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Structure-function studies of allosteric agonism at M2 muscarinic acetylcholine receptors

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The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues (172)EDGE(175), Tyr(177), and Thr(423). However, the contribution of these residues to actions of allosteric agonis... ...