[Non-clinical safety assessments using human cells for pediatric drug development] [0.03%]
基于人源细胞的非临床安全性评价在儿童用药研发中的应用
Yuta Sakamoto,Mitsuhiko Yamada,Yasunari Kanda et al.
Yuta Sakamoto et al.
Pediatric drug development is an urgent need to provide appropriate therapies for pediatric patients. Because children are undergoing continuous growth and development of their body and organs, pharmacological responses to the same drugs ma...
Hiroyuki Kawagishi
Hiroyuki Kawagishi
[Strategic evolution of drug discovery modalities: Tanabe Pharma's approach to immunology and oncology] [0.03%]
[Tanabe制药在免疫学和肿瘤学方面药物发现模式的战略演变]
Ryuichi Totsuka
Ryuichi Totsuka
Tanabe Pharma is advancing innovative drug discovery by selecting and designing optimal modalities based on disease characteristics, with a focus on neurological, immunological, and oncological disorders. This review outlines key initiative...
[Modality strategy in Eisai drug discovery: challenges toward next-generation therapeutics using proximity-inducing compound] [0.03%]
艾斯艾研究所的模态策略：利用邻接诱导化合物开发下一代药物的挑战与实践
Kazunobu Kira
Kazunobu Kira
In recent years, the concept of "modality" has attracted significant attention in drug discovery, encompassing diverse approaches such as small molecules, antibodies, nucleic acids, and cell-based therapies. Eisai has leveraged its long-sta...
Narihiro Toda
Narihiro Toda
In recent years, a wide variety of modalities, including small molecules, antibodies, nucleic acids, and gene therapies, have been successfully applied to drug discovery and have demonstrated significant achievements. The diversification an...
Teisuke Takahashi,Hisaharu Yamada
Teisuke Takahashi
[The role of the periaqueductal gray in behavioral selection under threat] [0.03%]
威胁下peri aqueductal灰质在行为选择中的作用
Natsuko Hitora-Imamura,Yuki Honshuku
Natsuko Hitora-Imamura
Fear responses and defensive behaviors are essential for survival, allowing animals to detect threatening stimuli and classify them as aversive. Neural circuits governing fear dynamically select adaptive defensive strategies, such as freezi...
[Current perspectives on the deep cerebellar nuclei in research on psychiatric and metabolic disorders] [0.03%]
有关深 cereb 脑核在精神病和代谢障碍研究的最新观点
Taiga Ishimoto,Chitoku Toda
Taiga Ishimoto
The cerebellum has historically been viewed as a key center for motor control and motor learning, with research primarily focusing on Purkinje cells as the core elements of its circuitry. However, accumulating evidence suggests a broader ro...
[Distinct prefrontal neuronal circuits determine repeated stress-induced behavioral styles in mice] [0.03%]
小鼠重复应激诱导的行为类型由不同的前额叶神经环路决定
Shusaku Uchida
Shusaku Uchida
Stressful experiences can initiate or exacerbate mental health conditions, including depression. Depression is a complex and diverse syndrome characterized by varying symptom profiles, progression patterns, and responses to treatment. Despi...
Yuki Takamura,Hiroshi Nomura
Yuki Takamura
Memory retrieval is not a static readout of fixed traces but a dynamic regulatory process where the accessibility of engrams, neuronal ensembles that are active during learning, fluctuates with internal and external states. Recent studies s...