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[Euphorbia tirucalli提取物抗增殖作用的验证——乳腺癌细胞系中的研究]
M Choene,L Motadi
M Choene
Medicinal plant extracts have recently attracted attention of modern medical science research due to their non-lethal activity. Currently, up to 50% of the world drugs including chemotherapeutic drugs such as taxol and camptothecin are deri...
[Identification of a Novel Calcium (Ca^(2+))-Activated Chloride Channel Accessory Gene in Xenopus laevis] [0.03%]
识别Xenopus laevis新型钙激活氯通道辅助基因
R M Lee,S M Jeong
R M Lee
Calcium (Ca^(2+))-activated chloride channel accessories (CLCAs) are putative anion channel-related proteins with diverse physiological functions. Exploring CLCA diversity is important for prediction of gene structure and function. In an ef...
[Genes for Fibrogenesis in the Determination of Susceptibility to Myocardial Infarction] [0.03%]
纤维化基因在决定心肌梗死易感性中的作用
I A Goncharova,O A Makeeva,M V Golubenko et al.
I A Goncharova et al.
A group of patients with ischemic heart disease and myocardial infarction (N = 156) and a reference population sample (N = 300) were genotyped for 58 single nucleotide polymorphisms (SNPs) in the genes involved in extracellular matrix funct...
[Evaluation of GPx1 Pro198Leu Polymorphism in Idiopathic Male Infertility] [0.03%]
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M A Mazjin,Z Salehi,F Mashayekhi et al.
M A Mazjin et al.
Infertility is defined as failure to conceive a child after 1 year of unprotected regular sexual intercourse. Approximately half of all cases of infertility are caused by factors related to the male. In nearly 50% of infertile men it is not...
A A Zharikova,A A Mironov
A A Zharikova
The discovery of small noncoding RNAs and their roles in a variety of regulatory mechanisms have led many scientists to look at the principles of functioning of the cells on a completely different side. Small RNA molecules play key roles in...
D S Kravchenko,E I Frolova,J E Kravchenko et al.
D S Kravchenko et al.
High heterogeneity is characteristic of oncology diseases, often complicating the choice of optimal anticancer treatment. One cancer type may combine tumors differing in histogenesis, genetic lesions, and mechanism of cell transformation. D...
[Induction of Unspecific Permeabilization of Mitochondrial Membrane and Its Role in Cell Death] [0.03%]
线粒体膜潜在孔形成的诱导及其在细胞死亡中的作用
E A Novoderezhkina,B D Zhivotovsky,V G Gogvadze
E A Novoderezhkina
Mitochondria participate in various vital cellular processes. Violation of their functions can lead to the development of cardiovascular and neurodegenerative diseases and malignancies. One of the key events responsible for mitochondrial da...
[Methods to Biosynthesize Mammalian Selenocysteine-Containing Proteins in vitro] [0.03%]
[体外生物合成哺乳动物硒半胱氨酸蛋白的方法]
E G Varlamova,S V Novoselov
E G Varlamova
The main problem in studying mammalian selenocysteine-containing proteins is that the proteins are difficult to obtain in a recombinant form because the amino acid selenocysteine (Sec), which is their component, is encoded by TGA, which is ...
[Hormone Resistance and Neuroendocrine Differentiation Due to Accumulation of Genetic Lesions during Clonal Evolution of Prostate Cancer] [0.03%]
[前列腺癌克隆演化过程中遗传病变积累所致的激素抵抗和神经内分泌分化]
D S Mikhaylenko,G D Efremov,A V Sivkov et al.
D S Mikhaylenko et al.
Progression of malignant tumors is largely due to clonal evolution of the primary tumor, clones acquiring different sets of molecular genetic lesions. Lesions can confer a selective advantage in proliferation rate or metastasis on the tumor...
S M Li
S M Li
Tyrosyl phosphorylation participates in various pathological and physiological processes, which are regulated by protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). The Src homology-2 domain containing phosphatase SHP2...