[Development of a New Inhibitor of Bacterial Cystathionine γ-Lyase Based on 6-Bromoindole and Aminothiophene] [0.03%]
基于6-溴吲哚和氨基并噻吩开发新型细菌胱硫醚γ裂解酶抑制剂
R A Novikov,D N Platonov,A Yu Belyy et al.
R A Novikov et al.
Cystathionine-γ-lyase (CSE) is a key enzyme for H2S generation in the pathogenic bacteria Staphylococcus aureus, Pseudomonas aeruginosa, etc. Suppression of CSE activity significantly increases the antibiotic susceptibility of bacteria. In...
[Synthesis and Antimicrobial Activity of Thiosulfinates and Allicin Analogues] [0.03%]
硫磺化合物和大蒜素类似物的合成及其抑菌活性研究
V M Puchkov,A D Lyfenko,V S Koval et al.
V M Puchkov et al.
Diallyl thiosulfinate (allicin) effectively inhibits the growth of various microorganisms, including antibiotic-resistant strains, so it can be considered to be a broad-spectrum antimicrobial compound. However, its instability in the bloods...
[Distribution of Antibiotic Resistance Genes in Microbial Communities: The Impact of Anthropogenic Pollution] [0.03%]
微生物群落中的抗生素抗性基因的分布：人为污染的影响
I S Sazykin,M A Sazykina,A R Litsevich
I S Sazykin
Issues related to the spread of antibiotic resistance genes in environmental microbial communities are considered. "Hotspots" of adaptive evolution, accumulation, and spread of antibiotic-resistant bacteria and genetic material of antibioti...
[Enzymes of ADP-Heptose Biosynthesis As Targets for the Creation of Broad-Spectrum Antibacterial Drugs] [0.03%]
广谱抗生素的作用靶标——ADP-庚糖生物合成酶类
T A Seregina,I Yu Petrushanko,K V Lobanov et al.
T A Seregina et al.
Solving the problem of multidrug resistance currently requires the development of nonstandard approaches, since the potential for creating new antibiotics is almost exhausted. Controlling the metabolism of a pathogen in order to increase it...
[Unveiling Neisseria gonorrhoeae Survival: Genetic Variability, Pathogenesis, and Antimicrobial Drug Resistance] [0.03%]
[揭开淋病奈瑟菌的生存机制：遗传变异，致病性和抗微生物药物耐药性]
B L Shaskolskiy,I D Kandinov,D A Gryadunov et al.
B L Shaskolskiy et al.
Despite nearly a century of therapy for gonococcal infection with a variety of antimicrobials, more than 80 million cases of the disease are reported annually worldwide. The gonorrhea pathogen, Neisseria gonorrhoeae, exhibits an exceptional...
[History of the Creation of a New Generation of Antibiotics of the Group of Polycyclic Glycopeptides] [0.03%]
新一类多环肽抗生素的诞生与发展历史
E N Olsufyeva
E N Olsufyeva
Increased resistance to polycyclic glycopeptide antibiotics has become a serious problem for chemotherapy of infections caused by resistant Gram-positive bacteria. Chemical modification of known natural antibiotics is the main direction in ...
S N Kochetkov
S N Kochetkov
Antibiotic and, more broadly, antimicrobial resistance is a naturally occurring biological phenomenon and a major public health problem. Mass emergence of drug-resistant bacterial strains was first observed in the mid-20th century. Since th...
[Molecular Ion Channel Blockers of Influenza A and SARS-CoV-2 Viruses] [0.03%]
[针对流感病毒和新型冠状病毒的分子离子通道阻滞剂]
Yu N Vorobjev
Yu N Vorobjev
Molecules were proposed to block the functional cycles of the influenza virus A and SARS-CoV- 2. The blocker molecules efficiently bind inside the M2 and E channels of influenza A and SARS-CoV-2 viruses and block diffusion of H^(+)/K^(+) io...
[Virus-Like Particles Carrying HIV-1 Env with a Modulated Glycan Composition] [0.03%]
糖基组成可调的HIV-1包膜病毒样颗粒
G A Kaevitser,E I Samokhvalov,D V Scheblyakov et al.
G A Kaevitser et al.
Previously obtained highly immunogenic Env-VLPs ensure overcoming the natural resistance of HIV-1 surface proteins associated with their low level of incorporation and inaccessibility of conserved epitopes to induce neutralizing antibodies....
[Metabolic Profile of Gut Microbiota and Levels of Trefoil Factors in Adults with Different Metabolic Phenotypes of Obesity] [0.03%]
不同代谢分型肥胖成年人肠道菌群代谢谱和trefoil因素水平分布特征分析
I M Kolesnikova,L A Ganenko,I Yu Vasilyev et al.
I M Kolesnikova et al.
Obesity is associated with changes in the gut microbiota, as well as with increased permeability of the intestinal wall. In 130 non-obese volunteers, 57 patients with metabolically healthy obesity (MHO), and 76 patients with metabolically u...