Chondrosarcoma with Target-Like Chondrocytes: Update on Molecular Profiling and Specific Morphological Features [0.03%]
具有靶环样软骨细胞的软骨肉瘤：分子谱特征及形态学特点进展
C Povýšil,J Hojný,M Kaňa
C Povýšil
This is the first histological and molecular analysis of two chondrosarcomas with target-like chondrocytes that were compared with a group of conventional chondrosarcomas and enchondromas. The unique histological feature of target-like chon...
NFKB1 Signalling Activation Contributes to TRPV1 Over-expression via Repressing MiR-375 and MiR-455: a Study on Neuropathic Low Back Pain [0.03%]
NFKB1信号激活通过抑制MiR-375和MiR-455促进TRPV1过表达：一项关于神经源性下腰痛的研究
Z Li,Y Zhou,Z Li
Z Li
Transient receptor potential cation channel subfamily V member 1 (TRPV1) has been found over-expressed in low back pain (LBP) patients with neuropathic pain (NP), but the underlying mechanism is still unclear. In the present study, the up-r...
Dynamic Molecular Profiles of Bone Marrow-Derived Osteoblasts at the Single-Cell Level [0.03%]
单细胞分辨率下单个骨髓来源成骨细胞的动态分子图谱
M Cao,J Xie,Y Hu et al.
M Cao et al.
Osteogenesis is an important process of bone metabolism, and abnormal osteogenesis leads to various skeletal system diseases. Osteoblasts, the main cells involved in bone formation, are central elements in the study of bone metabolic diseas...
Polyphenols of Antibacterial Potential - May They Help in Resolving Some Present Hurdles in Medicine? [0.03%]
具有抗菌潜力的多酚-它们能帮助解决医学上的一些难题吗？
K Zapletal,G Machnik,B Okopień
K Zapletal
The phenomenon of antibiotic resistance has been recognized as one of the greatest threats to humanity. Therefore, there is an enormous need to introduce new antibiotics to the medical practice that will effectively eradicate the resistant ...
MicroRNA-214-3p Ameliorates LPS-Induced Cardiomyocyte Injury by Inhibiting Cathepsin B [0.03%]
微小核糖核酸-214-3p通过抑制组织蛋白酶B改善LPS诱导的心肌细胞损伤
W Yan,Y Feng,Z Lei et al.
W Yan et al.
Myocardial injury is a common complication of sepsis. MicroRNA (miRNA) miR-214-3p is protective against myocardial injury caused by sepsis, but its mechanism in lipopolysaccharide (LPS)- induced cardiomyocyte injury is still unclear. An AC1...
TRPM7 Elicits Proliferation and Differentiation of Human Lens Epithelial Cells through the TGF-β/Smad Pathways [0.03%]
TRPM7通过TGF-β/Smad通路促进人晶状体上皮细胞的增殖与分化
G Yang,Y Wu,S Tang
G Yang
Epithelial-mesenchymal transition (EMT) plays a crucial role in the development of cataract. This study aimed to explore the effects of TRPM7 on the proliferation and differentiation of human lens epithelial cells. TRPM7 was over-expressed ...
Docosahexaenoic Acid Reverses Epithelial-Mesenchymal Transition and Drug Resistance by Impairing the PI3K/AKT/ Nrf2/GPX4 Signalling Pathway in Docetaxel-Resistant PC3 Prostate Cancer Cells [0.03%]
二十二碳六烯酸通过破坏PI3K / AKT / Nrf2 / GPX4信号通路逆转-docetaxel抵抗的PC3前列腺癌细胞的上皮间充质转化和药物抗性
Z C Shao,B H Zhu,A F Huang et al.
Z C Shao et al.
Drug resistance is a serious problem in cancer therapy. Growing evidence has shown that docosahexaenoic acid has anti-inflammatory and chemopreventive abilities. Studies have shown that autophagy inhibition and ferroptosis are promising the...
Validation of the Anti-Inflammatory Effect of Tenebrio Molitor Larva Oil in a Colitis Mouse Model [0.03%]
黄粉虫油对结肠炎小鼠模型抗炎效果的验证研究
B M Park,J Lee,B G Jung et al.
B M Park et al.
Ulcerative colitis is caused by various external factors and is an inflammatory disease that causes decreased intestinal function. Tenebrio molitor larvae contain more than 30 % fat, and the fat component consists of 45 % oleic acid, 20 % l...
Time and Temperature Stability of TGF-β1, EGF and IGF-1 in 20% and 100% Human Serum [0.03%]
转化生长因子-β1、表皮生长因子和胰岛素样生长因子-1在20%和100%人血清中的时效及温度稳定性研究
K Jirsova,K Levova,M Kalousova et al.
K Jirsova et al.
Autologous serum eye drops (ASEDs) are used as a treatment for severe dry eye disease. The concentration and stability of various growth factors in ASEDs is determinative for their efficiency. We therefore assessed the concentrations of tra...
RNA Concentration and Content in the Nucleoli and Cytoplasmic Rim in Differentiating Lymphocytes of Patients Suffering from B Chronic Lymphocytic Leukaemia - a Cytochemical Note [0.03%]
慢性B淋巴细胞性白血病患者分化淋巴细胞中的核仁和细胞边缘的RNA浓度与含量-细胞化学说明
K Smetana,D Mikulenková,J Karban et al.
K Smetana et al.
Nucleolar RNA optical density (concentration) measurements at the single cell level indicated that differentiation of lymphocytes is accompanied by a slightly decreased nucleolar RNA concentration in contrast to the cytoplasmic rim around t...