En Route to Enantioenriched Quaternary Stereocenters via Lewis Base/Palladium Cooperative Catalysis [0.03%]
手性Lewis碱/钯协同催化构建四官能团化立体中心研究进展
Maygan M McGuire,Andrew C Bach,Maren Pink et al.
Maygan M McGuire et al.
The prevalence of quaternary stereogenic centers in bioactive molecules coupled with innate challenges associated with their enantioselective preparation continues to provide powerful impetus for the development of catalytic asymmetric meth...
Design and Synthesis of Dialkylarylphosphine Urea Ligands and their Application in Palladium-Catalyzed Cross-Coupling Reactions [0.03%]
二烷基芳基膦脲配体的设计合成及在钯催化交叉偶联反应中的应用研究
Lupita S Aguirre,Levi T Litwiller,Alexis N Lugo et al.
Lupita S Aguirre et al.
We describe herein the design and synthesis of a new class of dialkylarylphosphine ligands incorporating a Lewis-basic urea subunit. The ligand synthesis consisted of six linear steps and was enabled by the discovery of a new N-to-N alkyl m...
Dynemicin A Derivatives as Potential Cancer Chemotherapeutics by Mutasynthesis [0.03%]
利用定向进化代谢工程开发抗肿瘤药物dynemicin A衍生物的研究
Paramita Pal,Jamie R Alley,Douglas R Cohen et al.
Paramita Pal et al.
The enediyne antitumor antibiotics have remarkable structures and exhibit potent DNA cleavage properties that have inspired continued interest as cancer therapeutics. Their complex structures and high reactivity, however, pose formidable ch...
Stereoselective Syntheses of Masked β-Amino Acid Containing Phthalides [0.03%]
含β-氨基酸的酞啶类化合物的立体选择性合成
Lorenzo Serusi,Paul Zebrowski,Johannes Schörgenhumer et al.
Lorenzo Serusi et al.
We herein report a protocol for the asymmetric aldol-initiated cascade addition of isoxazolidin-5-ones to ortho-cyanobenzaldehydes by using Takemoto's bifunctional organocatalyst. This approach allows for the synthesis of various novel β2,...
Hydroamination of Dihapto-Coordinated Benzene and Diene Complexes of Tungsten: Fundamental Studies and the Synthesis of γ-Lycorane [0.03%]
基于钨的苯和二烯配合物的氢胺化反应：基础研究与γ-天冬酰胺的合成
Katy B Wilson,Hannah S Nedzbala,Spenser R Simpson et al.
Katy B Wilson et al.
Reactions are described for complexes of the form WTp(NO)(PMe3)(η2-arene) and various amines, where the arene is benzene or benzene with an electron-withdrawing substituent (CF3, SO2Ph, SO2Me). The arene complex is first protonated to form...
The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor [0.03%]
HuR是 kinetically-privileged 亲电子剂传感器的mRNA结合蛋白
Jesse R Poganik,Alexandra K Van Hall-Beauvais,Marcus J C Long et al.
Jesse R Poganik et al.
The key mRNA-binding proteins HuR and AUF1 are reported stress sensors in mammals. Intrigued by recent reports of sensitivity of these proteins to the electrophilic lipid prostaglandin A2 and other redox signals, we here examined their sens...
Screening of copper and palladium-mediated reactions compatible with DNA-encoded chemical libraries [0.03%]
筛选出与DNA编码化合物文库兼容的铜和钯催化的反应
Nicholas Favalli,Gabriele Bassi,Tania Zanetti et al.
Nicholas Favalli et al.
The construction of DNA-encoded chemical libraries (DECLs) crucially relies on the availability of chemical reactions, which are DNA-compatible and which exhibit high conversion rates for a large number of diverse substrates. In this work, ...
Replacement of an Indole Scaffold Targeting Human 15-Lipoxygenase-1 Using Combinatorial Chemistry [0.03%]
基于组合化学的用于人类15-LOX-1的吲哚骨架靶向化合物的取代
Deka Prismawan,Ramon van der Vlag,Hao Guo et al.
Deka Prismawan et al.
Human 15-lipoxygenase-1 (15-LOX-1) belongs to the class of lipoxygenases, which catalyze oxygenation of polyunsaturated fatty acids, such as arachidonic and linoleic acid. Recent studies have shown that 15-LOX-1 plays an important role in p...
Metal Organic Polyhedra: A Click-and-Clack Approach Toward Targeted Delivery [0.03%]
金属有机多面体：一种针对目标递送的“即搭即扣”方法
Soumen K Samanta,Damien Moncelet,Brittany Vinciguerra et al.
Soumen K Samanta et al.
Mixed self-assembly of ligands 1 and 2, PXDA (3), and Pd(NO3)2 afforded metal organic polyhedra (MOP 1 - MOP 3) which bear 24 covalently attached CB[7] and cyclooctyne moieties. Post assembly modification (PAM) of MOP 3 by covalent strain p...
Cell Penetration, Herbicidal Activity, and in-vivo-Toxicity of Oligo-Arginine Derivatives and of Novel Guanidinium-Rich Compounds Derived from the Biopolymer Cyanophycin [0.03%]
寡精氨酸衍生物和富含胍基的新型化合物细胞穿透性，除草活性及体内毒性与来源于蓝藻素的生物聚合物的关系研究
Marcel Grogg,Donald Hilvert,Marc-Olivier Ebert et al.
Marcel Grogg et al.
Oligo-arginines are thoroughly studied cell-penetrating peptides (CPPs, Figures 1 and 2). Previous in-vitro investigations with the octaarginine salt of the phosphonate fosmidomycin (herbicide and anti-malaria drug) have shown a 40-fold par...