N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes [0.03%]
乙基马来酰亚胺敏感因子调节心脏肌细胞中的β2肾上腺素受体转运和信号转导
Yongyu Wang,Benjamin Lauffer,Mark Von Zastrow et al.
Yongyu Wang et al.
Recycling of G protein-coupled receptors determines the functional resensitization of receptors and is implicated in switching beta2 adrenoceptor (beta2AR) G protein specificity in cardiomyocytes. The human beta2AR carboxyl end binds to the...
Characterization of an NBS1 C-terminal peptide that can inhibit ataxia telangiectasia mutated (ATM)-mediated DNA damage responses and enhance radiosensitivity [0.03%]
一种能够抑制NBS1 C-端肽介导的ATM依赖性DNA损伤修复并增强放射敏感性的多肽的研究
Mickael J Cariveau,Xi Tang,Xiao-Li Cui et al.
Mickael J Cariveau et al.
ATM and NBS1, mutation of which lead to the human autosomal recessive diseases ataxia telangiectasia and Nijmegen breakage syndrome (NBS), respectively, are essential elements in the cellular response to DNA damage induced by ionizing radia...
Glitazones induce astroglioma cell death by releasing reactive oxygen species from mitochondria: modulation of cytotoxicity by nitric oxide [0.03%]
格列酮通过从线粒体释放活性氧诱导星形细胞瘤细胞死亡：一氧化氮对细胞毒性的调节作用
José M Pérez-Ortiz,Pedro Tranque,Miguel Burgos et al.
José M Pérez-Ortiz et al.
The glitazones (or thiazolidinediones) are synthetic compounds used in type-2 diabetes, but they also have broad antiproliferative and anti-inflammatory properties still not well understood. We described previously the apoptotic effects of ...
Suppression of osteoclastogenesis by N,N-dimethyl-D-erythro-sphingosine: a sphingosine kinase inhibition-independent action [0.03%]
N,N-二甲基-D-赤式-丝氨酸通过非鞘氨醇激酶抑制的独立机制来抑制破骨细胞生成
Hyung Joon Kim,Youngkyun Lee,Eun-Ju Chang et al.
Hyung Joon Kim et al.
N,N-Dimethyl-D-erythro-sphingosine (DMS) competitively inhibits sphingosine kinase (SPHK) and has been widely used to assess the role of SPHK during cellular events, including motility, proliferation, and differentiation. In the present stu...
Up-regulation and increased activity of KV3.4 channels and their accessory subunit MinK-related peptide 2 induced by amyloid peptide are involved in apoptotic neuronal death [0.03%]
淀粉样蛋白诱导的KV3.4通道及其配体亚单位MinK相关肽2高表达与通道活化参与凋亡性神经元死亡
A Pannaccione,F Boscia,A Scorziello et al.
A Pannaccione et al.
The aim of the present study was to investigate whether K(V)3.4 channel subunits are involved in neuronal death induced by neurotoxic beta-amyloid peptides (Abeta). In particular, to test this hypothesis, three main questions were addressed...
Novel stable camptothecin derivatives replacing the E-ring lactone by a ketone function are potent inhibitors of topoisomerase I and promising antitumor drugs [0.03%]
以酮基取代E环内酯环的喜树碱新衍生物是一类高效拓扑异构酶I抑制剂和抗肿瘤药物
Amélie Lansiaux,Stéphane Léonce,Laurence Kraus-Berthier et al.
Amélie Lansiaux et al.
The E-ring lactone is the Achilles' heel of camptothecin derivatives: although it is considered necessary for the inhibition of the enzyme topoisomerase I (topo1), the opening of the lactone into a carboxylate abolishes the generation of to...
Caffeine inhibits adenosine-induced accumulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and interleukin-8 expression in hypoxic human colon cancer cells [0.03%]
咖啡因抑制低氧诱导的大肠癌细胞HIF-1α、VEGF和IL-8的表达
Stefania Merighi,Annalisa Benini,Prisco Mirandola et al.
Stefania Merighi et al.
Frequent coffee consumption has been associated with a reduced risk of colorectal cancer in a number of case-control studies. Coffee is a leading source of methylxanthines, such as caffeine. The induction of vascular endothelial growth fact...
Bradykinin-induced nuclear factor of activated T-cells-dependent transcription in rat dorsal root ganglion neurons [0.03%]
缓激肽诱导的活化T细胞核因子依赖性转录在大鼠背根神经节神经元中的作用
Joshua G Jackson,Yuriy M Usachev,Stanley A Thayer
Joshua G Jackson
Bradykinin produced at sites of tissue injury and inflammation elicits acute pain and alters the sensitivity of nociceptive neurons to subsequent stimuli. We tested the hypothesis that bradykinin could elicit long-lasting changes in nocicep...
Multidrug resistance proteins 2 and 3 provide alternative routes for hepatic excretion of morphine-glucuronides [0.03%]
多药耐药蛋白2和3为吗啡葡萄糖醛酸苷肝排泄提供替代途径
Koen van de Wetering,Noam Zelcer,Annemieke Kuil et al.
Koen van de Wetering et al.
Glucuronidation is a major hepatic detoxification pathway for endogenous and exogenous compounds, resulting in the intracellular formation of polar metabolites that require specialized transporters for elimination. Multidrug resistance prot...
A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor [0.03%]
一种新颖的多价配体可连接M2毒蕈碱受体的变构和正构结合位点
Tod Steinfeld,Mathai Mammen,Jacqueline A M Smith et al.
Tod Steinfeld et al.
THRX-160209 is a potent antagonist at the M(2) muscarinic acetylcholine (ACh) receptor subtype that was designed using a multivalent strategy, simultaneously targeting the orthosteric site and a nearby site known to bind allosteric ligands....