S A Proshkin,A S Mironov
S A Proshkin
[Creation of DNA vaccine vector based on codon-optimized gene of rabies virus glycoprotein (G protein) with consensus amino acid sequence] [0.03%]
基于狂犬病毒糖蛋白共识氨基酸序列的密码子优化基因的DNA疫苗载体构建
E S Starodubova,Y V Kuzmenko,A A Latanova et al.
E S Starodubova et al.
An optimized design of the rabies virus glycoprotein (G protein) for use within DNA vaccines has been suggested. The design represents a territorially adapted antigen constructed taking into account glycoprotein amino acid sequences of the ...
[Overexpression, homology modeling and coenzyme docking studies of the cytochrome P450nor2 from Cylindrocarpon tonkinense] [0.03%]
[产黄腐轮枝菌P450nor2基因的异源过量表达、同源建模及辅酶对接研究]
N Li,Y Z Zhang,D D Li et al.
N Li et al.
Cytochrome P450nor catalyzes an unusual reaction that transfers electrons from NADP/NADPH to bound heme directly. To improve the expression level of P450nor2 from Cylindrocarpon tonkinense (C.P450nor2), Escherichia coli system was utilized ...
[Binding of 1-substituted carbazolyl-3,4-dihydro-β-carbolines with DNA: Molecular dynamics simulation and MM-GBSA analysis] [0.03%]
[1-取代咔唑基-3,4-二氢-β-咔啉与DNA的结合：分子动力学模拟和MM-GBSA分析]
M Sargolzaei,M Afshar,M N Jorabchi
M Sargolzaei
Molecular Mechanics-Generalized Born-Solvent Accessibility free energy calculations were used to analyse DNA binding affinity of 1-substituted carbazolyl-3,4-dihydro-β-carboline molecules. In this study, DNA structure with sequence of d(CG...
[Nonstructural protein 1 of tick-borne encephalitis virus activates the expression of immunoproteasome subunits] [0.03%]
蜱传脑炎病毒非结构蛋白1能够激活免疫蛋白酶体亚基表达
Y V Kuzmenko,E S Starodubova,G G Karganova et al.
Y V Kuzmenko et al.
The interaction of viral proteins with host cell components plays an important role in antiviral immune response. One of the key steps of antiviral defense is the formation of immunoproteasomes. The effect of nonstructural protein 1 (NS1) o...
[Ribonuclease binase induces death in T-cell acute lymphoblastic leukemia cells by apoptosis] [0.03%]
核糖核酸酶binase通过诱导凋亡杀伤T细胞急性淋巴细胞白血病细胞
K M Burnysheva,I Yu Petrushanko,P V Spirin et al.
K M Burnysheva et al.
Bacterial ribonuclease binase is a potential anticancer agent. In the present study, we have determined the toxic effect of binase towards cell lines of T-cell acute lymphoblastic leukemia Jurkat and CEMss. We have shown that binase induces...
[Xenopus laevis peroxiredoxins: Gene expression during development and characterization of the enzymes] [0.03%]
非洲爪蟾过氧化氢酶基因表达及蛋白特性分析
M G Sharapov,V I Novoselov,V K Ravin
M G Sharapov
Reactive oxygen species (ROS) are produced via catabolic and anabolic processes during normal embryonic development, and ROS content in the cell is maintained at a certain level. Peroxiredoxins are a family of selenium-independent peroxidas...
[Selection of microRNA for providing tumor specificity of transgene expression in cancer gene therapy] [0.03%]
选择microRNA以期针对肿瘤特异性表达转基因的癌症基因治疗研究进展
M V Shepelev,S V Kalinichenko,P N Vikhreva et al.
M V Shepelev et al.
The use of tumor-specific microRNA loss to inhibit transgene expression in normal cells is considered as a way to increase the specificity of gene-therapeutic antitumor drugs. This method assumes the introduction of recognition sites of sup...
[PHF10 isoforms are phosphorylated in the PBAF mammalian chromatin remodeling complex] [0.03%]
[ PHF10 基因的各种转录本在染色质重塑复合体PBAF中发生磷酸化]
A V Brechalov,M E Valieva,S G Georgieva et al.
A V Brechalov et al.
Chromatin remodeling complex PBAF(SWI/SNF) alters the structure of chromatin and controls gene expression. PHF10 is a specific subunit of PBAF complex and is expressed as four isoforms in mammalian cells. We demonstrated that all isoforms a...
[Hydrogen peroxide induces oxidative stress and the mitochondrial pathway of apoptosis in RAT intestinal epithelial cells (IEC-6)] [0.03%]
双氧水诱导大鼠肠上皮细胞氧化应激和线粒体凋亡途径
L Xu,S S He,D Y Li et al.
L Xu et al.
In order to investigate the mechanism of apoptosis in rat intestinal epithelial cells (IEC-6) induced by hydrogen peroxide (H(2)O(2)), IEC-6 cells were subjected to 20 μmol/L H(2)O(2) and cell proliferation activity was determined using 3-...