Microwave-accelerated conjugate addition of 2-arylindoles to substituted β-nitrostyrenes in the presence of ammonium trifluoroacetate: an efficient approach for the synthesis of a novel class of CB1 cannabinoid receptor allosteric modulators [0.03%]
在三氟乙酸铵存在下微波加速2-芳基吲哚与取代β-硝基苯乙烯的共轭加成反应：合成一类新型CB1大麻素受体变构调节剂的有效方法
Pushkar M Kulkarni,Ameya Ranade,Sumanta Garai et al.
Pushkar M Kulkarni et al.
2-Arylindoles, in general exhibit reduced reactivity towards the conjugate addition to substituted nitrostyrenes, when compared to indoles. We report here an efficient, expeditious and high-yielding conjugate addition of 2-arylindoles to su...
Structure-Activity Relationship Investigations Probing the Cytotoxicity of 9-Aminoacridines Derivatives with PC3 and A549 [0.03%]
探查9-氨基吖啶衍生物与PC3和A549细胞毒性的结构活性关系研究
Grace S Blount,Austin Seymour,Dylan Williams et al.
Grace S Blount et al.
9-Aminoacridine structures hold much potential for accessing small molecule therapeutics. This core is present in a range of pharmaceuticals for the treatment of ailments such as malaria, inflammation, viral and bacterial infections, and ca...
Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) [0.03%]
羟氯喹和瑞德西韦对严重急性呼吸系统综合症冠状病毒2型(SARS-CoV-2)的影响概述
Arup K Kabi,Maynak Pal,Raghuram Gujjarappa et al.
Arup K Kabi et al.
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused the ongoing pandemic named COVID-19 which causes a serious emergency on public health hazards of international concern. In the face of a critical medical emergenc...
Cyclizations and fragmentations in the alkylation of 6-chloro-5-hydroxy-4-aminopyrimidines with aminoalkyl chlorides [0.03%]
6-氯-5-羟基-4-氨基嘌呤与氨基烷基氯的烷基化中的环化和碎片化反应
Edwige M H Picazo,Amy B Heptinstall,David M Wilson et al.
Edwige M H Picazo et al.
Substituted aminopyrimidines are an important class of compounds, in part because they frequently show biological activity. Facile synthesis of polysubstituted aminopyrimidines is highly desirable for the synthesis of screening libraries. W...
First synthesis of thiazepino[3,4-a]isoquinolines, a facile new synthetic route to diazepino[3,4-a]isoquinolines and assessment of their dopamine and σ receptor affinities [0.03%]
thiazepino[3,4-a]isoquinoline的首次合成，一种新的简便的diazepino[3,4-a]isoquinoline的合成路线及其多巴胺和σ受体亲合力评估
Pierpaolo Cordone,Hari Krishna Namballa,Wayne Wesley Harding
Pierpaolo Cordone
Heterocycles that bear the novel 5,6,14,14a-tetrahydro-8H-benzo[6,7][1,4] thiazepino[3,4-a]isoquinoline and the 5,6,14,14a-tetrahydro-8H-13l2-benzo [6,7][1,4]diazepino[3,4-a]isoquinoline frameworks were synthesized in a facile manner. These...
Synthesis of antimicrobial azoloazines and molecular docking for inhibiting COVID-19 [0.03%]
用于抑制COVID-19的抗菌唑挫嗪的合成及分子对接研究
Zeinab A Muhammad,Thoraya A Farghaly,Ismail Althagafi et al.
Zeinab A Muhammad et al.
Diverse new azoloazines were synthesized from the reaction of fluorinated hydrazonoyl chlorides with heterocyclic thiones, 1,8-diaminonaphthalene, ketene aminal derivatives, and 4-amino-5-triflouromethyl-1,2,4-triazole-2-thiol. The mechanis...
Development of an efficient, one-pot, multicomponent protocol for synthesis of 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives [0.03%]
一种合成8-羟基-4-苯基-1,2-二氢喹啉衍生物的高效、一锅多组分反应体系的研究与发展
Rukhsana Tabassum,Muhammad Ashfaq,Hiroyuki Oku
Rukhsana Tabassum
A one-pot quick and efficient multicomponent reaction has been developed for the synthesis of a new series of functionalized 8-hydroxy-4-phenyl-1,2-dihydroquinoline derivatives using 30 mol% ammonium acetate in ethanol as solvent. This econ...
Ganarajan Sivasubramanian,Veembil Ramachandran Parameswaran
Ganarajan Sivasubramanian
chemical structure image Environmentally benign oxidation methods satisfy the postulates of green chemistry. Heterocyclic Noxides have applications in synthetic organic chemistry, chemotherapy and agrochemicals. Synthesis of Noxides using g...
Synthesis and Investigation of Mixed μ-Opioid and δ-Opioid Agonists as Possible Bivalent Ligands for Treatment of Pain [0.03%]
μ-型和δ-型阿片受体激动剂的合成与研究作为可能的双价配体用于止痛治疗
Ruben S Vardanyan,James P Cain,Saghar Mowlazadeh Haghighi et al.
Ruben S Vardanyan et al.
Several studies have suggested functional association between μ-opioid and δ-opioid receptors and showed that μ-activity could be modulated by δ-ligands. The general conclusion is that agonists for the δ-receptor can enhance the analge...
Application of Suzuki-Miyaura and Buchwald-Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine [0.03%]
铃木-宫浦和布克瓦尔德-哈特维格交叉偶联反应在合成抗肿瘤剂替拉扎明类似物中的苯并三氮唑氧化物的应用研究论文
Ujjal Sarkar,Roman Hillebrand,Kevin M Johnson et al.
Ujjal Sarkar et al.
Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides th...