Down-regulation of JCAD Expression Attenuates Cardiomyocyte Injury by Regulating the Wnt/β-Catenin Pathway [0.03%]
JCAD表达下调通过调节Wnt/β-catenin信号通路缓解心肌细胞损伤
Can Li,Zhengdong Liu,Dong Liu et al.
Can Li et al.
Coronary heart disease (CHD) is one of the most commonly seen cardiovascular conditions across the globe. Junctional cadherin 5 associated (JCAD) protein is found in the intercellular junctions of endothelial cells and linked to cardiovascu...
Effects of Different Light Environments with Varying Spectral Composition on the Axial Lengths and Scleral Specificity Protein 1 and Collagen Type I Expression in Juvenile Guinea Pigs [0.03%]
不同光环境下谱组成变化对幼年 Guinea 猪眼轴长度及巩膜 SP1 和Ⅰ型胶原蛋白表达的影响
Jianbao Yuan,Yuliang Wang,Xinyu Xu et al.
Jianbao Yuan et al.
The study aimed to investigate changes in the eye axial length in juvenile guinea pigs and the expression of scleral specificity protein 1 (Sp1) and collagen type I (Col-I) under different light environments with varying spectral compositio...
Effect of Cryoprotectants on Long-Term Storage of Oral Mucosal Epithelial Cells: Implications for Stem Cell Preservation and Proliferation Status [0.03%]
冷冻保护剂对口腔粘膜上皮细胞长期保存的影响：干细胞保存和增殖状态的启示
Joao Victor Cabral,Natálie Smorodinová,Eleni Voukali et al.
Joao Victor Cabral et al.
In this study, we tested a method for long-term storage of oral mucosal epithelial cells (OMECs) so that the cells could be expanded in vitro after cryopreservation and used for the treatment of bilateral limbal stem cell deficiency. The ab...
CD8+ T-Cell Signatures as Prognostic and Immunotherapy Response Predictors in Non-Small Cell Lung Cancer [0.03%]
非小细胞肺癌中的CD8+t细胞特征作为预后和免疫治疗反应预测指标的研究
Tienan Zhao,Sarinder Kaur Dhillon
Tienan Zhao
Non-small cell lung carcinoma (NSCLC) represents the majority of lung cancer cases, comprising approximately 85 % of the total. The five-year survival rate for NSCLC patients remains discouragingly low. Recently, immunotherapy has emerged a...
Predictive Value of T-Lymphocyte Subsets in Combination with Serum Tumour Markers for Prognosis of Patients with Non-Small Cell Lung Cancer Undergoing Chemotherapy [0.03%]
T淋巴细胞亚群联合血清肿瘤标志物预测非小细胞肺癌化疗患者预后的价值
Jinfeng Zhang
Jinfeng Zhang
We aimed to detect the levels of T-lympho-cyte subsets and serum tumour markers in patients with non-small cell lung cancer (NSCLC) before chemotherapy, and to investigate the predictive value of their combined detection for the prognosis o...
Docosahexaenoic Acid Promotes Eryptosis and Haemolysis through Oxidative Stress/Calcium/Rac1 GTPase Signalling [0.03%]
二十二碳六烯酸通过氧化应激/钙离子/Rac1鸟苷三磷酸酶信号促进红细胞凋亡和溶血
Feryal H Alharthy,Jawaher Alsughayyir,Mohammad A Alfhili
Feryal H Alharthy
Docosahexaenoic acid (DHA) is an omega-3 polyunsaturated fatty acid with promising anticancer potential. Anaemia is a frequent adverse effect of anticancer treatment caused in part by eryptosis and haemolysis. Thus, it is important to inves...
Exploration of the Development and Cell Communication of Aneuploid Osteoblasts and Osteoclasts in Giant Cell Tumour of Bone Using Single-Cell RNA Sequencing [0.03%]
单细胞RNA测序在骨巨细胞瘤中的应用：非整倍体成骨细胞和破骨细胞的发育及细胞通讯研究
Bo-Hua Gao,Yan Wang,Ye Zhang et al.
Bo-Hua Gao et al.
We aimed to explore the development and cell communication of osteoblasts and osteoclasts with aneuploidy variation in giant cell tumour of bone (GCTB). We predicted the diploid and aneuploid cells in tissue samples using the CopyKAT packag...
Heat Shock Protein Network: the Mode of Action, the Role in Protein Folding and Human Pathologies [0.03%]
热休克蛋白网络：作用模式、在蛋白质折叠中的作用及与人类病理的关系
Aleksandr Melikov,Petr Novák
Aleksandr Melikov
Protein folding is an extremely complicated process, which has been extensively tackled during the last decades. In vivo, a certain molecular machinery is responsible for assisting the correct folding of proteins and maintaining protein hom...
Jana Seňavová,Anežka Rajmonová,Václav Heřman et al.
Jana Seňavová et al.
T-cell lymphomas (TCLs) are a rare and heterogeneous subgroup of non-Hodgkin lymphomas (NHLs), forming only 10 % of all NHL cases in Western countries. Resulting from their low incidence and heterogeneity, the current treatment outcome is g...
TET3 Protein Represses Proliferation of the MG-63 Human Osteosarcoma Cell Line by Regulating DNA Demethylation: an Epigenetic Study [0.03%]
TET3蛋白通过调节DNA去甲基化抑制MG-63人成骨肉瘤细胞系增殖：表观遗传学研究
Shijun Hang,Bingjun Cui,Aichun Wei et al.
Shijun Hang et al.
Recent studies have highlighted the significant role of 5-hydroxymethylcytosine (5hmC) in carcinogenesis. However, the specific role of 5hmC in osteosarcoma (OS) remains largely unexplored. The-re-fore, this study aimed to investigate the f...