Methods of Synthesis and Antiviral Activity of New 4-Alkyl-3-Nitro-1,4-Dihydroazolo[5,1- c][1,2,4]Triazin-4-ols [0.03%]
新的4-烷基-3-硝基-1,4-二氢氮杂环唑[5,1-c][1,2,4]三嗪-4-醇的合成方法及抗病毒活性研究
Roman A Drokin,Dmitrii V Tiufiakov,Egor K Voinkov et al.
Roman A Drokin et al.
An azo coupling reaction of α-nitro ketones with 5-diazoazoles was used to obtain 4-alkyl-3-nitro-1,4-dihydroazolo[5,1-с][1,2,4]triazines, which were characterized with respect to their antiviral activity against influenza and Coxsackie B...
Antiviral drug Triazavirin, selectively labeled with 2H, 13C, and 15N stable isotopes. Synthesis and properties [0.03%]
用于抗病毒药物Triazavirin的选择性氘、碳-13和氮-15稳定同位素标记及其合成与性质研究
Tatyana S Shestakova,Sergey L Deev,Igor А Khalymbadzha et al.
Tatyana S Shestakova et al.
Isotope-labeled antiviral drug Triazavirin containing 2H, 13C, and 15N atoms in its structure has been synthesized. 13C2H3I and KS13CN served as donors of 13C isotopes. The use of 13С-MeI containing 2H atoms made it possible to additionall...
Synthetic strategies for pyrrolo[2,1- f][1,2,4]triazine: the parent moiety of antiviral drug remdesivir [0.03%]
合成异并三嗪类抗病毒药物瑞德西韦母核化合物的策略研究
Gaurav S Rai,Jayesh J Maru
Gaurav S Rai
This review summarizes diverse synthetic protocols for the preparation of pyrrolo[2,1-f][1,2,4]triazine derivatives, covering literature sources from the past two decades. For effective representation, the synthetic methods toward the title...
Application of BF3·Et2O in the synthesis of cyclic organic peroxides (microreview) [0.03%]
三氟化硼乙醚合物在有机过氧化物合成中的应用(微型综述)
Peter S Radulov,Ivan A Yaremenko
Peter S Radulov
A summary of recent applications of Lewis acid BF3·Et2O as a catalyst in the synthesis of cyclic organic peroxides is presented. © Springer Science+Bus...
Diazapyrenes: interaction with nucleic acids and biological activity [0.03%]
diazapyrene：与核酸的相互作用及其生物活性
Andrey M Zhirov,Dmitry A Kovalev,Diana V Ulshina et al.
Andrey M Zhirov et al.
The review summarizes data on the practical aspects of the interaction of nucleic acids with diazapyrene derivatives. The information on biological activity is given and the probable mechanisms underlying the action of diazapyrenes are anal...
Heterocyclic Inhibitors of Viroporins in the Design of Antiviral Compounds [0.03%]
杂环抑制剂作为抗病毒化合物在设计中的作用于病毒蛋白通透口
Vadim A Shiryaev,Yuri N Klimochkin
Vadim A Shiryaev
Ion channels of viruses (viroporins) represent a common type of protein targets for drugs. The relative simplicity of channel architecture allows convenient computational modeling and enables virtual search for new inhibitors. In this revie...
Yulia A Titova,Olga V Fedorova
Yulia A Titova
The routes of synthesis are considered, as well as the modifications of the promising modern antiviral drug favipiravir. Literature data from the last 10 years are reported. ...
Mikhail V Chudinov
Mikhail V Chudinov
This review article is devoted to the so-called fleximer nucleoside analogs, containing two or more planar moieties in the heterocyclic base, connected by a bond that permits rotation. Such analogs have been proposed as molecular probes for...
Privileged heterocycles: bioactivity and synthesis of 1,9-diazaspiro[5.5]undecane-containing compounds [0.03%]
含1,9-二氮杂螺[5.5]十一烷类privileged异环化合物的生物活性及合成研究
Daniel Blanco-Ania,Rik Heus,Floris P J T Rutjes
Daniel Blanco-Ania
This review discusses the biological activity and synthesis of 1,9-diazaspiro[5.5]undecanes, including those ring-fused with arenes and heteroarenes and/or containing a carbonyl group at position 2. These compounds could be used for the tre...
Preparation and biological properties of 2-thio-containing pyrimidines and their condensed analogs [0.03%]
含硫嘧啶及其缩合类似物的制备和生物活性研究
Oleksii Yu Voskoboynik,Oleksandra S Kolomoets,Galyna G Berest et al.
Oleksii Yu Voskoboynik et al.
The known methods for synthesis of thioxopyrimidines and their condensed analogs with exocyclic sulfur atom are summarized and discussed. The most popular approaches are based on [3+3], [4+2], [5+1] cyclization processes or domino reactions...