Primary and Secondary micro-RNA Modulation the Extrinsic Pathway of Apoptosis in Hepatocellular Carcinoma [0.03%]
原发和继发性微小RNA调节肝细胞癌中外在凋亡途径
T M Khlebodarova,P S Demenkov,T V Ivanisenko et al.
T M Khlebodarova et al.
Abstract-One of the most common malignant liver diseases is hepatocellular carcinoma, which has a high recurrence rate and a low five-year survival rate. It is very heterogeneous both in structure and between patients, which complicates the...
I V Astrakhantseva,V G Krut&#x;,S A Chuvpilo et al.
I V Astrakhantseva et al.
This short report summarizes the results of recent immunological studies performed at new Sirius University of Science and Technology. The report focuses on studying the features of the immune response to vaccination and revaccination again...
Increased Frequencies of the ‒174G and ‒572C IL6 Alleles in Populations of Indigenous Peoples of Siberia Compared to Russians [0.03%]
与俄罗斯人相比西伯利亚土著人群中IL6-174G和-572C等位基因频率增加
L E Tabikhanova,L P Osipova,T V Churkina et al.
L E Tabikhanova et al.
Abstract-The study of immune response and inflammation gene polymorphisms in a genogeographic context is relevant in the study of human populations. Here, in the indigenous populations of Siberia the frequencies of polymorphic variants ‒17...
L A Oleinik,P G Madonov,M B Pykhtina
L A Oleinik
This study provides an overview of scientific results on the feasibility of using type III interferons against SARS-CoV-2. We have analyzed data obtained from the PubMed electronic database for the period 2020‒2022. The results of our own ...
M I Airapetov,S O Eresko,P D Ignatova et al.
M I Airapetov et al.
The study of the role of cytokines in various pathological conditions of the body is a topical area in modern biomedicine. Understanding the physiological roles played by cytokines will aid in finding applications for them as pharmacologica...
High Heterogeneity of Virus-Neutralizing and RBD-Binding Activities of COVID-19 Convalescent Sera [0.03%]
新冠恢复期血清病毒中和与RBD结合活性的高度异质性
E A Astakhova,M G Byazrova,G M Yusubalieva et al.
E A Astakhova et al.
The parameters of the humoral response are an important immunological characteristic of donors who recovered from COVID-19 and vaccinated individuals. Analysis of the level of virus-binding antibodies has become widespread. The most accurat...
Structural Elements of DNA and RNA Eukaryotic Expression Vectors for In Vitro and In Vivo Genome Editor Delivery [0.03%]
DNA和RNA真核表达载体的结构元件用于体内外基因组编辑器的传递
A A Zagoskin,M V Zakharova,M O Nagornykh
A A Zagoskin
Gene editing with programmable nucleases opens new perspectives in important practice areas, such as healthcare and agriculture. The most challenging problem for the safe and effective therapeutic use of gene editing technologies is the pro...
Generation of SARS-CoV-2 Mouse Model by Transient Expression of the Human ACE2 Gene Mediated by Intranasal Administration of AAV-hACE2 [0.03%]
通过鼻内给药AAV-hACE2瞬时表达人ACE2基因产生新型冠状病毒肺炎小鼠模型
D V Glazkova,E V Bogoslovskaya,F A Urusov et al.
D V Glazkova et al.
One of the most important steps in the development of drugs and vaccines against a new coronavirus infection is their testing on a relevant animal model. The laboratory mouse, with well-studied immunology, is the preferred mammalian model i...
P O Vorobyev,F E Babaeva,A V Panova et al.
P O Vorobyev et al.
Cancer is a leading causes of death. Despite significant success in the treatment of lymphatic system tumors, the problems of relapse, drug resistance and effectiveness of therapy remain relevant. Oncolytic viruses are able to replicate in ...
M V Golikov,V T Valuev-Elliston,O A Smirnova et al.
M V Golikov et al.
Changes in cell metabolism accompany the development of a wide spectrum of pathologies including cancer, autoimmune, and inflammatory diseases. Therefore, usage of inhibitors of metabolic enzymes are considered a promising strategy for the ...