[What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins] [0.03%]
actin和肌球蛋白在细胞核内的作用-老蛋白质的新功能
A A Saidova,I A Vorobjev
A A Saidova
The functions of actin and its motor proteins myosins in the cytoplasm have been the subject of research for more than 100 years, but the existence and function of these proteins in the nucleus has been a matter of debate until recently. Re...
[Cytoplasmic mRNA Transport: Adaptors of mRNA Binding to Microtubule Motor Proteins] [0.03%]
细胞内mRNA运输：mRNA与微管马达蛋白结合的适配器分子
Y A Vdovina,S G Georgieva,D V Kopytova
Y A Vdovina
The process of mRNA localization in the cytoplasm involves the directed transport of mRNP particles using the microtubule system. This transport is mediated and regulated by specific factors-adaptors between mRNA molecules and microtubule m...
V A Kezin,E S Matyugina,S A Surzhikov et al.
V A Kezin et al.
We have previously shown that 5-arylaminouracil derivatives can inhibit HIV-1, herpesviruses, mycobacteria, and other pathogens through various mechanisms. The purpose of this study was to evaluate the potential of 5-arylaminouracils and th...
L G Bobyleva,T A Uryupina,N V Penkov et al.
L G Bobyleva et al.
Titin is a multidomain protein of striated and smooth muscles of vertebrates. The protein consists of repeating immunoglobulin-like (Ig) and fibronectin-like (FnIII) domains, which are β-sandwiches with a predominant β-structure, and also...
[Method of Inducible Knockdown of Essential Genes in OSC Cell Culture of Drosophila melanogaster] [0.03%]
[果蝇OSCAR细胞系中必需基因的诱导敲减方法]
S V Marfina,E A Mikhaleva,N V Akulenko et al.
S V Marfina et al.
An RNA interference-based method was proposed to achieve an inducible knockdown of genes essential for cell viability. In the method, a genetic cassette in which a copper ion-dependent inducible metallothionein promoter controls expression ...
[Bipolar Action of Inhibitor of Vasculogenic Mimicry on Gene Expression in Melanoma Cells] [0.03%]
血管生成模拟抑制剂的双向作用及其对黑色素瘤细胞基因表达的影响
N A Tchurikov,A A Vartanian,E S Klushevskaya et al.
N A Tchurikov et al.
Multiple exogenous or endogenous factors alter gene expression patterns by different mechanisms that are poorly understood. We used RNA-Seq analysis in order to study changes in gene expression in melanoma cells that are capable of vasculog...
[Changes in the Genome of the Tick-Borne Encephalitis Virus during Cultivation] [0.03%]
[细胞培养过程中_tick-borne_encephalitis病毒基因组的变化]
V A Ternovoi,E P Ponomareva,E V Protopopova et al.
V A Ternovoi et al.
The tick-borne encephalitis virus (TBEV) strain C11-13 (GenBank acc. no. OQ565596) of the Siberian genotype was previously isolated from the brain of a deceased person. TBEV C11-13 variants obtained at passages 3 and 8 in SPEV cells were in...
[The rs2564978(T) Allele Associated with Severe Influenza A Disrupts the Binding Site for Myeloid Differentiation Factor PU.1 and Reduces CD55/DAF Gene Promoter Activity in Macrophages] [0.03%]
与严重流感相关的rs2564978(T)等位基因破坏髓样分化因子PU.1的结合位点并降低巨噬细胞中CD55/DAF基因启动子活性
A N Uvarova,E A Tkachenko,E M Stasevich et al.
A N Uvarova et al.
The complement inhibitor CD55/DAF is expressed on many cell types. Dysregulation of CD55 expression is associated with increased disease severity in influenza A infection and vascular complications in pathologies that involve excessive acti...
[The Expression of TP53TG1, LINC00342, MALAT1, H19, and MEG3 Long Noncoding RNAs in Type 2 diabetes mellitus] [0.03%]
2型糖尿病患者TP53TG1、LINC00342、MALAT1、H19和MEG3长链非编码RNA的表达分析
O V Kochetova,D Sh Avzaletdinova,G F Korytina
O V Kochetova
Type 2 diabetes is a complex and multifactorial metabolic disorder. The frequency of type 2 diabetes has dramatically increased worldwide. Long noncoding RNAs play a regulatory role in pathological processes of type 2 diabetes. The aim of t...
[Knockout of Hsp70 Genes Modulates Age-Related Transcriptomic Changes in Leg Muscles and Reduces the Locomotion Speed and Lifespan of Drosophila melanogaster] [0.03%]
[Hsp70基因敲除可调节果蝇腿部肌肉转录组年龄相关变化并降低其飞行速度和寿命]
I V Kukushkina,P A Makhnovskii,V G Zgoda et al.
I V Kukushkina et al.
This study investigated the effect of knockout of six Hsp70 genes (orthologues of the mammalian genes Hspa1a, Hspa1b, Hspa2, and Hspa8) on age-related changes in gene expression in the legs of Drosophila melanogaster, which contain predomin...