E S Kolegova,A A Schegoleva,L A Kononova et al.
E S Kolegova et al.
Oral cancer is an aggressive and rapidly progressive disease. The oral cavity is home to over 700 species of microorganisms that regulate metabolism, immune function, and health. There are three types of mechanisms by which bacteria may par...
[Regulation of Transcription by RNA Polymerase III Promotors in the Norm and Pathology] [0.03%]
[正常与病理状态下的RNA聚合酶III启动子转录调控]
A M Schwartz,K A Tatosyan,D V Stasenko et al.
A M Schwartz et al.
RNA polymerase III synthesizes a wide range of noncoding RNAs shorter than 400 nucleotides in length. These RNAs are involved in protein synthesis (tRNA, 5S rRNA, and 7SL RNA), maturation, and splicing of different types of RNA (RPR, MRP RN...
N S Gladysh,M A Kovalev,M S Lantsova et al.
N S Gladysh et al.
The study of molecular and genetic mechanisms of sex determination in the poplar is of interest not only in the fundamental science, but also in the applied research. In landscaping of large settlements, it is advisable to use male individu...
[Uveal Melanoma: Molecular and Genetic Mechanisms of Development and Therapeutic Approaches] [0.03%]
[眼脉络膜黑色素瘤的发展及治疗手段的分子和遗传机制]
M V Zhilnikova,O S Troitskaya,D D Novak et al.
M V Zhilnikova et al.
Uveal melanoma (UM) is a neuroectodermal tumor that results from malignant transformation of melanocytes in the eye uvea, including the iris, the ciliary body, and the choroid. UM accounts for 5% of all melanoma cases and is extremely aggre...
[The Proteome of Extracellular Membrane Vesicles from Bacillus pumilus 3-19] [0.03%]
芽胞杆菌3-19菌细胞外膜囊泡蛋白组学研究
W Kurdy,P V Zelenikhin,G Yu Yakovleva et al.
W Kurdy et al.
Production of extracellular membrane vesicles plays an important role in communication in bacterial populations and in bacteria-host interactions. Vesicles as carriers of various regulatory and signaling molecules may be potentially used as...
[A Bioinformatics Method for Identification of Human Proteases Active against Viral Envelope Glycoproteins: A Case Study on the SARS-CoV-2 Spike Protein] [0.03%]
[用于识别人源天敌蛋白酶的生物信息学方法及其对病毒包膜糖蛋白作用机制研究——以SARS-CoV-2刺突蛋白为例]
E V Matveev,G V Ponomarev,M D Kazanov
E V Matveev
Many viruses, including SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic, enter host cells through a process of cell-viral membrane fusion that is activated by proteolytic enzymes. Typically, these enzymes are host cell pro...
N I Ponomareva,S A Brezgin,A P Kostyusheva et al.
N I Ponomareva et al.
CRISPR/Cas systems are perspective molecular tools for targeted manipulation with genetic materials, such as gene editing, regulation of gene transcription, modification of epigenome etc. While CRISPR/Cas systems proved to be highly effecti...
[The Development of SpCas9 Variants with High Specificity and Efficiency Based on the HH Theory] [0.03%]
基于HH理论的高特异性和高效性SpCas9突变体开发
G H Wang,C M Wang,X J Wu et al.
G H Wang et al.
Streptococcus pyogenes Cas9 (SpCas9) is the most popular tool in gene editing; however, off-target mutagenesis is one of the biggest impediments in its application. In our previous study, we proposed the HH theory, which states that sgRNA/D...
[Latent Macrophage and Immature B Cell Lines Generated with Hygromycin-Resistant Murine Gammaherpesvirus 68 Genome Expresses Modest Levels of Viral miRNAs] [0.03%]
hygromycin抗性基因工程改造的鼠源γ疱疹病毒68潜伏感染巨噬细胞系和未成熟B淋巴细胞系表达低水平的病毒miRNA
M Kara
M Kara
Murine gammaherpesvirus 68 (MHV68) establishes latency mainly in B cells and causes lymphomas reminiscent of human gammaherpesvirus diseases in laboratory mice. To study the molecular mechanism of virus infection and how the viral determina...
[Melatonin Enhances the Effect of ABT-737 in Acute Monocytic Leukemia THP-1 Cells] [0.03%]
褪黑素增强ABT-737在急性单核细胞白血病THP-1细胞中的抑瘤效果
A I Lomovsky,Y L Baburina,R S Fadeev et al.
A I Lomovsky et al.
Melatonin (N-acetyl-5-methoxytryptamine, MEL) is a hormone synthesized by the pineal gland. Due to its oncostatic effect, it can be considered as an antitumor agent and used for combination therapy. ABT-737, a Bcl-2 inhibitor, promotes cell...