T A Shchelkunova,I A Morozov
T A Shchelkunova
Progesterone and its analogs may exert opposite effects on cell proliferation, apoptosis, and epithelial-mesenchymal transition, leading to higher cell motility and metastasis. Their ultimate effect is determined by a number of factors: the...
M Ashwini,S B Murugan,S Balamurugan et al.
M Ashwini et al.
"Molecular cloning" meaning creation of recombinant DNA molecules has impelled advancement throughout life sciences. DNA manipulation has become easy due to powerful tools showing exponential growth in applications and sophistication of rec...
[Receptor tyrosine kinase KIT may regulate expression of genes involved in spontaneous regression of neuroblastoma] [0.03%]
[KIT受体酪氨酸激酶可能通过调节自发消退的神经母细胞瘤相关基因表达发挥促凋亡作用]
T D Lebedev,P V Spirin,M V Suntsova et al.
T D Lebedev et al.
Hallmark of neuroblastoma is an ability of this malignant tumor to undergo spontaneous regression or differentiation into benign tumor during any stage of the disease, but it is little known about mechanisms of these phenomena. We studied e...
[Comparative study of therapy targeted genes expression in neuroblastoma cell lines] [0.03%]
靶向基因治疗神经母细胞瘤细胞系的比较研究
T D Lebedev,P V Spirin,N N Orlova et al.
T D Lebedev et al.
In this study we evaluated c-kit, VEGFA, and MYC gene expression level in seven neuroblastoma stable cell lines: SK-N-SH, SK-N-BE, SK-N-AS, SH-SY5Y, Kelly, IMR-32, and LAN-1. Expression levels of these genes can serve as diagnostic factors ...
[Cytotoxicity mechanism of the RNase Sa cationic mutants involves inhibition of potassium current through Ca2+-activated channels] [0.03%]
[RNase Sa阳离子突变体的细胞毒机制涉及钙激活钾通道介导的钾电流抑制]
V A Mitkevich,C N Pace,A Koschinski et al.
V A Mitkevich et al.
Bacterial ribonucleases (RNases) are considered to be potential anticancer agents. One of most important determinants of RNase cytotoxicity is the net charge of the molecule. In this work a set of mutants of the RNase from Streptomyces aure...
[Photoreactivation of UV-irradiated Escherichia coli K12 AB1886 uvrA6 with assistance of luminescence of Photobacterium leiognathi Luciferase] [0.03%]
荧光杆菌萤火虫酶诱导的UV照射大肠杆菌AB1886光复活作用研究
O E Melkina,V Yu Kotova,M N Konopleva et al.
O E Melkina et al.
The bioluminescence induced by luciferases of marine bacteria promotes repair of UV damaged DNA of Escherichia coli AB1886 uvrA6. It is shown that bacterial photolyase that implements photoreactivation activity is the major contributor to D...
[Heat-shock protein HSP70 protects neuroblastoma cells SK-N-SH from the neurotoxic effects hydrogen peroxide and the β-amyloid peptide] [0.03%]
heat shock蛋白hsp70保护神经母细胞瘤sk-n-sh细胞免受过氧化氢和β-淀粉样蛋白的毒性损伤作用
M M Yurinskaya,V A Mit&#x;kevich,E P Barykin et al.
M M Yurinskaya et al.
Neuronal cell death in Alzheimer's disease is associated with the development of oxidative stress caused by the reactive oxygen species (ROS), which can be generated as a result of the effect of beta-amyloid peptides. One of the sources of ...
N N Mazurenko,I V Tsyganova,A A Lushnikova et al.
N N Mazurenko et al.
Melanoma is the most lethal malignancy of skin, which is comprised of clinically relevant molecular subsets defined by specific "driver" mutations in BRAF, NRAS, and KIT genes. Recently, the better results in melanoma treatment were obtaine...
[Recruiting of insulator protein ZIPIC of Drosophila melanogaster to minor binding sites in vivo depends on other DNA-binding transcription factors] [0.03%]
绝缘蛋白ZIPIC在果蝇中的结合靶点及其作用机制研究
N A Zolotarev,O V Kyrchanova,O G Maksimenko et al.
N A Zolotarev et al.
ZIPIC insulator protein of Drosophila has seven zinc finger domains at the C-terminus. Some of this zinc fingers are involved in binding of specific DNA sequence: CAGGGCTG. ZIPIC can interact only in vivo with minor form of this site (subst...
[Mesenchymal stem cells expressing cytosine deaminase inhibit growth of murine melanoma B16F10 in vivo] [0.03%]
表达胞苷脱氨酶的间充质干细胞抑制小鼠黑色素瘤B16F10的生长作用
L S Krasikova,S S Karshieva,I B Cheglakov et al.
L S Krasikova et al.
The aim of this study was to estimate the efficacy of mesenchymal stem cell-based suicide gene therapy in mice bearing murine melanoma B16F10. Adipose mesenchymal stem cells (MSCs) were transfected with plasmid constructs expressing cytosin...