[Epigenetic remodeling mechanisms in heart failure and their pathological significance] [0.03%]
心力衰竭表观遗传重编程机制及病理学意义研究进展
Masafumi Funamoto
Masafumi Funamoto
[Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies] [0.03%]
人源髓鞘化脑类器官与嵌合小胶质细胞作为髓鞘修复和脱髓鞘疾病治疗模型的研究
Natsuki Oe,Tatsunori Suzuki,Rieko Muramatsu
Natsuki Oe
Kisa Watanabe,Kano Izumo,Sena Iijima et al.
Kisa Watanabe et al.
[The preclinical profiles and the clinical efficacy and safety of vornorexant (Vorzzz® tablets), a new orexin receptor antagonist] [0.03%]
沃诺雷新(Vorzzz®片剂)的临床前特征及其疗效和安全性研究
Haruka Yokota,Yukihiro Chino,Kayoko Shibayama et al.
Haruka Yokota et al.
Traditionally, benzodiazepines and non-benzodiazepines have been primary pharmacological treatments for insomnia. The introduction of orexin receptor antagonists has provided safer alternatives. Orexin is a neuropeptide involved in maintain...
[The physiological roles of primary ciliary resorption and its potential as therapeutic targets] [0.03%]
主纤毛回摆的生理作用及其作为治疗靶点的潜力
Masaki Saito,Gen-Ichi Atsumi
Masaki Saito
Primary cilia are cellular antennae protruding from the surface of nearly all cell types during the G0 phase. They control the organization and maturation of systemic tissues and organs by receiving selective signals. Ciliopathies are herit...
[Regulation of primary cilia targeting the interaction between aurora kinase A and trichoplein] [0.03%]
主纤毛调控aurora kinase A与trichopltein相互作用的机制研究
Yuhei Nishimura
Yuhei Nishimura
The primary cilium is an antenna-like protruding organelle that detects various signals and changes its length according to the context, thereby regulating cellular functions such as proliferation, differentiation, and migration properly. T...
[Comprehensive characterization of primary ciliated cells in inflammatory skin diseases] [0.03%]
[炎症性皮肤病原代纤毛细胞的全面表征]
Mikihito Ike,Manami Toriyama
Mikihito Ike
Primary cilia are non-motile organelles that act as cellular "antennas" to sense extracellular signals. As functional studies of primary cilia across various organs and tissues have progressed, it has become clear that primary cilia are als...
[Cholesterol in the ciliary membrane as a therapeutic target of polycystic kidney] [0.03%]
胆固醇作为多囊肾疾病睫状膜治疗靶点的可能性
Tomoka Morita,Moe Hirosawa,Takeshi Itabashi et al.
Tomoka Morita et al.
Primary cilia are non-motile, microtubule-based cellular protrusions that sense extracellular chemical and mechanical cues, converting them into intracellular signals. Ciliary dysfunction causes ciliopathies including polycystic kidney dise...
Masaki Saito,Yuhei Nishimura
Masaki Saito
[Pediatric drug development: current landscape, challenges, and future directions] [0.03%]
儿科药物研发：现状、挑战与未来方向
Chie Emoto,Tsuyoshi Fukuda
Chie Emoto
Pediatric drug development has seen significant progress through the implementation of extrapolation strategies incorporating modeling and simulation (M&S) techniques. The ICH E11A guideline provides a systematic framework for pediatric ext...