Atractylenolide III Promotes Astrocyte Aβ Clearance by Up-regulating AQP4 to Improve Alzheimer's Disease [0.03%]
穿心莲内酯III通过上调水通道蛋白AQP4促进星形胶质细胞Aβ清除改善阿尔茨海默病
Jingwen Hao,Qi Wan,Chanjuan Chen
Jingwen Hao
Astrocytes actively phagocytose amyloid beta (Aβ), enhancing cerebral clearance and positioning themselves as viable therapeutic targets for Alz-heimer's disease (AD). Atractylenolide III (ATL-III), the primary bioactive compound in the tr...
Comprehensive Analysis of Hub Telomere-Related Genes and Synovial Immune Characteristics in Osteoarthritis [0.03%]
骨关节炎中心性端粒相关基因及滑膜免疫特征的全面分析
Chunxiao Du,Weidan Xu
Chunxiao Du
Osteoarthritis (OA) is a degenerative arthritis associated with aging. It is recognized that telomere attrition is a hallmark of aging. However, the transcriptional dynamics of synovial telomere-related genes (TRGs) in OA has not yet been e...
The Impact of Detachment Methods (Trypsin, Accutase, and Accumax) on the Expression of Stem Cell Markers CXCR4 and CD146 [0.03%]
不同消化方法对多能干细胞标志物CXCR4和CD146表达的影响分析
Wail Abou Assaf,Jan Schmidt,Nela Jouklová et al.
Wail Abou Assaf et al.
Trypsin (TRY) combined with ethylenediaminetetraacetic acid (EDTA) is a widely used dissociation agent due to its efficiency and cost-effectiveness. However, its impact on preserving stem cell marker expression, such as C-X-C chemokine rece...
Dysregulated BARD1 Contributes to Paclitaxel Resistance in Ovarian Cancer via Up-regulating CYP2C8 [0.03%]
BARD1失调通过上调CYP2C8促进卵巢癌紫杉醇耐药
Li Zhang,Zixuan Pan,Liqin Zhang et al.
Li Zhang et al.
Ovarian cancer remains one of the most lethal gynaecological malignancies, with paclitaxel resistance being a major therapeutic challenge that limits treatment efficacy and patient survival. We found that although the BARD1 level was not si...
Genetic and Non-Genetic Risk Factors in Prostate Cancer: Towards a Precision Medicine Approach [0.03%]
前列腺癌的遗传和非遗传风险因素：精确医学方法的研究进展
Stanislav Hloušek,Soňa Argalácsová,Jana Soukupová et al.
Stanislav Hloušek et al.
Prostate cancer (PCa) represents the most common malignancy among men in many countries, including the Czech Republic. While most cases are sporadic, approximately 10 % are attributed to hereditary factors, particularly germline pathogenic ...
Semi-automated RNA Isolation from Tempus Blood RNA Tubes Using the Magcore Plus II Instrument [0.03%]
使用MagCore Plus II仪器对Tempus血液RNA管进行半自动化RNA提取
Marta Černá,Barbora Šťastná,Pavel Pešek et al.
Marta Černá et al.
High-throughput, precise and cost-effective isolation of high-quality RNA is essential for the growing number of RNA-based next-generation sequencing (NGS) analyses. Manual RNA isolation provides sufficient quality but requires significant ...
Exploring the Clinical Significance and Mechanistic Role of the LINC00487/hsa-miR-663b Axis in Cell Line Models of Acute Lung Injury [0.03%]
探究LINC00487/hsa-miR-663b轴在急性肺损伤细胞系模型中的临床意义及作用机制
Xixiang Yan,Ziqi Xie,Xiaoye Zheng et al.
Xixiang Yan et al.
Acute lung injury (ALI) is a serious lung disease that tends to progress to acute respiratory distress syndrome (ARDS). This study was aimed to seek new biomarkers of ALI to provide a basis for monitoring the progress of ALI in time. A huma...
Motaz Fadul,Saleh Baeesa,Alaa Alkhotani et al.
Motaz Fadul et al.
Medulloblastoma (MB) in children is associated with distinct molecular subgroups, reflecting substantial biological heterogeneity. The presence of isocitrate dehydrogenase 1 (IDH1) and IDH2 mutations in paediatric MB has been rarely reporte...
miR-296-3p Controls Osteogenic Proliferation and Differentiation by Targeting ICAT and Is Involved in Fracture Healing [0.03%]
微RNA-296通过靶向ICAT控制骨形成增殖和分化并参与骨折愈合
Feng Xu,Kun Huang,Wenjun Ji et al.
Feng Xu et al.
Fragility fractures have been a cause for concern because of their high incidence. For the prevention and treatment of osteoporotic fractures, it is important to understand how to promote bone formation and increase bone mass. This study in...
Petr Janec,Jana Dorňáková,Jan Živný et al.
Petr Janec et al.
The endothelium plays a crucial role in maintaining vascular homeostasis. Inflammation is initiated by activation of endothelial cells, which results in endothelial dysfunction. Dysfunction of the endothelium can have significant consequenc...