A novel multivalent ligand that bridges the allosteric and orthosteric binding sites of the M2 muscarinic receptor
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THRX-160209 is a potent antagonist at the M(2) muscarinic acetylcholine (ACh) receptor subtype that was designed using a multivalent strategy, simultaneously targeting the orthosteric site and a nearby site known to bind allosteric ligands. In this report, we ... ...
