Interleukin-6 alters the cellular responsiveness to clopidogrel, irinotecan, and oseltamivir by suppressing the expression of carboxylesterases HCE1 and HCE2 [0.03%]
白细胞介素-6通过抑制羧酸酯酶HCE1和HCE2的表达来改变氯吡格雷、伊立替康和奥司他韦的细胞反应性
Jian Yang,Deshi Shi,Dongfang Yang et al.
Jian Yang et al.
Carboxylesterases constitute a class of enzymes that play important roles in the hydrolytic metabolism of drugs and other xenobiotics. Patients with liver conditions such as cirrhosis show increased secretion of proinflammatory cytokines [e...
Comparative Study
Molecular pharmacology. 2007 Sep;72(3):686-94. DOI:10.1124/mol.107.036889 2007
The aryl hydrocarbon receptor sans xenobiotics: endogenous function in genetic model systems [0.03%]
无外源毒物的芳香烃受体：遗传模型系统中的内源功能
Brian J McMillan,Christopher A Bradfield
Brian J McMillan
For more than 30 years, the aryl hydrocarbon receptor [Ah receptor (AHR)] has been extensively scrutinized as the cellular receptor for numerous environmental contaminants, including polychlorinated dioxins, dibenzofurans, and biphenyls. Re...
Apoptotic action of peroxisome proliferator-activated receptor-gamma activation in human non small-cell lung cancer is mediated via proline oxidase-induced reactive oxygen species formation [0.03%]
激活人非小细胞肺癌中的凋亡作用通过脯氨酸氧化酶诱导的活性氧形成介导PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA
Ki Young Kim,Jin Hee Ahn,Hyae Gyeong Cheon
Ki Young Kim
Peroxisome proliferator-activated receptor (PPAR)-gamma ligands have been shown to inhibit human lung cancers by inducing apoptosis and differentiation. In the present study, we elucidated the apoptotic mechanism of PPARgamma activation in ...
A selective positive allosteric modulator of metabotropic glutamate receptor subtype 2 blocks a hallucinogenic drug model of psychosis [0.03%]
一种选择性激活元导联谷氨酸受体亚型的正变构调节剂可以阻断致幻药物所致精神病模型的作用
Michael A Benneyworth,Zixiu Xiang,Randy L Smith et al.
Michael A Benneyworth et al.
Recent clinical studies reveal that selective agonists of group II metabotropic glutamate (mGlu) receptors have robust efficacy in treating positive and negative symptoms in patients with schizophrenia. Group II mGlu receptor agonists also ...
Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors [0.03%]
M2型胆碱能受体变构激动剂的作用方式研究
Lauren T May,Vimesh A Avlani,Christopher J Langmead et al.
Lauren T May et al.
The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues (172)EDGE(175), Tyr(177), and Thr(423). However, the contribution of these residues to actions ...
Mariusz W Szkudlinski
Mariusz W Szkudlinski
Because gonadotropin-releasing hormone (GnRH) analogs constitute an important class of therapeutics for various reproductive and hormone-dependent disorders, many novel compounds have been discovered and studied. Several orally active nonpe...
Brain-derived neurotrophic factor: linking fear learning to memory consolidation [0.03%]
脑源性神经营养因子：连接恐惧学习与记忆巩固
Marie-H Monfils,Kiriana K Cowansage,Joseph E LeDoux
Marie-H Monfils
Brain-derived neurotrophic factor (BDNF), a member of the neurotrophin family, plays an important role in synaptic plasticity. In this issue of Molecular Pharmacology, Ou and Gean (p. 350) thoroughly describe the molecular cascade by which ...
Critical role for sphingosine kinase-1 in regulating survival of neuroblastoma cells exposed to amyloid-beta peptide [0.03%]
鞘氨醇激酶-1在调节暴露于β淀粉样蛋白肽的神经母细胞瘤细胞存活中的关键作用
Anne Gomez-Brouchet,Dimitri Pchejetski,Leyre Brizuela et al.
Anne Gomez-Brouchet et al.
We examined the role of sphingosine kinase-1 (SphK1), a critical regulator of the ceramide/sphingosine 1-phosphate (S1P) biostat, in the regulation of death and survival of SH-SY5Y neuroblastoma cells in response to amyloid beta (Abeta) pep...
Desensitization of the dopamine D1 and D2 receptor hetero-oligomer mediated calcium signal by agonist occupancy of either receptor [0.03%]
多巴胺D1/D2受体异二聚体介导的钙信号脱敏需要任何一种受体被激动剂占据
Christopher H So,Vaneeta Verma,Brian F O&#x;Dowd et al.
Christopher H So et al.
When dopamine D1 and D2 receptors were coactivated in D1-D2 receptor hetero-oligomeric complexes, a novel phospholipase C-mediated calcium signal was generated. In this report, desensitization of this Gq/11-mediated calcium signal was demon...
Inhibition of hypoxia-induced increase of blood-brain barrier permeability by YC-1 through the antagonism of HIF-1alpha accumulation and VEGF expression [0.03%]
抑制YC-1引起的低氧诱导的血脑屏障通透性的增加通过HIF-1α积累和VEGF表达的拮抗作用
Wei-Lan Yeh,Dah-Yuu Lu,Chun-Jung Lin et al.
Wei-Lan Yeh et al.
Cerebral microvascular endothelial cells form the anatomical basis of the blood-brain barrier (BBB), and the tight junctions of the BBB are critical for maintaining brain homeostasis and low permeability. Ischemia/reperfusion is known to da...