Styrene maleic acid derivates to enhance the applications of bio-inspired polymer based lipid-nanodiscs [0.03%]
基于仿生聚合物的脂质纳米盘的应用增强： styrene-maleic acid 衍生物的作用
Thirupathi Ravula,Nathaniel Z Hardin,Giacomo M Di Mauro et al.
Thirupathi Ravula et al.
Membrane mimetics are essential to study the structure, dynamics and function of membrane-associated proteins by biophysical and biochemical approaches. Among various membrane mimetics that have been developed and demonstrated for studies o...
POxylation as an alternative stealth coating for biomedical applications [0.03%]
用于生物医学应用的POxylation隐身涂层的新方法
Herdis Bludau,Anna E Czapar,Andrzej S Pitek et al.
Herdis Bludau et al.
Polyethylene glycol (PEG) polymers are currently used in a variety of medical formulations to reduce toxicity, minimize immune interactions and improve pharmacokinetics. Despite its widespread use however, the presence of anti-PEG antibodie...
UV-mediated thiol-ene click reactions for the synthesis of drug-loadable and degradable gels based on copoly(2-oxazoline)s [0.03%]
基于共聚（2-恶唑烷）的载药和可降解凝胶的紫外光介导的硫醇-烯烃点击反应合成技术
Klaus P Luef,Charlotte Petit,Bettina Ottersböck et al.
Klaus P Luef et al.
An 80-membered library of gels composed of monofunctional 2-ethyl-2-oxazoline and 2-nonyl-2-oxazoline and one of four selected difunctional 2-oxazolines (containing either ether or ester bonds) were synthesized by microwave-assisted ring-op...
Preparation and antimicrobial evaluation of polyion complex (PIC) nanoparticles loaded with polymyxin B [0.03%]
聚阳离子复合物(PIC)纳米颗粒载多粘菌素B的制备及抗菌评价
Ignacio Insua,Sieta Majok,Anna F A Peacock et al.
Ignacio Insua et al.
Here, we describe novel polyion complex (PIC) particles for the delivery of Polymyxin B (Pol-B), an antimicrobial peptide currently used in the clinic as a last resort antibiotic against multidrug-resistant gram-negative bacteria. A range o...
Polyion complex (PIC) particles: Preparation and biomedical applications [0.03%]
聚离子复合物(PIC)颗粒的制备及生物医药应用
Ignacio Insua,Andrew Wilkinson,Francisco Fernandez-Trillo
Ignacio Insua
Oppositely charged polyions can self-assemble in solution to form colloidal polyion complex (PIC) particles. Such nanomaterials can be loaded with charged therapeutics such as DNA, drugs or probes for application as novel nanomedicines and ...
Gelation characteristics, physico-mechanical properties and degradation kinetics of micellar hydrogels [0.03%]
胶束水凝胶的凝胶特性、物理力学性能及降解动力学
Seyedsina Moeinzadeh,Esmaiel Jabbari
Seyedsina Moeinzadeh
Due to their high water content and diffusivity of nutrients and biomolecules, hydrogels are very attractive as a matrix for growth factor immobilization and in situ delivery of cells to the site of regeneration in tissue engineering. The f...
Gaelle C Le Goff,Rathi L Srinivas,W Adam Hill et al.
Gaelle C Le Goff et al.
Due to their hydrophilic, biocompatible, and highly tunable nature, hydrogel materials have attracted strong interest in the recent years for numerous biotechnological applications. In particular, their solution-like environment and non-fou...
Nicholas M Matsumoto,George W Buchman,Leonard H Rome et al.
Nicholas M Matsumoto et al.
Multiply responsive protein nanoparticles are interesting for a variety of applications. Herein, we describe the synthesis of a vault nanoparticle that responds to both temperature and pH. Specifically, poly(N-isopropylacrylamide-co-acrylic...
Accessing photo-based morphological control in phase-separated, cross-linked networks through delayed gelation [0.03%]
通过延迟凝胶化在相分离的交联网络中实现基于光子的形态控制
Caroline R Szczepanski,Jeffrey W Stansbury
Caroline R Szczepanski
This work presents an approach to extend the period for phase separation, independent of temperature, in ambient phase-separating photopolymerizations based on the copolymerization of structurally similar mono- and di-vinyl monomers. Copoly...
Degradable PEGylated Protein Conjugates Utilizing RAFT Polymerization [0.03%]
利用RAFT聚合的可降解的聚乙二醇蛋白共轭体
Caitlin G Decker,Heather D Maynard
Caitlin G Decker
Poly(ethylene glycol) (PEG)-protein therapeutics exhibit enhanced pharmacokinetics, but have drawbacks including decreased protein activities and polymer accumulation in the body. Therefore a major aim for second-generation polymer therapeu...