G R Vinogradskaya,A V Ivanov,A A Kushch
G R Vinogradskaya
Human cytomegalovirus (HCMV) DNA and proteins are often detected in malignant tumors, warranting studies of the role that HCMV plays in carcinogenesis and tumor progression. HCMV proteins were shown to regulate the key processes involved in...
D V Avdoshina,A S Kondrashova,M G Belikova et al.
D V Avdoshina et al.
Viruses are now recognized as bona fide etiologic factors of human cancer. Carcinogenic viruses include Epstein- Barr virus (EBV), high-risk human papillomaviruses (HPVs), hepatitis B virus (HBV), hepatitis C virus (HCV), human T-cell leuke...
E S Pshennikova,A S Voronina
E S Pshennikova
Many cells are capable of maintaining viability in a non-dividing state with minimal metabolism under unfavorable conditions. These are germ cells, adult stem cells, and microorganisms. Unfortunately, a resting state, or dormancy, is possib...
Enhancement of the Bactericidal Effect of Antibiotics by Inhibition of Enzymes Involved in Production of Hydrogen Sulfide in Bacteria [0.03%]
通过抑制细菌产硫化氢相关酶以增强抗生素的杀菌作用
T A Seregina,K V Lobanov,R S Shakulov et al.
T A Seregina et al.
Counteraction of the origin and distribution of multidrug-resistant pathogens responsible for intra-hospital infections is a worldwide issue in medicine. In this brief review, we discuss the results of our recent investigations, which argue...
E V Kropocheva,L A Lisitskaya,A A Agapov et al.
E V Kropocheva et al.
Programmable nucleases are the most important tool for manipulating the genes and genomes of both prokaryotes and eukaryotes. Since the end of the 20th century, many approaches were developed for specific modification of the genome. The rev...
New Analogues of Uridine as Possible Anti-Viral Agents Specific to SARS-CoV-2 [0.03%]
一些具有抗SARS-CoV-2病毒活性的尿苷类似物
A A Maslova,E C Matyugina,E Yu Shustova et al.
A A Maslova et al.
The development of specific drugs against SARS-CoV-2 infection is a major challenge facing global science and healthcare. Despite numerous attempts, there are still no truly effective drugs. Currently, the main approach in the creation of d...
Increased LAMP1 Expression Enhances SARS-CoV-1 and SARS-CoV-2 Production in Vero-Derived Transgenic Cell Lines [0.03%]
LAMP1表达增强可提升转基因VERO细胞系SARS-COV-1和SARS-CoV-2的产生能力
A A Dolskiy,I V Grishchenko,S A Bodnev et al.
A A Dolskiy et al.
Coronaviridae is a family of single-stranded RNA (ssRNA) viruses that can cause diseases with high mortality rates. SARS-CoV-1 and MERS-CoV appeared in 2002‒2003 and 2012, respectively. A novel coronavirus, SARS-CoV-2, emerged in 2019 in W...
MicroRNAs as the Potential Regulators of SARS-CoV-2 Infection and Modifiers of the COVID-19 Clinical Features [0.03%]
微小核糖核酸可能调控SARS-CoV-2感染及COVID-19临床特征的表型变异
A N Kucher,Iu A Koroleva,A A Zarubin et al.
A N Kucher et al.
The pandemic of coronavirus disease 2019 (COVID-19) warrants the identification of factors that may determine both risk and severity of infection. The factors include microRNAs that have a wide regulatory potential and hence are particularl...
Adaptation of Microarray Assay for Serum Amyloid a Analysis in Human Serum [0.03%]
人血清中微量阵列测定术检测原纤维蛋白-A的改良法
O V Smoldovskaya,S A Voloshin,A A Novikov et al.
O V Smoldovskaya et al.
Serum amyloid A is an inflammatory biomarker whose concentration changes during infectious and inflammatory diseases. SAA's tendency for aggregation and complex formation makes it difficult to determine its concentration in samples, especia...
Analogs of S-Adenosyl- L-Methionine in Studies of Methyltransferases [0.03%]
S-腺苷-L-甲硫氨酸类似物在甲基转移酶研究中的应用
A Yu Rudenko,S S Mariasina,P V Sergiev et al.
A Yu Rudenko et al.
Methyltransferases (MTases) play an important role in the functioning of living systems, catalyzing the methylation reactions of DNA, RNA, proteins, and small molecules, including endogenous compounds and drugs. Many human diseases are asso...