[Synthesis of a Bisbenzoxazole Analogue of Hoechst 33258 as a Potential GC-Selective DNA Ligand] [0.03%]
[Hoechst 33258苯并氧杂氮卓衍生物的合成及其作为潜在GC-选择性DNA配体的研究]
A F Arutyunyan,M S Aksenova,A A Kostyukov et al.
A F Arutyunyan et al.
Using a computer modeling approach, we proposed a structure for a potential GC-specific DNA ligand, which could form a complex with DNA in the minor groove similar to that formed by Hoechst 33258 at DNA AT-enriched sites. According to this ...
[Development of Biological Microchips on an Aluminum Support with Cells Made of Brush Polymers] [0.03%]
[以刷状聚合物为细胞的铝基生物芯片的研发]
I Yu Shishkin,G F Shtylev,V E Barsky et al.
I Yu Shishkin et al.
A method has been developed for manufacturing biological microchips on an aluminum substrate with hydrophilic cells from brush copolymers with the formation of a matrix of cells using photolithography. The surface of aluminum substrates was...
[ArdA Protein Specificity against Type I Restriction-Modification Systems] [0.03%]
[ArdA蛋白对I型限制修饰系统的特异性]
A A Kudryavtseva,A V Vlasov,E V Zinovev et al.
A A Kudryavtseva et al.
The ArdA DNA-mimic antirestriction proteins inhibit type I restriction-modification (RMI) systems by binding instead of DNA to RMI. The ArdA specificity to DNA methylation sites recognized by RMI complexes remains poorly understood; i.e., i...
[Drosophila melanogaster Paip2 Binds ENY2 and Interacts with the TREX-2 Complex in Histone mRNP Particles] [0.03%]
[果蝇Paip2与ENY2互作并参与组蛋白mRNP颗粒中TREX-2复合体的相互作用]
M M Kurshakova,A N Krasnov,E N Nabirochkina et al.
M M Kurshakova et al.
ENY2 is an evolutionarily conserved multifunctional protein and is a member of several complexes that regulate various stages of gene expression. ENY2 is a subunit of the TREX-2 complex, which is necessary for the export of bulk mRNA from t...
[Participation of Proteins of the CPSF Complex in Polyadenylation of Transcripts Read by RNA Polymerase III from SINEs] [0.03%]
[CPSF复合体蛋白参与RNA聚合酶III转录的SINE转录本多聚腺苷酸化]
I G Ustyantsev,O R Borodulina,D A Kramerov
I G Ustyantsev
SINEs are mobile genetic elements of multicellular eukaryotes that arose during evolution from various tRNAs, as well as from 5S rRNA and 7SL RNA. Like the genes of these RNAs, SINEs are transcribed by RNA polymerase III. The transcripts of...
[Study of the Gut Transcriptomic Response in Drosophila melanogaster with Knockdown of Gagr, Domesticated gag Gene of Errantiviruses] [0.03%]
[模式生物果蝇中宿主抗病毒基因GAGr沉默的转录组学研究]
M L Nikitina,P A Milyaeva,I V Kuzmin et al.
M L Nikitina et al.
As a result of molecular domestication of the gag gene of errantiviruses, the Gagr gene was formed in the genome of Drosophila melanogaster. It has previously been shown that the Gagr gene is transcribed at the highest level in gut tissues ...
[DNA Methylation Profiling in Aneurysm and Comorbid Atherosclerosis of the Ascending Aorta] [0.03%]
主动脉瘤及升主动脉粥样硬化并存病的DNA甲基化谱分析
I A Goncharova,A A Zarubin,S A Shipulina et al.
I A Goncharova et al.
Atherosclerosis and aneurysm of the aorta are relatively common pathological conditions that remain asymptomatic for a long period of time and have life-threatening and disabling complications. DNA methylation profiling in several regions (...
[Methylation of Long Noncoding RNA Genes SNHG6, SNHG12, and TINCR in Ovarian Cancer] [0.03%]
卵巢癌中长链非编码RNA基因SNHG6、SNHG12和TINCR的甲基化研究
S S Lukina,A M Burdennyy,E A Filippova et al.
S S Lukina et al.
Ovarian cancer (OC) develops asymptomatically and escapes diagnosis until advanced stages, the feature contributing to a higher mortality rate. New prospects of OC diagnosis and treatment have been opened in studies of the gene regulation m...
[Recombinant VLP Vaccines Synthesized in Plant Expression Systems: Current Updates and Prospects] [0.03%]
植物表达系统合成重组VLP疫苗的研究进展及前景展望
S M Rozov,E V Deineko
S M Rozov
The development and creation of a new generation vaccines based on recombinant proteins that assemble into virus-like particles (VLPs), as well as recombinant proteins in the form of nanoparticles, are promising directions in modern biotech...
N A Lunina,D R Safina,S V Kostrov
N A Lunina
The bony fish Danio rerio (zebrafish) has become one of the important vertebrate model organisms in biomedical cancer research and is used, among other things, for the development of anticancer drugs using xenotransplantation approaches. Th...