Synthesis and chemical reactivity of a 6-Me-3,2-hydroxypyridinone dithiazolide with primary amines: a route to new hexadentate chelators for hard metal(III) ions [0.03%]
合成并研究了6-Me-3,2-羟基吡啶N，O二羧酸双硫代酯与伯胺的化学反应：一种合成螯合六元环的新方法以用于硬金属离子
Sylvie L Pailloux,Sean Nguyen,Stephanie Zhou et al.
Sylvie L Pailloux et al.
A hydroxypyridinone building block, bifunctionalized with thiazoline, has been prepared from orthogonally protected 2-(3-(benzyloxy)-4-(ethoxycarbonyl)-6-methyl-2-oxopyridin-1(2H)-yl) acetic acid. The reactivity of the dithiazolide has been...
The Thermal Instability of 2,4 and 2,6- N-Alkylamino Disubstituted and 2- N-Alkylamino Substituted Nitrobenzenes in Weakly Alkaline Solution: sec-Amino Effect [0.03%]
弱碱性介质中2，4和2，6-N烷氨基双取代及2- N烷基氨基单取代硝基苯的热不稳定性—间位效应
Christopher Walczak,Thomas J Payne,Colin B Wade et al.
Christopher Walczak et al.
We report herein the preparation of two families of secondary amines by the reactions of two equivalents of monoamines with either 2,4 or 2,6-difluoronitrobenzenes in N,N-dimethylacetamide in the presence of anhydrous potassium carbonate, a...
Dithiolopyranthione Synthesis, Spectroscopy and an Unusual Reactivity with DDQ [0.03%]
二硫环噻唑并硫酮的合成、光谱及与DDQ反常反应性
Igor V Pimkov,Archana Nigam,Kiran Venna et al.
Igor V Pimkov et al.
The bicyclic pyran thiolone tetrahydro-3αH-[1,3]dithiolo[4,5-β]pyran-2-thione (3a) engages in a highly unusual fragmentation in the presence of DDQ. The pyran thiolone, 3a, was synthesized by chlorination of 3,4-dihydro-2H-pyran (1), foll...
Bichalcophenes: A Concise Synthesis of Formyl Ester- and Cyano Ester-Substituted Bithiophenes, Bifurans, and Furanothiophenes [0.03%]
二醛酯和氰基酯取代的双噻吩、双呋喃和噻吩并呋喃类化合物的简洁合成
Abdelbasset A Farahat,Arvind Kumar,Alaa El-Din M Barghash et al.
Abdelbasset A Farahat et al.
Syntheses of new formyl ester- and cyano ester-substituted bithiophenes, bifurans, and furanothiophenes in good yield are described. The key synthetic step uses Stille coupling of appropriately substituted bromo 5-ring heterocycles with sta...
Synthesis of 2-(N-Benzylpyrrolyl)-benzimidazoles Using Polyphosphoric Acid Prompted Cyclocondensation [0.03%]
聚磷酸促进环化缩合反应合成2-(N-苯基吡咯基)取代的苯并咪唑类化合物
Bereket Mochona,Laine Le,Madhavi Gangapuram et al.
Bereket Mochona et al.
Synthesis of a series of 2-substituted benzimidazoles was carried out for screening anti-inflammatory activities. 2-(N-benzylpyrrolyl)-benzimidazoles 9a-k were synthesized from N-benzyl-2-pyrrole carboxylic acids 8a-d and 4-substituted-1,2-...
Synthesis of Novel Functionalized 4-Aza-2,3-Didehydropodophyllotoxin Derivatives with Potential Antitumor Activity [0.03%]
具有抗肿瘤活性的新型功能化4-氮杂-2,3-二脱氢 podophyllotoxin 衍生物的合成
Ajay Kumar,Antonio E Alegria
Ajay Kumar
Novel arylamino alcohols were synthesized and these alcohols were used to prepare 12 novel N-(2-hydroxy-ethyl)-2,3-didehydroazapodophyllotoxins, in one step, by simple reflux in ethanol. Isolated yields in the range of 50-70% were obtained.
Synthesis of 1-(Substituted Phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydropyridine-5-carboxylic acid diethylamides as Potential Anti-inflammatory Agents [0.03%]
合成具有潜在抗炎活性的1-（取代苯甲酰/磺酰氨基）-1，2，3，6-四氢吡啶并[4,5-b]吲哚-5-甲酸二乙胺类化合物
Madhavi Gangapuram,Kinfe K Redda
Madhavi Gangapuram
Fifteen novel 1-(substituted phenylcarbonyl/sulfonylamino)-1,2,3,6-tetrahydro- pyridine-5-carboxylic acid diethylamide (7, 15) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding 1-(substituted phen...
Synthesis of Substituted N-[4(5-Methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-yl]benzamide/benzene Sulfonamides as Anti-Inflammatory and Anti-Cancer Agents [0.03%]
合成取代的N-[4-(5-甲基/苯基-1,3,4-噁二唑-2-基)-3,6-二氢吡啶-1(2H)-基]苯甲酰胺/苯磺酰胺类抗炎和抗癌剂
Madhavi Gangapuram,Kinfe K Redda
Madhavi Gangapuram
Fourteen novel substituted N-[4(5-methyl/phenyl-1,3,4-oxadiazol-2-yl)-3,6-dihydropyridin-1(2H)-y1] benzamide/benzene sulfonamides (11a-n) were synthesized in fair to good yields via sodium borohydride reduction of the corresponding substitu...
A New and Efficient Approach to the Synthesis of Nicotine and Anabasine Analogues [0.03%]
尼古丁和安巴辛类似物合成的新方法及应用研究进展
Kun Huang,Margarita Ortiz-Marciales,Melvin De Jesús et al.
Kun Huang et al.
A straightforward and practical approach was established for the synthesis of nicotine and anabasine analogues by the cyclization of mesylated 1-(3-pyridinyl)-1,4, and 1,5-diol derivatives to form the pyrrolidino or piperidino fragments. Ni...
R S Vardanyan,V J Hruby,G G Danagulyan et al.
R S Vardanyan et al.
This communication reports on the investigation of a new recyclization conversion of a pyrimidine ring, which can be referred to as C-C recyclization. In this reaction the nucleophile cleaves the pyrimidine ring at the N(3)-C(4) bond, and f...