[Interleukin-6 From molecular mechanisms of signal transduction to physiological properties and therapeutic targeting] [0.03%]
从信号转导分子机制到生理功能及治疗靶向——细胞因子白细胞介素-6(IL-6)综述
M S Drutskaya,M A Nosenko,K-S N Atretkhany et al.
M S Drutskaya et al.
Interleukin-6 (IL-6)--one of the most important pro-inflammatory cytokines that has a broad spectrum of immunoregulatory properties. Molecular mechanisms of signal transduction of IL-6 and its receptor, which were previously established, ha...
I G Laptev,A Ya Golovina,P V Sergiev et al.
I G Laptev et al.
Genomewide mapping of posttranscriptional modification in eukaryotic RNA allowed to reveal tens of thousands modification sites. Among modified nucleotides of eukaryotic RNA 6-methyladenosine, 5-methylcytidine, pseudouridine, inosine, and o...
[Super-enhancers. Are they regulators of regulatory genes of development and cancer?] [0.03%]
超级增强子。它们是发育和癌症中的调控基因的调节因子吗？
D A Didych,D V Tyulkina,V V Pleshkan et al.
D A Didych et al.
Enhancers make up a huge class of genome regulatory elements that play an important role in the formation and maintenance of specific patterns of gene transcriptional activity in all types of cells. In recent years, high-throughput methods ...
K N Kashkin,E D Sverdlov
K N Kashkin
This review is devoted to the mechanisms of transcriptional pause and poised state of RNA polymerase II. Features of poised promoters and chromatin are considered in brief. Role of regulated transcriptional pause as discrete and important s...
M T Bondarenko,N V Maluchenko,M E Valieva et al.
M T Bondarenko et al.
FACT is heterodimer protein complex and histone chaperone that plays an important role in maintaining and modifying chromatin structure during various DNA-dependent processes. FACT is involved in nucleosome assembly de novo and in the prese...
[A comparative analysis of various antigenic proteins found in Haemonchus contortus--a review] [0.03%]
[对不同钩虫抗原蛋白的研究比较--综述]
I R Tak,J S Dar,S A Dar et al.
I R Tak et al.
Many innovative researches on the development and introduction of recombinant vaccines against many economically important parasites were carried out in the 20th century. Research continues to hold promise with the development of immunologi...
[Web server for prediction of miRNAs and their precursors and binding sites] [0.03%]
[用于预测microRNA及其前体和结合位点的网络服务器]
P S Vorozheykin,I I Titov
P S Vorozheykin
A microRNA (miRNA) is a small noncoding RNA molecule about 22 nucleotides in length. The paper describes a web server for predicting miRNAs and their precursors and binding sites. The predictions are based on either sequence similarity to k...
[Computational analysis of a cys-loop ligand gated ion channel from the green alga Chlamydomonas reinhardtii] [0.03%]
[来自绿藻小立憲彌綱的cys-loop配体门控离子通道的计算分析]
Ashutosh Mukherjee
Ashutosh Mukherjee
Plants possess several neurotransmitters with well-known physiological roles. Currently only receptors for glutamate were reported to be found in plants, while receptors for acetylcholine, serotonin and GABA have not yet been reported. In a...
[Influence of M680I and M694V mutations on pyrin's domain B30.2 tertiary structure and it's complex formation ability with caspase-1] [0.03%]
M680I和M694V突变对Pyrin蛋白结构域B30.2三级结构的影响及其与Caspase-1的复合体形成能力研究
G G Arakelov,O V Osipov,K B Nazaryan
G G Arakelov
The M680I and M694V mutations located in the B30.2 pyrin domain are responsible for the manifestation of the most common forms of Familial Mediterranean fever. It is well known that a malfunction of the pyrin-caspase-1 complex is the main c...
[Probabilistic calculations of biomolecule charge states that generate mass spectra of multiply charged ions] [0.03%]
生成多电荷离子生物大分子质谱的电荷态的概率计算方法研究
M O Raznikova,V V Raznikov
M O Raznikova
In this work, information relating to charge states of biomolecule ions in solution obtained using the electrospray ionization mass spectrometry of different biopolymers is analyzed. The data analyses have mainly been carried out by solving...