[Mutation frequencies in HIV-1 subtype-A genome in regions containing efficient RNAi targets] [0.03%]
[HIV-1亚型A基因组中有效RNAi靶向区域的突变频率]
Y V Kravatsky,V R Chechetkin,D M Fedoseeva et al.
Y V Kravatsky et al.
The development of gene-therapy technology using RNAi for AIDS/HIV-1 treatment is a prospective alternative to traditional anti-retroviral therapy. RNAi targets could be selected in HIV-1 transcripts and in CCR5 mRNA. Previously, we experim...
[Detection of BCR-ABL gene mutations in chronic myeloid leukemia using biochips] [0.03%]
采用生物芯片检测慢性粒细胞白血病患者BCR-ABL基因突变
A Yu Ikonnikova,Yu E Yatsenko,O S Kremenetskaya et al.
A Yu Ikonnikova et al.
A biochip-based method was developed to identify the BCR-ABL mutations that affect the thyrosine kinase domain and determine resistance to targeted therapy with thyrosine kinase inhibitors. The method is based on RT-PCR followed by allele-s...
[Production of recombinant human interleukin-38 and its inhibitory effect on the expression of proinflammatory cytokines in THP-1 cells] [0.03%]
重组人白介素38的制备及其对THP-1细胞促炎因子表达的抑制作用
X L Yuan,Y Li,X H Pan et al.
X L Yuan et al.
Interleukin (IL)-38 is the latest member of the IL-1 cytokine family. However, as a result of lacking efficient method to generate relatively large quantity of IL-38, its precise functions are poorly understood. In the present study, the cl...
[SPINK3: A novel growth factor that promotes rat liver regeneration] [0.03%]
[SPINK3：一种促进大鼠肝再生的新生长因子]
C F Chang,J Yang,X F Li et al.
C F Chang et al.
Serine peptidase inhibitor, Kazal type 3 (SPINK3) is a trypsin inhibitor, and also a growth factor that has an identical structure to epidermal growth factor (EGF), which could combine with epidermal growth factor receptor (EGFR) to promote...
[Panel of X-linked single-nucleotide polymorphic markers for DNA identification (XSNPid) based on multiplex genotyping by multilocus PCR and MALDI-TOF mass spectrometry] [0.03%]
基于多重PCR和基质辅助激光解析离子化飞行时间质谱多基因分型建立的DNA个体识别X-染色体单核苷酸多态性标记基因座组合(XSNPid)
V A Stepanov,K V Vagaitseva,V N Kharkov et al.
V A Stepanov et al.
Human genetic markers linked with the X chromosome (X-linked) are used in the field of population and medical genetics, as well as for DNA identification of individuals in forensic science and forensic medicine. We proposed an XSNPid panel ...
[Functional analysis of Grp and Iris, the gag and env domesticated errantivirus genes, in the Drosophila melanogaster genome] [0.03%]
果蝇基因组中grp和iris的功能分析
P A Makhnovskii,I V Kuzmin,L N Nefedova et al.
P A Makhnovskii et al.
Drosophila melanogaster is the only invertebrate that contains endogenous retroviruses, which are called errantiviruses. Two domesticated genes, Grp and Iris, which originate from errantivirus gag and env, respectively, have been found in t...
V V Senichkin,G S Kopeina,A V Zamaraev et al.
V V Senichkin et al.
The main objective of anticancer treatment is the elimination of degenerated cells by the induction of programmed cell death. Various chemotherapy drugs and radiation are able to activate cell death mechanisms in tumors. However, unfortunat...
[VLP vaccines and effects of HIV-1 Env protein modifications on their antigenic properties] [0.03%]
[关于HIV-1包膜糖蛋白（Env）的变异及其对VLP疫苗抗原性的影响]
A N Vzorov,R W Compans
A N Vzorov
An ideal protective HIV-1 vaccine can elicit broadly neutralizing antibodies, capable of preventing HIV transmission. The strategies of designing vaccines include generation of soluble recombinant proteins which mimic the native Env complex...
[Key molecular mechanisms associated with cell malignant transformation in acute myeloid leukemia] [0.03%]
[急性髓系白血病细胞恶性转化相关的关键分子机制]
N N Orlova,T D Lebedev,P V Spirin et al.
N N Orlova et al.
Cancer, along with cardiovascular disorders, is one of the most important problems of healthcare. Pathologies of the hematopoietic system are the most prevalent in patients under 30 years of age, including acute myeloid leukemia (AML), whic...
N V Koroban,A V Kudryavtseva,G S Krasnov et al.
N V Koroban et al.
Regulation of gene expression via microRNA is the key mechanism of response to biotic and abiotic stresses in plants. There are a lot of experimental data on the biological function of microRNAs in response to different stresses in various ...