The chemokine network. II. On how polymorphisms and alternative splicing increase the number of molecular species and configure intricate patterns of disease susceptibility [0.03%]
趋化因子网络。II. 多态性和选择性剪接如何增加分子种类的数目并形成复杂的疾病易感模式
R Colobran,R Pujol-Borrell,M P Armengol et al.
R Colobran et al.
In this second review on chemokines, we focus on the polymorphisms and alternative splicings and on their consequences in disease. Because chemokines are key mediators in the pathogenesis of inflammatory, autoimmune, vascular and neoplastic...
Overexpression of the autoantigen IA-2 puts beta cells into a pre-apoptotic state: autoantigen-induced, but non-autoimmune-mediated, tissue destruction [0.03%]
自身抗原IA-2过表达使β细胞进入凋亡的前期状态：由自身抗原诱导而非自身免疫介导的组织破坏
S-I Harashima,C Harashima,T Nishimura et al.
S-I Harashima et al.
IA-2 is a major autoantigen in type 1 diabetes and autoantibodies to it have become important diagnostic and predictive markers. IA-2 also is an intrinsic transmembrane component of dense core secretory vesicles and knock-out studies showed...
Dynamic changes in CD4+ CD25+(high) T cell apoptosis after the diagnosis of type 1 diabetes [0.03%]
新诊断1型糖尿病后CD4+CD25+(high)T细胞凋亡的动态变化
S Glisic-Milosavljevic,T Wang,M Koppen et al.
S Glisic-Milosavljevic et al.
Because type 1 diabetes (T1D) is a chronic, autoimmune, T cell-mediated disease, interventions affecting T cells are expected to modulate the immune cascade and lead to disease remission. We propose that increased CD4(+) CD25(+high) T cell ...
Reduced apoptosis and increased inflammatory cytokines in granulomas caused by tuberculous compared to non-tuberculous mycobacteria: role of MPT64 antigen in apoptosis and immune response [0.03%]
结核分枝杆菌诱发的肉芽肿凋亡减少及细胞因子表达异常：MPT64抗原调控作用研究
T Mustafa,H G Wiker,O Mørkve et al.
T Mustafa et al.
Inhibition of apoptosis of infected macrophages by pathogenic mycobacteria is suggested to be an important virulence mechanism, but little is known about the mycobacterial proteins involved in the inhibition of apoptosis. In this study we i...
Suppression of lipopolysaccharide- and tumour necrosis factor-alpha-induced interleukin (IL)-8 expression by glucocorticoids involves changes in IL-8 promoter acetylation [0.03%]
糖皮质激素通过改变细胞因子启动子的乙酰化状态抑制脂多糖和肿瘤坏死因子α诱导的细胞间白介素-8表达
L G Tsaprouni,K Ito,I M Adcock et al.
L G Tsaprouni et al.
There is accumulating evidence that the transrepressional effect of glucocorticoids in down-regulating proinflammatory gene expression might be regulated by an action on histone acetylation. To investigate this, we studied the effect of two...
Translational mini-review series on immunodeficiency: molecular defects in common variable immunodeficiency [0.03%]
免疫缺陷的转化小型综述系列：常见多变免疫缺陷的分子缺陷
C Bacchelli,S Buckridge,A J Thrasher et al.
C Bacchelli et al.
Common variable immunodeficiency (CVID) is a primary immunodeficiency that typically affects adults and is characterized by abnormalities of quantative and qualitative humoral function that are heterogeneous in their immunological profile a...
Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4 [0.03%]
伊曲康唑通过干扰白三烯B4的产生而抑制血小板活化因子刺激的人中性粒细胞内的钙流入
H C Steel,G R Tintinger,A J Theron et al.
H C Steel et al.
The primary objective of this study was to probe the involvement of leukotriene B(4) (LTB(4)) in itraconazole (0.1-5 microM)-mediated inhibition of Ca(2+) uptake by chemoattractant-activated human neutrophils. Following exposure of the cell...
The clearance kinetics of autologous RhD-positive erythrocytes coated ex vivo with novel recombinant and monoclonal anti-D antibodies [0.03%]
体外涂有新型重组和单克隆抗D抗体的自身RhD阳性红细胞的清除动力学
G E Chapman,J R Ballinger,M J Norton et al.
G E Chapman et al.
Anti-D is given routinely to pregnant RhD-negative women to prevent haemolytic disease of the fetus and newborn. To overcome the potential drawbacks associated with plasma-derived products, monoclonal and recombinant forms of anti-D have be...
Randomized Controlled Trial
Clinical and experimental immunology. 2007 Oct;150(1):30-41. DOI:10.1111/j.1365-2249.2007.03458.x 2007
A murine model of appendicitis and the impact of inflammation on appendiceal lymphocyte constituents [0.03%]
阑尾炎的小鼠模型及炎症对阑尾淋巴细胞成分的影响
W S Watson Ng,T Hampartzoumian,A R Lloyd et al.
W S Watson Ng et al.
Data indicate that appendicectomy for intra-abdominal inflammation protects against inflammatory bowel disease (IBD). This suggests an important role for the appendix in mucosal immunity. There is no established model of appendicitis. We th...
Antibodies directed against ribosomal P proteins cross-react with phospholipids [0.03%]
抗核糖体P蛋白的抗体与磷脂发生交叉反应
L Caponi,C Anzilotti,G Longombardo et al.
L Caponi et al.
Anti-ribosomal P protein (anti-P) antibodies are marker antibodies in systemic lupus erythematosus (SLE). Their association with psychiatric or neurological manifestations has been proposed, but remains controversial. Anti-phospholipid anti...