[Small Nucleolar RNAs and Long Non-Coding RNAs of the SNHG Family in the Pathogenesis of Ovarian Cancer] [0.03%]
[小核仁RNA和SNHG家族长非编码RNA在卵巢癌发生发展中的作用]
A M Burdennyy,V I Loginov,M V Fridman et al.
A M Burdennyy et al.
The discovery of a class of long noncoding RNAs (lncRNAs), including lncRNAs of the small nucleolar RNA (snoRNA) host gene family, SNHG, has led to growing interest in the study of both snoRNAs themselves and the genes encoding them. Curren...
[Problems and Prospects of Molecular Psychogenetics in the Study of Transsexsualism] [0.03%]
[分子心理遗传学在易性症研究中的问题与前景]
A O Zhukovskii,S A Kremenitskaya,N V Solovieva et al.
A O Zhukovskii et al.
The etiology of transsexualism (TS) remains unknown today because the disease is multifactorial and is caused by a set of factors, including those affecting sexual differentiation of brain tissue during fetal development. Sexual differentia...
[Parkinson's Disease Associated with Mutations in the LRRK2 Gene: Approaches to Therapy] [0.03%]
与LRRK2基因突变有关的帕金森病的治疗途径
T S Usenko,S N Pchelina
T S Usenko
Leucine-rich repeat kinase 2 (LRRK2) belongs to the subfamily of tyrosine kinase-like kinases, the main function of which is to catalyze the transfer of γ-phosphate from ATP to the substrate in the cell due to the kinase domains. The exact...
[Components of Bacterial Cell Walls as Targets for Searching for New Antibacterial Compounds: Methods of Study] [0.03%]
细菌细胞壁组分作为抗菌药物作用靶点的研究方法学进展
E A Chingizova,O D Novikova,O Yu Portnyagina et al.
E A Chingizova et al.
In the modern-day world, antibiotic resistance is one of the most serious threats to both human health and food security. Finding new ways to prevent and overcome the formation of pathogen resistance to antibiotics is an extremely important...
[Efficient Method to Isolate High-Quality RNA from Mycelia of Toxigenic Fungi Fusarium sp] [0.03%]
高效分离毒蘑菇 Fusarium 等有毒真菌菌丝体高质量RNA的方法
A A Stakheev,D Yu Ryazantsev,N G Gabrielyan et al.
A A Stakheev et al.
A rapid and relatively cost-effective method was developed to isolate and purify RNA from mycelia of two plant-pathogenic fungal species of the genus Fusarium, F. graminearum and F. coffeatum, with different morphological and biochemical pr...
[Sample Preparation and Sequencing Efficiency of microRNA Libraries from Pituitary Adenoma Tissue and Blood Plasma of Patients with Acromegaly for the Illumina Platform] [0.03%]
垂体腺瘤组织和肢大症患者血浆的微小核糖核酸文库制备及illumina平台测序性能分析
E V Ignatieva,E S Nerubenko,O A Ivanova et al.
E V Ignatieva et al.
MicroRNAs in tissues and biological fluids represent a promising class of biomarkers for the molecular diagnostics and therapy of numerous diseases, including oncological diseases. Biomarkers based on easily accessible biological fluids, pr...
[Division of the Standard Set of Amino Acids into Groups According to Their Evolutionary Age] [0.03%]
根据进化年龄将标准氨基酸分成不同的组别
V M Efimov,K V Efimov,V Yu Kovaleva
V M Efimov
It is generally accepted that the existing set of proteinogenic amino acids encoded by the standard genetic code was formed step by step in the course of evolution. Most studies name Ala, Asp, Glu, Gly, Ile, Leu, Pro, Ser, Thr, and Val as e...
[Optimization of Cytotoxic Properties of Magnetic Nanoparticle- Based Doxorubicin Delivery System] [0.03%]
基于磁性纳米粒子的多柔比星输送系统的细胞毒性质优化研究
A I Kurtova,A V Svetlakova,O A Kolesnikova et al.
A I Kurtova et al.
Doxorubicin (DOX) is a widely used cytotoxic drug known for its high antitumor activity; however, its use is associated with side effects. The development of DOX delivery systems that can minimize systemic toxicity and enhance therapeutic e...
[πDMD Simulation as a Strategy for Refinement of AlphaFold2 Modeled Fuzzy Protein Complexes Structures] [0.03%]
[利用πDMD模拟精炼AlphaFold2构建的蛋白质复合物模型]
N G Muradyan,A A Sargsyan,V G Arakelov et al.
N G Muradyan et al.
Disordered proteins are of great interest due to their structural features, as they do not have well- defined three-dimensional structures. These proteins, often called intrinsically disordered proteins or regions, play critical roles in va...
[MLE (DHX9) Helicase Regulates the Expression of Constitutive and Inducible Isoforms of the Conserved Nuclear Receptor FTZ-F1 (NR5A3)] [0.03%]
[MLE（DHX9）解旋酶调节保守型核受体FTZ-F1（NR5A3）组成型和诱导型异构体的表达]
J V Nikolenko,S G Georgieva
J V Nikolenko
In addition to participating in dosage compensation, the MLE helicase in D. melanogaster performs many functions in the regulation of gene expression, as does its human ortholog DHX9. Many of these functions are evolutionarily conserved and...