O Y Rybina,E G Pasyukova
O Y Rybina
Various age-related disorders accumulate during aging, causing a decline in tissue and organ function, raising the risk of disease development, and leading to death. Age-related phenotypes are tightly related to an increase in coordinated, ...
[Adapting Mouse Genome Editing Technique from Scratch Using in utero Electroporation] [0.03%]
利用子宫内电穿孔从头开始适应小鼠基因组编辑技术
J V Popova,V D Bets,E S Omelina et al.
J V Popova et al.
Mouse genome modification requires costly equipment and highly skilled personnel to manipulate zygotes. A number of zygote electroporation techniques were reported to be highly efficient in gene delivery. One of these methods called i-GONAD...
[Expression Profiles of TRIM Family Genes in Neuronal and Glial Cell Cultures of Healthy Donors and Patients with Parkinson's Disease under Normal Conditions and Upon Neuroinflammation] [0.03%]
正常条件和神经炎症条件下健康供体和帕金森病患者神经元及神经胶质细胞培养物中TRIM家族基因的表达谱分析
V V Nenasheva,E V Novosadova,T P Gerasimova et al.
V V Nenasheva et al.
Proteins of the TRIM family are involved in both innate immunity and the nervous system processes and may play an important role in the development of neurodegenerative diseases. In this work, we analyzed the expression of 35 genes of the T...
[New Epigenetic Markers of Age-Dependent Changes in the Cardiovascular System] [0.03%]
心血管系统年龄依赖性变化的新表观遗传标志物
L M Ermakova,E A Davydova,E V Kondakova et al.
L M Ermakova et al.
Cardiovascular diseases remain a predominant global cause of mortality, with a noteworthy rise in the risk of morbidity with advancing age. Besides, it accompanied by a phenomenon of disease rejuvenation in the circulatory system. Currently...
[Antiglycation Activity of Isoindole Derivatives and Its Prediction Using Frontier Molecular Orbital Energies] [0.03%]
异吲哚衍生物的抗糖基化活性及其 frontier 分子轨道能预测
U M Ibragimova,N V Valuisky,S A Sorokina et al.
U M Ibragimova et al.
The extracellular matrix (ECM) provides structural support and regulates cell activity. ECM dysfunction due to metabolic pathologies or aging can lead to disease. Developing ECM protectors is crucial for the etiological prevention and treat...
[Surface-Enhanced Raman Scattering to Improve the Sensitivity of the MTT Assay] [0.03%]
利用表面增强拉曼散射提高MTT分析的灵敏度
V A Mushenkov,D A Lukyanov,N F Meshcheryakova et al.
V A Mushenkov et al.
Currently, empirical therapy regimens are often used in the treatment of infectious diseases that are not based on data on pathogen resistance. One of the main reasons for the unjustified prescription of antibacterial drugs is the lack of r...
A V Lioznova,Yu A Medvedeva
A V Lioznova
DNA methylation is one of the most important mechanisms closely involved in the epigenetic regulation of gene expression. However, the relationship between DNA methylation and expression is not completely understood. There are reported exam...
[Distribution of β-Lactamase-Producing Enterobacterales among Patients in Surgical and Therapeutic Departments of a Multidisciplinary Hospital] [0.03%]
多学科医院外科和治疗病房患者中产生β内酰胺酶的肠杆菌目细菌的分布情况
S Yu Meshchurova,A G Korobova,L M Samokhodskaya
S Yu Meshchurova
Adequate empiric therapy is difficult to choose without monitoring the local distribution of antibiotic-resistant bacteria in each hospital. The frequency of β-lactamase-producing Enterobacterales was compared in patients of therapeutic an...
[Antibiotic Resistance Genes in Cattle Gut Microbiota: Influence of Housing Conditions] [0.03%]
牛肠道微生物群中的抗生素抗性基因：饲养条件的影响
Sh A Begmatov,A V Beletsky,A L Rakitin et al.
Sh A Begmatov et al.
Resistance to antimicrobial drugs is an urgent problem not only in public health, but also in animal husbandry. The widespread use of antimicrobials in feed additives is one of the main reasons for the rapid spread of antibiotic resistance ...
[Identification of the Clinical Isolate CCGC 19/16 as Bacillus cytotoxicus] [0.03%]
临床分离株CCGC 19/16的巴氏杆菌毒力基因鉴定
N B Polyakov,D S Karpov,M V Zubasheva et al.
N B Polyakov et al.
Bacillus cereus sensu lato comprises genetically, morphologically, and physiologically similar gram-positive spore-forming bacterial species with high pathogenic potential, such as B. anthracis, B. cereus, and B. thuringiensis. Toxin-produc...