[Analogs and Conjugates of Natural Proline-Arginine-Rich Antimicrobial Peptides: Application Potential] [0.03%]
【天然脯氨酸-精氨酸丰富的抗菌肽类似物及缀合物：应用潜力】
P R Bazhutov,Z Z Khairullina,A G Tereshchenkov et al.
P R Bazhutov et al.
Antimicrobial peptides (AMPs) and, in particular, proline-arginine-rich cationic AMPs (PrAMPs) have recently attracted attention as potential candidates for developing new-generation antibacterial drugs. This interest stems from the fact th...
[Label-Free Optical Biosensor for Analysis of Binding Kinetics of Smart Nanomaterials with Ligands] [0.03%]
[label-free光学生物传感器分析智能纳米材料与配体的结合动力学]
F A Zavalko,E N Komedchikova,O A Kolesnikova et al.
F A Zavalko et al.
Stimulus-sensitive smart materials are activated by input signals and remain inactive until they arrive. Such materials are of great interest for the analysis of biochemical data in diagnostics and therapy. To develop nanomaterial-based sma...
[Optimization of Production of Recombinant Adeno-Associated Virus Serotype 9] [0.03%]
重组腺相关病毒9型生产的优化
T I Aliev,I R Imatdinov
T I Aliev
Vectors based on adeno-associated viruses (AAV) have proven to be a convenient tool for genomic editing. However, for transgenesis of laboratory animals or gene therapy for human diseases, a high AAV titer is required. We optimized the cond...
[CG10543 Protein Is Involved in the Regulation of Transcription of Ecdysone-Dependent Genes] [0.03%]
[CG10543蛋白参与泛激素依赖性基因转录调控]
N E Vorobyova,Iu V Nikolenko,A N Krasnov
N E Vorobyova
Despite increasing data on the properties of the origins of replication, the molecular mechanisms underlying the origin recognition complex (ORC) positioning in the genome are still poorly understood. It has been suggested that the key fact...
[Regulation of Complement C3 Gene in HepG2 Human Hepatoma Cells under Oxidative Stress] [0.03%]
氧化应激下人肝癌HepG2细胞补体C3基因的调控
A V Babina,V S Shavva,A V Lisunov et al.
A V Babina et al.
Reactive oxygen and nitrogen species accumulate in cells during oxidative stress and cause oxidative damage to various cell components, including DNA, proteins, and lipids, thus leading to a number of severe diseases, such as atherosclerosi...
[DNA Double-Strand Break Repair System by a Mechanism of Non-Homologous End Joining Provides Resistance to DNA-Damaging and Oxidizing Stresses in the Yeast Debaryomyces hansenii] [0.03%]
［通过非同源末端连接的dna双链断裂修复系统可赋予酵母菌德巴利汉逊氏霉耐受脱氧核糖核酸损伤和氧化胁迫的能力］
A I Cherdantsev,K A Kulagin,A N Polyakova et al.
A I Cherdantsev et al.
The unconventional halotolerant yeast Debaryomyces hansenii is of great importance in biotechnology and the food industry, and in basic research it serves as a model for studying the molecular mechanisms of resistance to increased salinity ...
[In Vitro Reconstitution of the Staphylococcus aureus 50S Ribosomal Subunit-GTP-Binding Factor YsxC Complex for Structural Studies] [0.03%]
用于结构研究的金黄色葡萄球菌50S核糖体亚基-GTP结合因子YsxC复合物的体外重组
A D Biktimirov,M M Yusupov,K S Usachev
A D Biktimirov
Proper assembly and maturation of ribosomal subunits are critical processes that ensure functional activity, translation efficiency, and fidelity of the ribosome. The GTP-binding protein YsxC is found in many bacteria and is one of the prot...
[Assembly of a Complex of an Immature 30S Ribosomal Subunit and the Era GTPase Maturation Factor from Staphylococcus aureus In Vitro for Structural Studies] [0.03%]
人表皮生长因子受体4信号通路的鉴定及小分子抑制剂的筛选与作用机制研究
E A Klochkova,A D Biktimirov,A G Bikmullin et al.
E A Klochkova et al.
Era GTPase of Staphylococcus aureus is a ribosome maturation factor. Era GTPase is involved in the late stages of small (30S) ribosome subunit assembly and regulates formation of the entire 70S ribosome. Study of the structure of the Era an...
[The CCC Proline Codon Preceding a Stop Codon Modulates Translation Termination in Eukaryotes Depending on the Molecular Context] [0.03%]
〔CCC 前的脯氨酸密码子调控真核生物中翻译终止依赖于分子环境〕
N S Biziaev,A V Shuvalov,E Z Alkalaeva
N S Biziaev
In bacteria, glycine and proline codons, located upstream of stop codons, suppress translation termination. However, the effects of those codons in eukaryotes have not been systematically investigated. In this study, we demonstrate that pre...
[Transcriptomic Profile of the Trastuzumab-Resistant Breast Cancer Cell Line BT-474] [0.03%]
[曲妥珠单抗耐药性乳腺癌细胞系BT-474的转录组谱分析]
S A Shifon,I O Karpets,A S Chesnokova et al.
S A Shifon et al.
The development of resistance to trastuzumab in HER2-positive breast cancer is a serious clinical problem that limits the effectiveness of targeted therapy. In a significant proportion of patients, the mechanisms in the development of resis...