Polyacrylonitrile nanofibrous mat from electrospinning: Born with potential anti-fungal functionality [0.03%]
通过静电纺丝得到的聚丙烯腈纳米纤维毡：与生俱来的抗真菌功能
Nafisa Sirelkhatim,Arifa Parveen,Dennis LaJeunesse et al.
Nafisa Sirelkhatim et al.
Electrospun nanofibers have been found in many applications such as air/water filtration, performance apparel, drug delivery, and scaffold for tissue engineering and started to be integrated in commercial products, which leads to their expo...
Sulfonated polystyrenes: pH and Mg2+-insensitive amphiphilic copolymers for detergent-free membrane protein isolation [0.03%]
用于无表面活性剂膜蛋白提取的两亲性共聚物——磺化茋类聚合物：耐pH和Mg2+离子变化
Miroslav Janata,Sachin Gupta,Eva Čadová et al.
Miroslav Janata et al.
Amphiphilic polymers are increasingly applied in the detergent-free isolation and functional studies of membrane proteins. However, the carboxylate group present in the structure of many popular variants, such as styrene-maleic acid (SMA) c...
Polymer modification of SARS-CoV-2 spike protein impacts its ability to bind key receptor [0.03%]
聚集体对SARS-CoV-2刺突蛋白结合关键受体能力的影响
Monica Sharfin Rahman,Nethmi De Alwis Watuthanthrige,Bhagya M Chandrarathne et al.
Monica Sharfin Rahman et al.
The global spread of SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) has caused the loss of many human lives and severe economic losses. SARS-CoV-2 mediates its infection in humans via the spike glycoprotein. The receptor bindi...
Molecular dynamics simulations of quinine encapsulation into biodegradable nanoparticles: A possible new strategy against Sars-CoV-2 [0.03%]
分子动力学模拟显示奎宁可以封装到可生物降解的纳米颗粒中：对抗SARS-CoV-2的新可能策略
Pierluigi Stipa,Stefania Marano,Roberta Galeazzi et al.
Pierluigi Stipa et al.
A new coronavirus disease, SARS-CoV-2, has spread into a global pandemic in December 2019. Since no specific therapeutic drugs for treating COVID-19 have been approved by FDA, recent studies suggest that the known antimalarial quinine and i...
Ice recrystallisation inhibiting polymers prevent irreversible protein aggregation during solvent-free cryopreservation as additives and as covalent polymer-protein conjugates [0.03%]
冰再结晶抑制聚合物可防止干燥状态下的蛋白质冷冻保存过程中不可逆的蛋白质聚集作为添加剂和共价聚合物蛋白质缀合物的情况下均有效
Alice E R Fayter,Muhammad Hasan,Thomas R Congdon et al.
Alice E R Fayter et al.
Protein storage and transport is essential to deliver therapies (biologics), enzymes for biotechnological applications, and underpins fundamental structural and molecular biology. To enable proteins to be stored and transported it is often ...
Tuning small molecule release from polymer micelles: Varying H2S release through cross linking in the micelle core [0.03%]
通过交联调节聚合物胶束中释放的小分子：通过改变胶束核心的交联程度来改变H2S的释放量
Ryan J Carrazzone,Jeffrey C Foster,Zhao Li et al.
Ryan J Carrazzone et al.
Polymer micelles, used extensively as vehicles in the delivery of active pharmaceutical ingredients, represent a versatile polymer architecture in drug delivery systems. We hypothesized that degree of crosslinking in the hydrophobic core of...
Diederik W R Balkenende,Sally M Winkler,Phillip B Messersmith
Diederik W R Balkenende
Medical adhesives that are strong, easy to apply and biocompatible are promising alternatives to sutures and staples in a large variety of surgical and clinical procedures. Despite progress in the development and regulatory approval of adhe...
Influence of the organic matrix composition on the polymerization behavior and bulk properties of resin composites containing thiourethane-functionalized fillers [0.03%]
含硫脲官能化填料的树脂复合材料中有机基质组成对聚合行为和整体性能的影响
Ana Paula Fugolin,Ana Rosa Costa,Emilie Kono et al.
Ana Paula Fugolin et al.
Objectives: The incorporation of thiourethane-based oligomeric additives into resin composite formulations leads to improvement in mechanical properties and reduction in polymerization stress, but may increase viscosity. ...
Electrosprayed poly(lactic-co-glycolic acid) particles as a promising drug delivery system for the novel JNK inhibitor IQ-1 [0.03%]
新型JNK抑制剂IQ-1的电喷雾PLGA微球递药系统的研究
Elina Kibler,Anastasia Lavrinenko,Ilya Kolesnik et al.
Elina Kibler et al.
Mitogen-activated protein kinases (MAPKs), including c-Jun N-terminal kinase (JNK), play important role in the regulation of pro-inflammatory cytokine secretion and signaling cascades. Therefore, JNKs are key targets for the treatment of cy...
The application of self-assembled nanostructures in peptide-based subunit vaccine development [0.03%]
基于肽的亚单位疫苗开发中自组装纳米结构的应用
Guangzu Zhao,Saranya Chandrudu,Mariusz Skwarczynski et al.
Guangzu Zhao et al.
Peptide based-vaccines are becoming one of the most widely investigated prophylactic and therapeutic health care interventions against a variety of diseases, including cancer. However, the lack of a safe and highly efficient adjuvant (immun...