Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata [0.03%]
局麻药和钙对墨鱼电鳐烟碱受体蛋白与胆碱类配基相互作用的影响
J B Cohen,M Weber,J P Changeux
J B Cohen
Studies are presented of the interaction in a physiological ionic environment of aromatic amine local anesthetics (prilocaine, lidocaine, and dimethisoquin) and Ca++ with receptor-rich membrane fragments isolated from Torpedo electric organ...
Parawixin1: a spider toxin opening new avenues for glutamate transporter pharmacology [0.03%]
新型蛛毒素Parawixin1：研究谷氨酸转运蛋白药物的有力工具
Delany Torres-Salazar,Christoph Fahlke
Delany Torres-Salazar
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system. After release from glutamatergic nerve terminals, glial and neuronal glutamate transporters remove glutamate from the synaptic cleft to terminate sy...
Activation of nuclear factor (erythroid-2 like) factor 2 by toxic bile acids provokes adaptive defense responses to enhance cell survival at the emergence of oxidative stress [0.03%]
毒性的胆汁酸通过激活核因子(NrF-2相关因子2)诱导适应性防御反应以增强细胞在氧化应激条件下生存能力激发作用
Kah Poh Tan,Mingdong Yang,Shinya Ito
Kah Poh Tan
Oxidative stress, causing necrotic and apoptotic cell death, is associated with bile acid toxicity. Using liver (HepG2, Hepa1c1c7, and primary human hepatocytes) and intestinal (C2bbe1, a Caco-2 subclone) cells, we demonstrated that toxic b...
Evidence for an aryl hydrocarbon receptor-mediated cytochrome p450 autoregulatory pathway [0.03%]
芳族烃受体介导的细胞色素P450自主调节通路的证据
Christopher R Chiaro,Rushang D Patel,Craig B Marcus et al.
Christopher R Chiaro et al.
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor responsible for mediating the cellular response to the toxic compound 2,3,7,8,-tetrachlorodibenzo-p-dioxin. An essential role for the AhR in cellular biology has...
Mammalian skeletal muscle voltage-gated sodium channels are affected by scorpion depressant "insect-selective" toxins when preconditioned [0.03%]
预处理的蝎子抑制毒素可影响哺乳动物骨骼肌电压门控钠通道
Lior Cohen,Yael Troub,Michael Turkov et al.
Lior Cohen et al.
Among scorpion beta- and alpha-toxins that modify the activation and inactivation of voltage-gated sodium channels (Na(v)s), depressant beta-toxins have traditionally been classified as anti-insect selective on the basis of toxicity assays ...
Ligand-directed signaling at the beta3-adrenoceptor produced by 3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate (SR59230A) relative to receptor agonists [0.03%]
相对于受体激动剂的β3-肾上腺素能受体配体导向信号转导：3-(2-乙基苯氧基)-1-[(-1，S)-1，2,3,4-四氢萘-1-亚氨基]-2S-2-丙醇草酸盐(SR59230A)的作用
Masaaki Sato,Takahiro Horinouchi,Dana S Hutchinson et al.
Masaaki Sato et al.
This study examines signaling pathways activated by the mouse beta(3)-adrenoceptor (AR) expressed in Chinese hamster ovary cells at high (CHObeta(3)H) or low (CHObeta(3)L) levels. Functional responses included extracellular acidification ra...
Martin C Michel,Astrid E Alewijnse
Martin C Michel
In contrast to earlier concepts, it seems that distinct ligands acting on the same receptor may elicit qualitative different response patterns, a phenomenon given many names, including "functional selectivity," "agonist-directed trafficking...
The neurosteroids dehydroepiandrosterone sulfate and pregnenolone sulfate inhibit the UNC-49 GABA receptor through a common set of residues [0.03%]
脱氢表雄酮硫酸盐和孕烯醇龙硫酸盐通过共同的一组残基抑制UNC-49型GABA受体
Vernon Twede,Anthony L Tartaglia,Douglas F Covey et al.
Vernon Twede et al.
Neurosteroids are endogenous neuromodulators that bind and allosterically regulate GABA(A) receptors. Residues were recently identified in the first transmembrane domain (M1) of GABA(A) receptor subunits that are important for neurosteroid ...
Inhibition of the Na+/dicarboxylate cotransporter by anthranilic acid derivatives [0.03%]
氨基苯甲酸衍生物抑制Na+/二羧基cotransporter
Ana M Pajor,Kathleen M Randolph
Ana M Pajor
The Na(+)/dicarboxylate cotransporter NaDC1 absorbs citric acid cycle intermediates from the lumen of the small intestine and kidney proximal tubule. No effective inhibitor has been identified yet, although previous studies showed that the ...
Dimerization region of soluble guanylate cyclase characterized by bimolecular fluorescence complementation in vivo [0.03%]
用于体内研究可溶性鸟苷酸环化酶二聚作用区的双分子荧光补体技术
Christiane Rothkegel,Peter M Schmidt,Derek-John Atkins et al.
Christiane Rothkegel et al.
The ubiquitously expressed nitric oxide (NO) receptor soluble guanylate cyclase (sGC) plays a key role in signal transduction. Binding of NO to the N-terminal prosthetic heme moiety of sGC results in approximately 200-fold activation of the...