Early-Onset Neonatal Sepsis: Inflammatory Biomarkers and MicroRNA as Potential Diagnostic Tools in Preterm Newborns [0.03%]
早发性新生儿败血症：炎症生物标志物和微小核糖核酸作为潜在的诊断工具在早产儿中的应用
Petr Janec,Marek Mojžíšek,Martin Pánek et al.
Petr Janec et al.
Mortality and morbidity of newborns with sepsis can be improved by early and accurate diagnosis and targeted therapy. To evaluate the early molecular events associated with inflammation and infection, we evaluated markers of endothelial act...
MiR-19a-3p Promotes Aerobic Glycolysis in Ovarian Cancer Cells via IGFBP3/PI3K/AKT Pathway [0.03%]
miR-19a-3p通过IGFBP3/PI3K/AKT途径促进卵巢癌细胞的有氧糖酵解
Lijun Du,Kaikai Dou,Dan Zhang et al.
Lijun Du et al.
Aerobic glycolysis is a prominent feature of cancer. Here, we reported that miR-19a-3p promotes aerobic glycolysis in ovarian cancer cells SKVO3 and ES-2 by increased production of ATP, lactic acid, extracellular acidification (ECAR), and i...
Autotaxin and Lysophosphatidic Acid Signalling: the Pleiotropic Regulatory Network in Cancer [0.03%]
溶血磷脂酸信号通路：癌症中的多功能调控网络
Ondřej Vít,Jiří Petrák
Ondřej Vít
Autotaxin, also known as ecto-nucleotide pyrophosphatase/phosphodiesterase family member 2, is a secreted glycoprotein that plays multiple roles in human physiology and cancer pathology. This protein, by converting lysophosphatidylcholine i...
Diagnostic and Prognostic Profiling of Nucleocytoplasmic Shuttling Genes in Hepatocellular Carcinoma [0.03%]
核质关往返基因在肝细胞癌中的诊断和预后特征分析
Samuel Herceg,Radoslav Janoštiak
Samuel Herceg
One of the key features of eukaryotic cells is the separation of nuclear and cytoplasmic compartments by a double-layer nuclear envelope. This separation is crucial for timely regulation of gene expression, mRNA biogenesis, cell cycle, and ...
A Pilot Study on the Uptake of Propidium Iodide and YO-PRO-1 Iodide through the Pannexin Channels in Wallachian Frozen-Thawed Ram Spermatozoa [0.03%]
Wallachian冷冻解冻公羊精子Pannexin通道对碘化丙啶和YO-PRO-1碘化物的摄取研究初报
Filipp Georgijevič Savvulidi,Martin Ptáček,Anežka Málková et al.
Filipp Georgijevič Savvulidi et al.
Propidium iodide (PI) and YO-PRO-1 (YPI) dyes are routinely used to determine sperm viability in many livestock species. It is commonly accepted that these dyes penetrate only sperm cells with damaged plasma membranes. Recently, however, th...
Redox Status of Erythrocytes as an Important Factor in Eryptosis and Erythronecroptosis [0.03%]
红细胞的氧化还原状态作为溶血和红细咆凋亡的一个重要因素
Anton Tkachenko,Ondřej Havránek
Anton Tkachenko
Overall, reactive oxygen species (ROS) signalling significantly contributes to initiation and mo-dulation of multiple regulated cell death (RCD) pathways. Lately, more information has become available about RCD modalities of erythrocytes, i...
Germline Pathogenic Variants in Squamous Cell Carcinoma of the Head and Neck [0.03%]
头颈部鳞状细胞癌中的生殖系致病变异
Tereza Drbohlavová,Soňa Argalácsová,Jana Soukupová et al.
Tereza Drbohlavová et al.
Head and neck squamous cell carcinoma (HNSCC) presents a significant global health problem with variable geographic distribution and risk factors, including tobacco and alcohol abuse, human papillomavirus infections, and genetic predisposit...
De novo Transcriptome Analysis and Gene Expression Profiling of Corylus Species [0.03%]
榛属植物的从头转录组分析和基因表达谱分析
Salih Ulu,Zehra Omeroglu Ulu,Aysun Akar et al.
Salih Ulu et al.
Hazelnut (Corylus), which has high commercial and nutritional benefits, is an important tree for producing nuts and nut oil consumed as ingredient especially in chocolate. While Corylus avellana L. (Euro-pean hazelnut, Betulaceae) and Coryl...
Radiation-Induced Lymphopoenia and Treatment Outcome in Hereditary Breast Cancer Patients [0.03%]
放射线诱导的淋巴细胞减少与遗传性乳腺癌患者治疗结果的关系
Soňa Argalácsová,Ľudmila Křížová,Martin Matějů et al.
Soňa Argalácsová et al.
Many breast cancer (BC) predisposition genes encode proteins involved in DNA damage repair (DDR). Identification of germline pathogenic va-riants (PV) in DDR genes raises the question whether their presence can influence the treatment outco...
Homeobox Protein PROX1 Expression is Negatively Regulated by Histone Deacetylase 1 and c-JUN Complex in MDA-MB-231 Human Breast Cancer Cells [0.03%]
家禽组蛋白脱乙酰基酶1和c-JUN复合体在MDA-MB-231人乳腺癌细胞中对Homeobox Protein PROX1的表达起到负调控作用
Munki Jeong,Euitaek Jung,Sukjin Oh et al.
Munki Jeong et al.
Prospero homeobox 1 (PROX1) is a member of the homeobox transcription factor family that plays a critical role in the development of multiple tissues and specification of cell fate. PROX1 expression is differentially regulated based on the ...