mRNA Targeting, Transport and Local Translation in Eukaryotic Cells: From the Classical View to a Diversity of New Concepts [0.03%]
真核细胞中的信使RNA靶向、运输及局部翻译：从经典观点到多种新概念
Kseniya A Lashkevich,Sergey E Dmitriev
Kseniya A Lashkevich
Spatial organization of protein biosynthesis in the eukaryotic cell has been studied for more than fifty years, thus many facts have already been included in textbooks. According to the classical view, mRNA transcripts encoding secreted and...
A A Kuznetsova,A A Gavrilova,D S Novopashina et al.
A A Kuznetsova et al.
Human apurinic/apyrimidinic endonuclease 1 (APE1) participates in the DNA repair system. It is believed that the main biological function of APE1 is Mg2+-dependent hydrolysis of AP-sites in DNA. On the base of structural data, kinetic studi...
The Effect of I155T, K156Q, K156E and N186K Mutations in Hemagglutinin on the Virulence and Reproduction of Influenza A/H5N1 Viruses [0.03%]
血凝素(I155T、K156Q、K156E和N186K)突变对高致病性H5N1禽流感病毒毒力及复制的影响研究
T A Timofeeva,G K Sadykova,N F Lomakina et al.
T A Timofeeva et al.
The continued circulation of influenza A virus subtype H5 may cause the emergence of new potential pandemic virus variants, which can be transmitted from person to person. The occurrence of such variants is mainly related to mutations in he...
The Challenges of Vaccine Development against Betacoronaviruses: Antibody Dependent Enhancement and Sendai Virus as a Possible Vaccine Vector [0.03%]
对抗Betacoronaviruses疫苗开发的挑战：抗体依赖增强和腮腺炎病毒作为一种可能的疫苗载体
T A Zaichuk,Y D Nechipurenko,A A Adzhubey et al.
T A Zaichuk et al.
To design an effective and safe vaccine against betacoronaviruses, it is necessary to use their evolutionarily conservative antigenic determinants that will elicit the combination of strong humoral and cell-mediated immune responses. Target...
A Recombinant Rotavirus Antigen Based on the Coat Protein of Alternanthera Mosaic Virus [0.03%]
基于Alternanthera mosaic virus包衣蛋白的轮状病毒重组抗原
E M Ryabchevskaya,E A Evtushenko,M V Arkhipenko et al.
E M Ryabchevskaya et al.
Thanks to their strong immunostimulating properties and safety for humans, plant viruses represent an appropriate basis for the design of novel vaccines. The coat protein of Alternanthera mosaic virus can form virus-like particles that are ...
Conformational Fingerprinting Using Monoclonal Antibodies (on the Example of Angiotensin I-Converting Enzyme-ACE) [0.03%]
基于单克隆抗体的构象指纹鉴定法（以血管紧张素转换酶ACE为例）
S M Danilov
S M Danilov
During the past 30 years my laboratory has generated 40+ monoclonal antibodies (mAbs) directed to structural and conformational epitopes on human ACE as well as ACE from rats, mice and other species. These mAbs were successfully used for de...
B V Syomin,Y V Ilyin
B V Syomin
The paper discusses the techniques which are currently implemented for vaccine production based on virus-like particles (VLPs). The factors which determine the characteristics of VLP monomers assembly are provided in detail. Analysis of the...
A A Lushova,M G Biazrova,A G Prilipov et al.
A A Lushova et al.
Monoclonal antibodies have found wide applications in the treatment of cancer, as well as of autoimmune, infectious, and other diseases. Several dozen new antibodies are currently undergoing different stages of clinical trials, and some of ...
V M Blinov,V V Zverev,G S Krasnov et al.
V M Blinov et al.
Relationships between viruses and their human host are traditionally described from the point of view taking into consideration hosts as victims of viral aggression, which results in infectious diseases. However, these relations are in fact...
I G Laptev,A Ya Golovina,P V Sergiev et al.
I G Laptev et al.
Transcriptome-wide mapping of posttranscriptional modifications in eukaryotic RNA revealed tens of thousands of modification sites. Modified nucleotides include 6-methyladenosine, 5-methylcytidine, pseudouridine, inosine, etc. Many modifica...