circRACGAP1 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through the miR-1296/CDK2 Pathway [0.03%]
circRACGAP1通过miR-1296/CDK2通路促进非小细胞肺癌细胞增殖
Yang Zhao,Liyong Deng,Yi Xie et al.
Yang Zhao et al.
Circular RNAs (circRNAs) have played an essential role in cancer development. This study aimed to illustrate the impact and potential mechanism of circRACGAP1 action in NSCLC development. The expression patterns of circRACGAP1, miR-1296, an...
miR-325 Supresses Cell Proliferation and Migration in Non-Small Cell Lung Cancer via Targeting DNA Ligase 1 (LIG1) [0.03%]
microRNA-325通过靶向DNA连接酶1抑制非小细胞肺癌的增殖和迁移
Maixia Yu,Linchan Li,Peng Xu
Maixia Yu
DNA ligase 1 (LIG1) plays a key role in DNA synthesis and DNA damage repair pathways. LIG1 has been shown to be up-regulated in human non-small cell lung cancer (NSCLC); however, its role and molecular regulatory mechanism in NSCLC cell pro...
Integrating Lysosomal Genes and Immune Infiltration for Multiple Myeloma Subtyping and Prognostic Stratification [0.03%]
溶酶体基因和免疫浸润在多发性骨髓瘤分类和预后分层中的作用
Shu Deng,Jingjing Xiangang,Zhiyin Zheng et al.
Shu Deng et al.
Lysosomes are crucial in the tumour immune microenvironment, which is essential for the survival and homeostasis in multiple myeloma (MM). Here, we aimed to identify lysosome-related genes for the prognosis of MM and predicted their regulat...
Reactive Oxygen Species Modulate Th17/Treg Balance in Chlamydia psittaci Pneumonia via NLRP3/IL-1β/Caspase-1 Pathway Differentiation [0.03%]
NLRP3/IL-1β/Caspase-1信号途径介导的反应氧中间物调节鹦鹉热衣原体肺炎中Th17/Treg平衡分化
Rong Jiang,Haibo Zhou,Xianglong Kong et al.
Rong Jiang et al.
Chlamydia psittaci pneumonia (CPP) is a lung disease caused by the infection with the Chla-mydia psittaci bacterium, which can lead to severe acute respiratory distress syndrome and systemic symptoms. This study explored the specific mechan...
Parallel DNA/RNA NGS Using an Identical Target Enrichment Panel in the Analysis of Hereditary Cancer Predisposition [0.03%]
利用相同的目标富集板块进行的平行DNA / RNA下一代测序在遗传性癌症易感性的分析中的应用
Petra Kleiblová,Marta Černá,Petra Zemánková et al.
Petra Kleiblová et al.
Germline DNA testing using the next-gene-ration sequencing (NGS) technology has become the analytical standard for the diagnostics of hereditary diseases, including cancer. Its increasing use places high demands on correct sample identifica...
Gallic Acid Alleviates Psoriasis Keratinization and Inflammation by Regulating BRD4 Expression [0.03%]
没食子酸通过调节BRD4表达缓解银屑病角化和炎症
Li Zhang,Qiaoyuan Ye,Saiyang Gan et al.
Li Zhang et al.
Psoriasis is a chronic non-contagious autoimmune disease. Gallic acid is a natural compound with potential health benefits, including antioxidant, anticancer, antiviral and antibacterial properties. Nevertheless, the influence of gallic aci...
Taurine Improved Autism-Like Behaviours and Defective Neurogenesis of the Hippocampus in BTBR Mice through the PTEN/mTOR/AKT Signalling Pathway [0.03%]
牛磺酸通过PTEN/mTOR/AKT信号通路改善BTBR小鼠自闭症样行为和海马区神经发生的缺陷
Huang Xiaoyan,Yang Zhaoxi,Zhang Lingli et al.
Huang Xiaoyan et al.
Effective treatment of patients with autism spectrum disorder (ASD) is still absent so far. Taurine exhibits therapeutic effects towards the autism-like behaviour in ASD model animals. Here, we determined the mechanism of taurine effect on ...
Libor Macůrek
Libor Macůrek
Cyclin-dependent kinases (CDKs) are master regulators of proliferation, and therefore they represent attractive targets for cancer therapy. Deve-lopment of selective CDK4/6 inhibitors including palbociclib revolutionized the treatment of ad...
Guangyu Wang,Xu Tian,Lintao Liu et al.
Guangyu Wang et al.
We explored the mechanism of human osteosarcoma MG-63 cell apoptosis induced by asta-xanthin. The MTT assay was used to detect the effect of astaxanthin on cell viability. Morphological changes associated with apoptosis were observed after ...
CD14 Polymorphism Is Not Associated with SARS-CoV-2 Infection in Central European Population [0.03%]
中央欧洲人群的CD14基因多态性与SARS-CoV-2感染无关
Jaroslav A Hubáček,Tom Philipp,Ondřej Májek et al.
Jaroslav A Hubáček et al.
A 2021 in silico study highlighted an association between the CD14 polymorphism rs2569190 and increased susceptibility to SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19). The aim of our study was to confirm this finding. We ana...