drug resistance and recurrence. As a crucial mechanism of CIN, centrosome clustering has emerged as a promising therapeutic strategy. However, the roles and regulatory mechanisms of cen...
circRNA circ-ZEB1 promotes gallbladder carcinomas progression by regulating the miR-144-3p/ZEB2 axis [0.03%]
Luoshun Huang,Yang Zhang,Fan Yang et al.
Luoshun Huang et al.
Gallbladder cancer (GBC) is the most common and aggressive type of tumor occurring in the biliary system. Several studies have indicated the possible functions of circular RNAs (circRNAs) in GBC tumorigenesis. This research aimed to explore...
Xiaomin Wu,Yuyou Hu,Xiuyu Ji et al.
Xiaomin Wu et al.
Cancer stemness is a major therapeutic challenge in oncology. This study investigated the functional role and molecular mechanism of cell division cycle-associated 8 (CDCA8) in non-small cell lung cancer (NSCLC) stem cells. In this study, N...
Yun Tao,Yaxun Wu,Xingsong Zhang et al.
Yun Tao et al.
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma in the world. It exhibits high heterogeneity and invasiveness and is prone to developing treatment resistance. Therefore, there is an urgent need for good...
V9302, an inhibitor of glutamine transport, suppresses proliferation and migration, and induces apoptosis in non-small cell lung cancer cells through ROS-mediated mTOR/p70S6K pathway [0.03%]
谷氨酰胺转运抑制剂V9302通过ROS介导的mTOR/p70S6K通路抑制非小细胞肺癌细胞增殖、迁移并诱导凋亡
Shuo Li,Xingyu Zhang,Teng Chen et al.
Shuo Li et al.
This study aimed to investigate the effects and underlying mechanisms of V9302, an inhibitor of glutamine transport, on non-small cell lung cancer (NSCLC) cells. Proliferation was assessed using the cell counting kit-8, colony formation, an...
Isoguanosine exerts anticancer effects in Huh-7 cells by modulating ROS-dependent MAPK and AKT signaling [0.03%]
异鸟苷通过调节ROS依赖性的MAPK和AKT信号在Huh-7细胞中发挥抗肿瘤作用
An-Qi Wang,Xiao-Yu Jin,Ying-Hua Luo et al.
An-Qi Wang et al.
Isoguanosine (ISO) is a naturally occurring bioactive compound with multiple pharmacological properties. In this study, the inhibitory effects of ISO on hepatocellular carcinoma (HCC) cells and its underlying molecular mechanisms were inves...
Prognostic model based on mitochondrial genes highlights ABCD3 as a potential therapeutic target in colorectal cancer [0.03%]
基于线粒体基因的预后模型强调ABCD3可能是结直肠癌潜在治疗靶点
Shuyu Chen,Youyue Li,Wenbo Ding et al.
Shuyu Chen et al.
Studies have shown that abnormal mitochondrial function is closely associated with the development and progression of colorectal cancer (CRC); however, prognostic models based on mitochondria-related genes are still lacking. We systematical...
CDH17 facilitates β-catenin nuclear translocation to reduce drug sensitivity in cisplatin-resistant gastric cancer cells [0.03%]
CDH17通过促进β-catenin核转位提高胃癌细胞顺铂耐药性
Meng Liu,Zheng Han,Ziqiang Zhong et al.
Meng Liu et al.
Chemoresistance greatly impairs the effectiveness of chemotherapy in gastric cancer (GC) patients. According to our prior results, Cadherin-17 (CDH17) contributes to chemoresistance in GC through activating the Wnt/β-catenin pathway; howev...
(-)-Guaiol Inhibits Lung Cancer via PPARG-Dependent Fatty Acid Oxidation [0.03%]
(-)-龙脑通过PPARG依赖性脂肪酸氧化抑制肺癌
Zhen-Yu Zhao,Bo Zhang,Ying-Bin Luo et al.
Zhen-Yu Zhao et al.
The objective of this study was to explore the effect of (-)-guaiol on lung cancer using experimental validation, mRNA sequencing, and network pharmacology. Potential targets of (-)-guaiol and lung cancer were identified through SwissTarget...
Research progress on the role of DDR1 in cancer and targeted therapy strategy [0.03%]
DDR1在癌症中的研究进展及其靶向治疗策略
Xiaoying Guan,Yajie Zhang,Xiaoli Guan et al.
Xiaoying Guan et al.
Discoidin domain receptor 1 (DDR1) is a receptor tyrosine kinase activated by various types of collagen. Abnormal activation of DDR1 is closely related to the occurrence and development of solid tumors and plays an important role in the reg...