[Effects of Various Factors on Transcription Activity of pogo Transposons in Oyster Crassostrea gigas] [0.03%]
凡纳滨螺巨臂丛跳转子文库的构建及影响活性的各种因素分析
L V Puzakova,A S Osipova,Yu N Ulupova et al.
L V Puzakova et al.
The pogo superfamily is one of the most common groups of DNA transposons. Ten pogo transposons are known to occur in the genome of the Pacific oyster Crassostrea (Magallana) gigas (Thunberg, 1793). The oyster pogo elements were shown to bel...
[Error Correction Techniques in Synthetic Oligonucleotides and Synthetic DNA] [0.03%]
合成寡核苷酸和合成DNA中的纠错技术
A N Sinyakov,E V Kostina
A N Sinyakov
Methods for correcting errors in synthetic oligonucleotides and genetic constructs derived from them are described. Methods for isolating oligonucleotides with a perfect structure from oligonucleotide pools are discussed. Methods for correc...
[Enveloped Virus Entry as a Pharmacological Target: Viral Membrane Fusion Machineries and Their Inhibitors] [0.03%]
以包膜病毒入侵作为药理学靶点：病毒膜融合机器及其抑制剂
S V Cheresiz,E A Ulyanova,A G Pokrovsky
S V Cheresiz
Enveloped virus entry into the host cell mediated by the viral fusion glycoproteins represents an earliest step in viral infection, the inhibition of which offers a number of advantages over the antivirals with other mechanisms of action. V...
[In silico Screening of Protein-Protein Interaction Modulators Using the p53 and 14-3-3y Proteins as an Example] [0.03%]
[p53和14-3-3Y蛋白质为例的蛋白质-蛋白质相互作用调节剂的计算机筛选]
A A Sargsyan,N G Muradyan,V G Arakelov et al.
A A Sargsyan et al.
The study of the p53 protein and its interactions with other proteins is key to understanding the mechanisms by which p53 affects tumorigenesis. Mutations in the TP53 gene, which occur in approximately 50% of human cancers, often disrupt it...
[Immobilization of Protein Macromolecules in Biochip Cells Made of Various Polymers] [0.03%]
[用各种高分子材料制作生物芯片反应池 immobilize蛋白质大分子]
G F Shtylev,I Yu Shishkin,V A Vasiliskov et al.
G F Shtylev et al.
Microarrays with immobilized protein probes are used to analyze protein samples. Selection of materials for biochip fabrication, functionalization of the carrier surface, construction of ordered cell matrices, immobilization of protein mole...
[CDK8/19 in Stress Response in Mouse Embryonic Fibroblast Model] [0.03%]
[Cdk8/CycC在应激模型鼠胚胎纤维细胞中的表达]
E A Varlamova,T A Kirukhina,A K Isagulieva et al.
E A Varlamova et al.
Transcriptional cyclin-dependent kinases 8 and 19 (CDK8 and CDK19) are enzymatic components of the Mediator complex. CDK19 is presumably a minor paralog of CDK8 and is thought to compensate for lack of CDK8 in certain cases, but evidence fo...
[Immunization of Mice with the pVAXrbd DNA Vaccine by Jet Injection Induces a Stronger Immune Response and Protection against SARS-CoV-2 Compared to Intramuscular Injection by Syringe] [0.03%]
与注射相比，使用Jet Inject器进行pVAXrbdDNA疫苗肌肉免疫诱导更强的免疫反应和抗SARS-CoV-2保护力
D N Kisakov,M B Borgoyakova,L A Kisakova et al.
D N Kisakov et al.
During the COVID-19 pandemic, it became clear that, to ensure global health security, it is essential to have a developed platform that can be used to develop a safe, low-cost, effective vaccine quickly. DNA vaccines have several advantages...
Comparative Study
Molekuliarnaia biologiia. 2025 May-Jun;59(3):453-468. DOI: 2025
[The NS1 Protein of the Tick-Borne Encephalitis Virus and Extracellular Vesicles from NS1-Expressing Cells: Effect on Expression of Genes of the Innate Immune Response in Neuroblastoma and Glioblastoma Cells] [0.03%]
[由蜱传脑炎病毒NS1蛋白和表达NS1细胞来源的胞外囊体对神经母细胞瘤及胶质母细胞瘤细胞天然免疫反应基因表达的影响]
Y V Kuzmenko,A A Latanova,V L Karpov et al.
Y V Kuzmenko et al.
Infection with tick-borne encephalitis virus (TBEV) can lead to severe neurological complications largely associated with the activation of innate immunity and inflammatory reactions in the tissues of the nervous system. In this regard, the...
[Needle-Free Jet-Delivered mRNA-Vaccine Encoding Influenza A(H1N1)pdm09 Hemagglutinin Protects Mice from Lethal Virus Infection] [0.03%]
[无需针头的流感A（H1N1）大流行型血凝素信使rna疫苗对其它毒株具有保护作用]
S V Sharabrin,A A Ilyichev,D N Kisakov et al.
S V Sharabrin et al.
Seasonal influenza is an acute respiratory illness caused by the influenza A and B viruses that circulate worldwide. Due to high variability, new strains of the virus emerge every year. Therefore, vaccine formulation has to be revised every...
[Expression of Nonstructural Protein 1 of the Tick-Borne Encephalitis Virus Stimulates the Secretion of Extracellular Vesicles Capable of Activating IL-1β Production] [0.03%]
tick-borne脑炎病毒非结构蛋白1表达促进释放能够激活IL-1β产生的外泌体
E S Starodubova,A A Latanova,Y V Kuzmenko et al.
E S Starodubova et al.
Despite active research, so far the detailed mechanisms of TBEV pathogenesis have not been fully disclosed. Recently, extracellular vesicles, especially small-sized vesicles, which have been shown to play an important role in the pathogenes...