Listening to Brain Microcircuits for Interfacing With External World-Progress in Wireless Implantable Microelectronic Neuroengineering Devices: Experimental systems are described for electrical recording in the brain using multiple microelectrodes and short range implantable or wearable broadcasting units [0.03%]
聆听脑内微环路，实现与外部世界的交互：无线植入式微型电子神经工程设备的研究进展
Arto V Nurmikko,John P Donoghue,Leigh R Hochberg et al.
Arto V Nurmikko et al.
Acquiring neural signals at high spatial and temporal resolution directly from brain microcircuits and decoding their activity to interpret commands and/or prior planning activity, such as motion of an arm or a leg, is a prime goal of moder...
Designing Neural Networks in Culture: Experiments are described for controlled growth, of nerve cells taken from rats, in predesigned geometrical patterns on laboratory culture dishes [0.03%]
文化中的神经网络设计：在实验室培养皿上的预定几何图案上控制培养实验所用取自大鼠的神经细胞的增长和分布
Bruce C Wheeler,Gregory J Brewer
Bruce C Wheeler
Technology has advanced to where it is possible to design and grow-with predefined geometry and surprisingly good fidelity-living networks of neurons in culture dishes. Here we overview the elements of design, emphasizing the lithographic t...
Tzyy-Ping Jung,Scott Makeig,Martin J McKeown et al.
Tzyy-Ping Jung et al.
The analysis of electroencephalographic (EEG) and magnetoencephalographic (MEG) recordings is important both for basic brain research and for medical diagnosis and treatment. Independent component analysis (ICA) is an effective method for r...
The Neurobiological Basis of Cognition: Identification by Multi-Input, Multioutput Nonlinear Dynamic Modeling: A method is proposed for measuring and modeling human long-term memory formation by mathematical analysis and computer simulation of nerve-cell dynamics [0.03%]
认知的神经生物学基础：通过多输入、多输出非线性动态建模识别
Theodore W Berger,Dong Song,Rosa H M Chan et al.
Theodore W Berger et al.
The successful development of neural prostheses requires an understanding of the neurobiological bases of cognitive processes, i.e., how the collective activity of populations of neurons results in a higher level process not predictable bas...
Strategies and Tactics in Multiscale Modeling of Cell-to-Organ Systems [0.03%]
从细胞到器官系统的多尺度建模策略与方法研究进展
James B Bassingthwaighte,Howard Jay Chizeck,Les E Atlas
James B Bassingthwaighte
Modeling is essential to integrating knowledge of human physiology. Comprehensive self-consistent descriptions expressed in quantitative mathematical form define working hypotheses in testable and reproducible form, and though such models a...
A Alvin Barlian,Woo-Tae Park,Joseph R Mallon Jr et al.
A Alvin Barlian et al.
Piezoresistive sensors are among the earliest micromachined silicon devices. The need for smaller, less expensive, higher performance sensors helped drive early micromachining technology, a precursor to microsystems or microelectromechanica...
Jeanette P Schmidt,Scott L Delp,Michael A Sherman et al.
Jeanette P Schmidt et al.
Physics-based simulation is needed to understand the function of biological structures and can be applied across a wide range of scales, from molecules to organisms. Simbios (the National Center for Physics-Based Simulation of Biological St...
Computational Systems Bioinformatics and Bioimaging for Pathway Analysis and Drug Screening [0.03%]
pathway分析与药物筛选的计算系统生物信息学和生物影像学
Xiaobo Zhou,Stephen T C Wong
Xiaobo Zhou
The premise of today's drug development is that the mechanism of a disease is highly dependent upon underlying signaling and cellular pathways. Such pathways are often composed of complexes of physically interacting genes, proteins, or bioc...
Barjor Gimi,Arvind P Pathak,Ellen Ackerstaff et al.
Barjor Gimi et al.
Cancer is a complex disease exhibiting a host of phenotypic diversities. Noninvasive multinuclear magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI) provide an array of capabilities to characterize and understand several of t...
Therapeutic Robotics: A Technology Push: Stroke rehabilitation is being aided by robots that guide movement of shoulders and elbows, wrists, hands, arms and ankles to significantly improve recovery of patients [0.03%]
医疗机器人：技术推动：用于指导肩关节和肘关节、腕关节、手和臂以及踝关节的运动，有助于中风恢复，显著改善患者的康复效果
Hermano Igo Krebs,Neville Hogan
Hermano Igo Krebs
In this paper, we present a retrospective and chronological review of our efforts to revolutionize the way physical medicine is practiced by developing and deploying therapeutic robots. We present a sample of our clinical results with well ...