RTKN2 Enhances Radioresistance in Gastric Cancer through Regulating the Wnt/β-Catenin Signalling Pathway [0.03%]
RTKN2通过调节Wnt/β-catenin信号通路增强胃癌的放射抵抗性
H-G Zhao,J-J Yin,X Chen et al.
H-G Zhao et al.
Adjuvant therapy and radiotherapy improves the survival of patients with metastatic and locally advanced gastric cancer (GC). However, the resistance to radiotherapy limits its clinical usage. Rhotekin 2 (RTKN2) functions as an oncogene and...
PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway [0.03%]
高糖通过调控Wnt/β-catenin信号通路促进视网膜内皮细胞血管生成和迁移PLAG1的作用
Q Gu,H-F Wei
Q Gu
Proliferation and migration of retinal endothelial cells (RECs) contribute to the development of diabetic retinopathy. PLAG1 (pleomorphic adenoma gene 1) functions as a zinc-finger transcription factor to participate in the development of l...
C-Phycocyanin Suppresses Cell Proliferation and Promotes Apoptosis by Regulating the AMPK Pathway in NCL-H292 Non-Small Cell Lung Cancer Cells [0.03%]
C-藻蓝蛋白通过调节AMPK途径抑制NCL-H292非小细胞肺癌细胞的增殖并促进其凋亡
H Chaowen,H Dongxuan,H Dongsheng et al.
H Chaowen et al.
Non-small cell lung cancer (NSCLC) results in high mortality and has gained increasing attention. C-Phycocyanin (C-PC) has been identified as a potential therapeutic inhibitor for NSCLC, but its underlying mechanism remains obscure. The gen...
Ferroptosis-Related Long Noncoding RNA Signature Predicts Prognosis of Clear Cell Renal Carcinoma [0.03%]
铁死亡相关长链非编码RNA特征可预测透明细胞肾癌预后
J W Liu,F Supandi,S K Dhillon
J W Liu
Clear cell renal cell carcinoma (ccRCC) is very common and accounts for most kidney cancer deaths. While many studies are being conducted in finding the prognostic signatures of ccRCC, we believe that ferroptosis, which involves programmed ...
Prostaglandin F2α Causes Fast Degenerative Changes in Ovulated Mouse Oocytes [0.03%]
前列腺素F2α导致小鼠卵母细胞快速退变
A I Kolarov,V P Hadzhinesheva,I V Chakarova et al.
A I Kolarov et al.
The effects of prostaglandin F2α on the cytoskeleton and membrane organelles of oocytes was investigated by culturing ovulated mouse oocytes in its presence (50 or 100 ng/ml) for 3 h. Tubulin, fibrillar actin, membranes and chromatin were ...
MiR-503 Contributes to Glucocorticoid Sensitivity in Acute Lymphoblastic Leukaemia via Targeting WNT3A [0.03%]
微RNA-503通过靶向WNT3A促进急性淋巴细胞白血病对糖皮质激素的敏感性
C Tian,L Liu,M Zheng et al.
C Tian et al.
Abnormal accumulation of lymphoblasts in the blood and bone marrow is the main characteristic of acute lymphoblastic leukaemia (ALL). Glucocorticoids are effective drugs for ALL, while glucocorticoid resistance is an obstacle to ALL therapy...
JAB1 Promotes High Glucose-Induced Inflammation and Extracellular Matrix Deposition in Glomerular Mesangial Cells by Regulating Angiopoietin-Like Protein 2 [0.03%]
JAB1通过调节血管生成素样蛋白2促进高糖诱导的系膜细胞炎症及细胞外基质沉积
P Zhu,Y Wu,Y Gu et al.
P Zhu et al.
Diabetic or hyperglycaemic conditions stimulate the inflammatory response, excessive accumulation of extracellular matrix, and result in glomerulosclerosis, a scarring process of diabetic nephropathy. c-Jun activation domain-binding protein...
Over-expression of Apolipoprotein J Inhibits Cholesterol Crystal-Induced Inflammatory Responses via Suppressing NLRP3 Inflammasome Activation in THP-1 Macrophages [0.03%]
apoJ过表达通过抑制NLRP3炎性小体活化来抑制胆固醇结晶诱导的炎症反应
Y Li,Y-Q Song,Y Zhang et al.
Y Li et al.
Apolipoprotein J (clusterin) is a component of high-density lipoproteins, the high level of which is reversely correlated with the risk of coronary heart disease. In addition, it exerts anti-inflammatory and anti-apoptotic effects on endoth...
Tri-Lineage Differentiation of NTERA2 Clone D1 Cells towards Neural, Hepatic and Osteogenic Lineages in Vitro [0.03%]
NTERA2CloneD1细胞体外向神经、肝和成骨方向三系分化的研究
B Szeky,B Mayer,M Gyongy et al.
B Szeky et al.
Over the past decades, the in vitro use of pluripotent cell lines gained a crucial role in toxicology, preclinical drug testing and developmental biology. NTERA2 clone D1 cells were identified as pluripotent cells with high potential for ne...
Identification of Schizosaccharomyces pombe ird Mutants Resistant to Glucose Suppression and Oxidative Stress [0.03%]
耐葡萄糖阻遏和氧化应激的裂殖酵母Schizosaccharomyces pombe ird突变株的鉴定
M Yilmazer,B Bayrak,B Kartal et al.
M Yilmazer et al.
Glucose is both the favourite carbon and energy source and acts as a hormone that plays a regulating role in many biological processes. Calorie restriction extends the lifespan in many organisms, including Schizosaccharomyces pombe, while u...