Translational control of nrf2 protein in activation of antioxidant response by oxidants [0.03%]
氧化剂激活抗氧化应答中nrf2蛋白的翻译调控
Sally E Purdom-Dickinson,Elena V Sheveleva,Haipeng Sun et al.
Sally E Purdom-Dickinson et al.
Nf-E2 related factor-2 (Nrf2) is a basic leucine zipper transcription factor that binds and activates the antioxidant response element (ARE) in the promoters of many antioxidant and detoxification genes. We found that H(2)O(2) treatment cau...
Pharmacological characterization of a novel nonpeptide antagonist for formyl peptide receptor-like 1 [0.03%]
新型非肽类福林肽受体样-1拮抗剂的药理学性质表征研究
Caihong Zhou,Song Zhang,Masakatsu Nanamori et al.
Caihong Zhou et al.
A series of quinazolinone derivatives were synthesized based on a hit compound identified from a high-throughput screening campaign targeting the human formyl peptide receptor-like 1 (FPRL1). Based on structure-activity relationship analysi...
Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8 [0.03%]
高效非肽激动剂与趋化因子受体CCR8的分子相互作用研究
Pia C Jensen,Rie Nygaard,Stefanie Thiele et al.
Pia C Jensen et al.
Most nonpeptide antagonists for CC-chemokine receptors share a common pharmacophore with a centrally located, positively charged amine that interacts with the highly conserved glutamic acid (Glu) located in position 6 of transmembrane helix...
Electrophysiological properties of cardiomyocytes isolated from CYP2J2 transgenic mice [0.03%]
由CYP2J2转基因小鼠分离的心肌细胞的电生理特性
Qingen Ke,Yong-Fu Xiao,J Alyce Bradbury et al.
Qingen Ke et al.
CYP2J2 is abundant in cardiac tissue and active in the biosynthesis of eicosanoids such as epoxyeicosatrienoic acids (EETs). To determine the effects of CYP2J2 and its eicosanoid products in the heart, we characterized the electrophysiology...
Enhancing glutamate transport: mechanism of action of Parawixin1, a neuroprotective compound from Parawixia bistriata spider venom [0.03%]
来源于Parawixia bistriata蜘蛛毒液的神经保护化合物Parawixin1增强谷氨酸转运的作用机制
Andréia Cristina Karklin Fontana,Renê de Oliveira Beleboni,Marcin Wlodzimierz Wojewodzic et al.
Andréia Cristina Karklin Fontana et al.
Previous studies have shown that a compound purified from the spider Parawixia bistriata venom stimulates the activity of glial glutamate transporters and can protect retinal tissue from ischemic damage. To understand the mechanism by which...
Regulation of glutathione synthesis via interaction between glutamate transport-associated protein 3-18 (GTRAP3-18) and excitatory amino acid carrier-1 (EAAC1) at plasma membrane [0.03%]
调控谷氨酸转运相关蛋白3-18(GTRAP3-18)与兴奋性氨基酸载体-1(EAAC1)在细胞膜上的结合以调控谷胱甘肽的合成
Masahiko Watabe,Koji Aoyama,Toshio Nakaki
Masahiko Watabe
Regulation of the cysteine transporter known as excitatory amino acid carrier-1 (EAAC1) for intracellular glutathione (GSH) content was investigated using human embryonic kidney (HEK) 293 cells as a model system. GSH content was significant...
Effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of phytoestrogens [0.03%]
乳腺癌耐药蛋白（BCRP/ABCG2）对植物雌激素处置的作用
Junichi Enokizono,Hiroyuki Kusuhara,Yuichi Sugiyama
Junichi Enokizono
The effect of breast cancer resistance protein (Bcrp/Abcg2) on the disposition of the phytoestrogens daidzein, genistein, and coumestrol was investigated using Bcrp(-/-) mice. Expression of the genes for either mouse Bcrp or human BCRP in M...
Aryl hydrocarbon receptor splice variants in the dioxin-resistant rat: tissue expression and transactivational activity [0.03%]
耐二恶英大鼠的芳香烃受体剪切变异体：组织表达和转激活作用
Ivy D Moffat,Steven Roblin,Patricia A Harper et al.
Ivy D Moffat et al.
The AHR locus encodes the aryl hydrocarbon receptor (AHR), a transcriptional regulator of multiple drug-metabolizing enzymes and mediator of toxicity of dioxin-like chemicals. The Han/Wistar (Kuopio) rat strain (H/W) is remarkably resistant...
Down-regulation of pregnane X receptor contributes to cell growth inhibition and apoptosis by anticancer agents in endometrial cancer cells [0.03%]
孕烷X受体下调通过抗癌药物抑制子宫内膜癌细胞生长和诱导凋亡的作用
Hisashi Masuyama,Hideki Nakatsukasa,Norio Takamoto et al.
Hisashi Masuyama et al.
Recent studies have revealed that pregnane X receptor (PXR) can function as a master regulator to control the expression of drug-metabolizing enzymes, cytochrome P450 3A (CYP3A) family, and members of the drug transporter family, including ...
Critical roles of residues 36 and 40 in the phenol and tertiary amine aglycone substrate selectivities of UDP-glucuronosyltransferases 1A3 and 1A4 [0.03%]
UDP-葡萄糖醛酸转移酶1A3和1A4中决定苯酚和叔胺苷元底物选择性的第36位和第40位氨基酸残基的作用机制研究
Takahiro Kubota,Benjamin C Lewis,David J Elliot et al.
Takahiro Kubota et al.
Despite high sequence identity, UGT1A3 and UGT1A4 differ in terms of substrate selectivity. UGT1A3 glucuronidates the planar phenols 1-naphthol (1-NP) and 4-methylumbelliferone (4-MU), whereas UGT1A4 converts the tertiary amines lamotrigine...