Lenar I Musin,Andrei V Bogdanov,Vladimir F Mironov
Lenar I Musin
In this review we generalize and analyze information about reactions between isatin and three-, four-, and five-coordinate phosphorus compounds, published between 1966 and 2014. ...
Structural Analogs of Umifenovir. 1. Synthesis and Biological Activity of Ethyl 5-Hydroxy-1-Methyl-2-(Trans-2-Phenylcyclopropyl)-1 H-Indole-3-Carboxylate [0.03%]
联合循环的类乌米芬病毒化合物。1.5-乙基-1-甲基-2-(反式-2-苯基环丙基)-1H-吲哚-3-羧酸盐的合成与生物活性研究
J Balzarini,E A Ruchko,E K Zakharova et al.
J Balzarini et al.
Ethyl 5-hydroxy-1-methyl-2-(trans-2-phenylcyclopropyl)-1H-indole-3-carboxylate is the first prototype of conformationally restricted analogs of umifenovir. It has been prepared using a one-pot method and has undergone an antiviral study. ...
4-Hydroxy-2-quinolones 139. Synthesis, structure, and antiviral activity of N-R-amides of 2-hydroxy-4-oxo-4H-pyrido[1,2- a]pyrimidine-3-carboxylic acids [0.03%]
2-羟基-4-氧代-4H-吡啶并[1，2-a]嘧啶-3-羧酸的N-R酰胺类化合物的合成、结构和抗病毒活性研究（139）
I V Ukrainets,N L Bereznyakova,I A Turaibei
I V Ukrainets
Dialkylaminoalkylamides of 2-hydroxy-4-oxo-4H-pyrido[1,2-a]pyrimidine-3-carboxylic acids have been obtained as potential antiviral agents. The special features of the spatial structure of one example of the synthesized compounds have been s...
Acyclic analogs of nucleosides. Synthesis and in vitro antiviral activity of hydroxyalkyl-2-(trifluoromethylthiomethyl) benzimidazoles [0.03%]
核苷的环状类似物的合成及体外抗病毒活性研究：具有羟基烷基-2-(三氟甲基硫代甲基)苯并咪唑类化合物的研究
A É Yavorskii,A V Turov,I V Gogoman et al.
A É Yavorskii et al.
In a search for novel antiviral compounds of the 'doubly modified' nucleoside type, we have prepared 1-(4-hydroxy-2-oxabutyl)-, 1-(4-hydroxy-3-hydroxymethyl-2-oxabutyl)-, 1-(4-hydroxy-1-hydroxymethy1-2-oxabutyl)-, 1-(4-hydroxy-1-methyl-2-ox...
Acyclic analogs of nucleosides. Synthesis of hydroxyalkyl derivatives of 2-trifluoromethyl- and 2-trifluoromethylthiobenzimidazole [0.03%]
核苷的非环状类似物。2-三氟甲基和2-三氟甲硫基苯并咪唑羟烷基衍生物的合成
A É Yavorskii,A V Stetsenko,I V Gogoman et al.
A É Yavorskii et al.
1-(2,3-Dihydroxypropyl)-, 1-(4-hydroxy-2-oxabutyl)-, 1-(3-hydroxymethyl-4-hydroxy-2-oxabutyl)-, 1-(1,5-dihydroxy-3-oxa-2-pentyl)-, 1-(5-hydroxy-3-oxa-2-pentyl)-, and 1-(4,5-dihydroxy-2-oxapentyl)-2-trifluoromethyl- and -2-trifluoromethylthi...
I V Magedov,A Kornienko
I V Magedov
Multicomponent reactions are emerging as a powerful tool in alkaloid-based drug discovery. This Highlight describes several recent (all published in 2011) examples of the employment of multicomponent reactions for the synthesis of biologica...
ORGANOCOPPER-MEDIATED TWO-COMPONENT SN2'-SUBSTITUTION CASCADE TOWARDS N-FUSED HETEROCYCLES [0.03%]
有机铜介导的SN2'-取代级联反应构建N-稠环杂环化合物
D Chernyak,V Gevorgyan
D Chernyak
Organocuprates efficiently undergo reaction with heterocyclic propargyl mesylates at low temperature to produce N-fused heterocycles. The copper reagent plays a "double duty" in this cascade transformation, which proceeds through an SN2'-su...
S J Hasty,A V Demchenko
S J Hasty
This review discusses the synthesis and application of glycosyl thioimidates in chemical glycosylation and oligosaccharide assembly. Although glycosyl thioimidates include a broad range of compounds, the discussion herein centers on S-benzo...