Absolute Configuration and an Improved Automated cGMP Production of a Clinically Promising Radiotracer for Imaging VAChT [0.03%]
绝对构型和改进的自动化cGMP生产一种有前景的临床VAChT成像放射示踪剂方法
Yanbo Yu,Anil Kumar Soda,Christopher Bognar et al.
Yanbo Yu et al.
The vesicular acetylcholine transporter (VAChT), primarily located in presynaptic cholinergic nerve terminals, serves as a key target in neuroimaging studies and neuropathological assessments to quantify cholinergic neuron decline. [18F]VAT...
Enantioselective isothiourea-catalysed α-fluorination of C1-ammonium enolates generated from arylesters [0.03%]
由芳基酯生成C1-铵烯醇盐的对映选择性异硫脲催化α-氟化反应
Nicole Stanek,Lotte Stockhammer,Anja Moser et al.
Nicole Stanek et al.
We herein report the chiral isothiourea-catalyzed α-fluorination of electron-deficient arylesters. This transformation proceeds via the in situ formation of chiral C1-ammonium enolates, which then undergo the α-fluorination with high leve...
Two F-18 radiochemistry methods to synthesize a promising transient receptor potential canonical 5 (TRPC5) radioligand [0.03%]
两种用于合成很有前景的瞬时受体电位香草素通道5放射配基的F-18放射化学方法
Yanbo Yu,Sandip B Jadhav,Zhimin Xing et al.
Yanbo Yu et al.
TRPC5 is a member of the mammalian transient receptor potential (TRP) channel superfamily and it has been implicated in various physiological and pathological mechanisms of neurological and psychiatric diseases. Fluorine-18 is one of the mo...
Targeted [Formula: see text] to detect amino acids in complex mixtures using NMR spectroscopy [0.03%]
靶向[公式见英文原题]检测复杂混合物中氨基酸的NMR光谱法
Keeton Montgomery,Aya Elhabashy,Guanglin Chen et al.
Keeton Montgomery et al.
Nuclear magnetic resonance spectroscopy of fluorine-19 nucleus ( F 19 -NMR) emerges as a powerful tool because of the high sensitivity due to its high natural abundance, broad spectral range, and the simplicity of a spin-half system. H...
Recent advances in the strategic incorporation of fluorine into new-generation taxoid anticancer agents [0.03%]
近年来氟元素战略性引入新一代紫杉烷类抗肿瘤药物的研究进展
Kalani Jayanetti,Kathryn Takemura,Hersh Bendale et al.
Kalani Jayanetti et al.
This account describes our recent progress on the strategic incorporation of fluorine and organofluorine moieties into new-generation taxoid anticancer agents for medicinal chemistry and chemical biology studies. In the case study 1, novel ...
Kinetic Mechanism of 2,3,3,3-Tetrafluoropropene (HFO-1234yf) Combustion [0.03%]
2,3,3,3-四氟丙烯(HFO-1234yf)燃烧的kinetic机制研究
V I Babushok,G T Linteris
V I Babushok
A kinetic model for 2,3,3,3-tetrafluoropropene (HFO-1234yf) high temperature oxidation and combustion is proposed. It is combined with the GRI-Mech-3.0 model, the previously developed model for 2-bromo-3,3,3-trifluoropropene (2-BTP), and th...
Adamantyl-ureas with pyrazoles substituted by fluoroalkanes as soluble epoxide hydrolase inhibitors [0.03%]
含氟代烷基取代吡唑的 adamantyl 脲类可溶性环氧合酶抑制剂
Vladimir V Burmistrov,Christophe Morisseau,Tatyana K Shkineva et al.
Vladimir V Burmistrov et al.
A series of soluble epoxide hydrolase (sEH) inhibitors containing halogenated pyrazoles was developed. Inhibition potency of the obtained compounds ranges from 0.8 to 27.5 nM. 1-Adamantyl-3-[(4,5-dichloro-1-methyl-1Н-pyrazol-3-yl)methyl]ur...
Transient Formation of Hemiketals from Pentafluoro- gem-diols in the Presence of Alcohols [0.03%]
醇存在下戊氟环二醇的半缩酮的瞬态形成
Baharul Islam,David A Colby
Baharul Islam
Pentafluoro-gem-diols have emerged as a source of reactive intermediates for synthesizing fluorinated molecules. When pentafluoro-gem-diols were exposed to alcohols as solvents, the formation of transient hemiketals was detected by 19F NMR....
Development of a single culture E. coli expression system for the enzymatic synthesis of fluorinated tyrosine and its incorporation into proteins [0.03%]
用于体内酶法合成氟代酪氨酸的表达体系构建及其在蛋白质中的遗传编码研究进展
Noelle M Olson,Jorden A Johnson,Kerstin E Peterson et al.
Noelle M Olson et al.
Current experiments that rely on biosynthetic metabolic protein labeling with 19F often require fluorinated amino acids, which in the case of 2- and 3-fluorotyrosine can be expensive. However, using these amino acids has provided valuable i...
Synthesis and applications of S-(trifluoromethyl)-2,8-bis(trifluoromethoxy)dibenzothiophenium triflate (Umemoto reagent IV) [0.03%]
用于合成三氟甲基化试剂Umemoto试剂IV的制备及其应用研究
Sagar R Mudshinge,Gerald B Hammond,Teruo Umemoto
Sagar R Mudshinge
A new, powerful, and easy-to-handle electrophilic trifluoromethylating agent, S-(trifluoromethyl)-2,8-bis(trifluoromethoxy)dibenzothiophenium triflate (Umemoto reagent IV), was developed. Due to the extraordinary electronic effect of triflu...