Hiroshi Nomura
Hiroshi Nomura
Motoko Maekawa,Karina Kimura,Jinghang Fu et al.
Motoko Maekawa et al.
Peroxisome proliferator-activated receptor α (PPARα) is a nuclear receptor that regulates lipid metabolism and inflammatory responses. Recent studies have revealed that PPARα also plays an important role in maintaining neuronal homeostas...
[Therapeutic potential of histamine N-methyltransferase inhibition for the treatment of hypersomnia] [0.03%]
组胺N-甲基转移酶抑制治疗嗜睡症的潜力
Fumito Naganuma,Takeo Yoshikawa
Fumito Naganuma
Histamine plays a crucial role in maintaining wakefulness. Decreased histamine levels in the cerebrospinal fluid have been reported in patients with hypersomnia, including narcolepsy and idiopathic hypersomnia. Histamine N-methyltransferase...
[Identifying common neural circuit dysfunctions across psychiatric disorders through neurophysiological indices] [0.03%]
基于神经生理指标的精神疾病共通神经环路障碍的识别
Hideki Miwa
Hideki Miwa
The etiology of psychiatric disorders such as schizophrenia, autism spectrum disorder (ASD), and depression remains largely unknown, and to date, no clear diagnostic criteria or curative pharmacological treatments have been established. One...
[Application of ATP dynamics visualization in live mice to central nervous system diseases] [0.03%]
【应用在体小鼠ATP动态可视化技术研究中枢神经系统疾病】
Ryosuke Ochi,Masamichi Yamamoto
Ryosuke Ochi
Adenosine triphosphate (ATP) is a crucial molecule which is used not only as an energy source in living organisms but also as a signaling molecule in various biochemical reactions. Real-time measurement of ATP dynamics in vivo is necessary ...
Takeo Yoshikawa
Takeo Yoshikawa
Takeshi Nagahiro,Kazuki Kakehi,Yuji Ikegaya et al.
Takeshi Nagahiro et al.
Yuichi Mazaki
Yuichi Mazaki
[Mechanism of action and clinical trial results of a new drug for amyotrophic lateral sclerosis (ALS), Mecobalamin (Rozebalamin®) for intramuscular injection, 25 mg] [0.03%]
新型肌萎缩侧索硬化症(ALS)药物注射用甲钴铵(Rozebalamin®)的机制和临床试验结果(25毫克肌肉注射)
Tetsuhiro Niidome,Takayuki Ishida
Tetsuhiro Niidome
Amyotrophic lateral sclerosis (ALS) is a progressive, intractable neurodegenerative disease characterized by generalized muscle atrophy and weakness, dysarthria, dysphagia, and respiratory muscle paralysis. Respiratory dysfunction due to mu...
Tomoyoshi Miyamoto,Maho Tsubota,Fumiko Sekiguchi et al.
Tomoyoshi Miyamoto et al.
Chemotherapy-induced peripheral neuropathy (CIPN) frequently develops following treatment of cancer with cytotoxic chemotherapeutics, such as taxanes, platinum-containing agents and vinca alkaloids, and leads to impairment of patients' QOL ...